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Preparation method of nanocellulose/polylactic acid in situ composite porous scaffold

A technology of nanocellulose and in-situ compounding, applied in medical science, prostheses, etc., can solve problems such as easy agglomeration, limitation of mechanical properties of composite materials, lack of chemical bonds, etc., to achieve improved compatibility, improved mechanical properties, The effect of improving dispersion

Inactive Publication Date: 2018-06-29
CENTRAL SOUTH UNIVERSITY OF FORESTRY AND TECHNOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, pure polylactic acid materials still have some shortcomings: polylactic acid is a polyester polymer, and the presence of ester groups makes polylactic acid have strong hydrophobicity and low adsorption capacity to tissue cells, which is not conducive to cell adsorption and growth; Polylactic acid has only an initial moderate strength and cannot be used as a bone tissue fixation material for bearing parts
However, nanocellulose is a hydrophilic material, polylactic acid is a hydrophobic material, and the specific surface area of ​​nanocellulose is large, so it is easy to agglomerate. The dispersion of nanocellulose in polylactic acid matrix is ​​not good, and the mechanical properties of the prepared composite material The improvement is limited, and the advantages of the mechanical properties of nanocellulose reinforced composites cannot be fully utilized
Existing studies have modified nanocellulose or polylactic acid to reduce the polarity of nanocellulose or increase the hydrophilicity of polylactic acid to improve the interfacial compatibility between the two, but there is a lack of chemical bonds between the two. Interface adhesion is not ideal

Method used

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  • Preparation method of nanocellulose/polylactic acid in situ composite porous scaffold
  • Preparation method of nanocellulose/polylactic acid in situ composite porous scaffold

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Take 100g mass concentration of 90% lactic acid aqueous solution and 22.5g mass concentration of 0.8% nanocellulose aqueous suspension in a 250ml three-necked flask, ultrasonically disperse for 30min under the condition of stirring speed of 150r / min, and then heat up to 90 ℃, dehydrated at vacuum degree -0.085MPa for 3 hours, then raised the temperature to 130℃, raised the vacuum degree to -0.095MPa, dehydrated for 3 hours, added stannous chloride with 0.5% lactic acid mass, and added For p-toluenesulfonic acid, gradually increase the temperature to 180°C within 1 hour, keep the vacuum at -0.095MPa, react for 10 hours, and end the reaction. Lactic acid in-situ composite prepolymer; place the prepolymer in a conical flask, evacuate to -0.095MPa, heat up to 105°C for 2h, then heat up to 145°C for solid phase polymerization for 20h, and use Dichloromethane was dissolved, anhydrous ethanol was precipitated, and then vacuum-dried for 24 hours to obtain the nanocellulose / poly...

Embodiment 2

[0020] Take 100g mass concentration of 90% lactic acid aqueous solution and 45.0g mass concentration of 0.8% nanocellulose aqueous suspension in a 250ml three-necked flask, and ultrasonically disperse for 30min under the condition of stirring speed of 150r / min, and then heat up to 90 ℃, dehydrated at vacuum degree -0.085MPa for 3 hours, then raised the temperature to 130℃, raised the vacuum degree to -0.095MPa, dehydrated for 3 hours, added stannous chloride with 0.5% lactic acid mass, and added For p-toluenesulfonic acid, gradually increase the temperature to 180°C within 1 hour, keep the vacuum at -0.095MPa, react for 10 hours, and end the reaction. Lactic acid in-situ composite prepolymer; place the prepolymer in a conical flask, evacuate to -0.095MPa, heat up to 105°C for 2h, then heat up to 145°C for solid phase polymerization for 20h, and use Dichloromethane was dissolved, anhydrous ethanol was precipitated, and then vacuum-dried for 24 hours to obtain the nanocellulose / ...

Embodiment 3

[0023] Take 100g mass concentration of 90% lactic acid aqueous solution and 67.5g mass concentration of 0.8% nanocellulose aqueous suspension in a 250ml three-necked flask, and ultrasonically disperse for 30min under the condition that the stirring speed is 150r / min, and then heat up to 90 ℃, dehydrated at vacuum degree -0.085MPa for 3 hours, then raised the temperature to 130℃, raised the vacuum degree to -0.095MPa, dehydrated for 3 hours, added stannous chloride with 0.5% lactic acid mass, and added For p-toluenesulfonic acid, gradually increase the temperature to 180°C within 1 hour, keep the vacuum at -0.095MPa, react for 10 hours, and end the reaction. Lactic acid in-situ composite prepolymer; place the prepolymer in a conical flask, evacuate to -0.095MPa, heat up to 105°C for 2h, then heat up to 145°C for solid phase polymerization for 20h, and use Dichloromethane was dissolved, anhydrous ethanol was precipitated, and then vacuum-dried for 24 hours to obtain the nanocell...

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Abstract

The invention belongs to the field of tissue engineering scaffold preparation, and particularly relates to a preparation method of a nanocellulose / polylactic acid in-situ composite porous scaffold. The method comprises the following steps that a nanocellulose aqueous suspension and lactic acid are taken as raw materials, and a nanocellulose / polylactic acid in-situ composite polymer is prepared through an in-situ polymerization method; the nanocellulose / polylactic acid in-situ composite polymer is added into dioxane / water mixed solvent, and even dispersion is conducted through an ultrasonic wave; the mixture is poured into a mold, and the nanocellulose / polylactic acid in-situ composite porous scaffold is obtained through freezing, vacuum drying and demolding. The dispersity of nanocellulose in the porous scaffold is good, chemical bond combination exists between the nanocellulose and a polylactic acid matrix, the compatibility of the interfaces of the nanocellulose and the polylactic acid matrix is greatly strengthened, and the mechanical property of the scaffold can be obviously improved.

Description

technical field [0001] The invention belongs to the field of preparation of tissue engineering scaffolds, and in particular relates to a preparation method of nanocellulose / polylactic acid in-situ composite porous scaffolds. Background technique [0002] Polylactic acid is a thermoplastic linear aliphatic polyester with good biocompatibility and biodegradability, moderate strength, and can be used as a cell growth carrier in the field of tissue engineering such as regeneration and repair of bone tissue and cartilage tissue. Material requirements. However, pure polylactic acid materials still have some shortcomings: polylactic acid is a polyester polymer, and the presence of ester groups makes polylactic acid have strong hydrophobicity and low adsorption capacity to tissue cells, which is not conducive to cell adsorption and growth; Polylactic acid has only an initial moderate strength and cannot be used as a bone tissue fixation material for load-bearing parts. [0003] Na...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/56A61L27/18A61L27/20A61L27/50
Inventor 罗卫华袁彩霞袁光明
Owner CENTRAL SOUTH UNIVERSITY OF FORESTRY AND TECHNOLOGY