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Fluorescent probe for zinc ion and cadmium ion detection as well as preparation method and application of fluorescent probe

A fluorescent probe and cadmium ion technology, applied in the field of fluorescent probes, can solve the problems of cadmium central nervous system damage, easy interference with renal function and reproductive function, and difficulty in excretion of cadmium.

Inactive Publication Date: 2016-02-03
DALIAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In addition, cadmium is extremely damaging to the central nervous system of the human body, and cadmium is difficult to excrete, which can easily interfere with kidney function and reproductive function.

Method used

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  • Fluorescent probe for zinc ion and cadmium ion detection as well as preparation method and application of fluorescent probe
  • Fluorescent probe for zinc ion and cadmium ion detection as well as preparation method and application of fluorescent probe
  • Fluorescent probe for zinc ion and cadmium ion detection as well as preparation method and application of fluorescent probe

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Experimental program
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Effect test

Embodiment 1

[0024] in N 2 Under the protection of N-ethylcarbazole-3-carbaldehyde (4.13mmol) and 2-acetylpyridine (8.26mmol) were dissolved in 100mL ethanol, then added 331mg sodium hydroxide and 10.5mmol ammonia water, stirred at room temperature for 24 hours; after the reaction is finished, cool to room temperature, spin dry the liquid, add 60mL saturated brine to wash, and then extract with dichloromethane; use dichloromethane and methanol with a volume ratio of 200:1 as the eluent, and use a column The product was separated and collected by chromatography, and spin-dried to obtain the product.

Embodiment 2

[0026] The ultraviolet-visible absorption spectrum test of the probe on zinc ions: dissolve the probe in acetonitrile-HEPES buffer solution to prepare a solution with a concentration of 29.5 μmol / L, then add 0-1.0 eq of zinc ion aqueous solution dropwise, and wait for equilibrium Finally, test the UV absorption spectrum at room temperature, the test results are shown in figure 1 .

Embodiment 3

[0028] Fluorescence emission spectrum test of the probe to zinc ions: Dissolve the probe in the acetonitrile-HEPES buffer solution to form a solution with a concentration of 29.5 μmol / L, then add 0-1.0 eq of zinc ion aqueous solution dropwise, and after equilibrium, Test the fluorescence emission spectrum at room temperature, see the test results figure 2 .

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Abstract

The invention belongs to a fluorescent chemical sensing technology, and provides a fluorescent probe for zinc ion and cadmium ion detection as well as a preparation method and application of the fluorescent probe. The probe has a recognition function on zinc ions and cadmium ions; the probe, zinc ions and cadmium ions take a reaction in acetonitrile-HEPES (hydroxyethylpiperazine ethane sulfonic acid) buffer liquid (pH=7.4, v / v=1:1), so that fluorescence of the probe is quenched; the lowest detection concentration on the zinc ions is 0.39 mumol / L; the lowest detection concentration on the cadmium ions is 0.34 mumol / L. Therefore test paper containing the probe can be used for naked-eye qualitative verification on the zinc ions and the cadmium ions.

Description

technical field [0001] The invention relates to a fluorescent probe with high selectivity recognition and a preparation method thereof, in particular to a kind of fluorescent probe with terpyridyl as a recognition acceptor, which can selectively recognize zinc ions and cadmium ions. Background technique [0002] Metal ions play an important role in the environment and biological processes, but among many metal ions, zinc ions, as the second most essential element in the human body, play a crucial role. An appropriate amount of zinc ions in the human body can help wounds heal, promote the growth of babies, and maintain the normal functions of taste and smell. When zinc is deficient, various diseases can be caused, such as: Alzheimer's disease, epilepsy, prostate cancer and Parkinson's syndrome, arteriosclerosis, etc. [0003] Cadmium ions are widely used in agronomy and industry. However, cadmium is a highly toxic heavy metal element for the human body, mainly derived from ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/64
Inventor 晁多斌倪士昙牟文生彭延硕孙晓怡肖梦杰
Owner DALIAN UNIV OF TECH
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