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Method for preparing annular platinum nanoparticles with lanreotide acetate serving as template

A technology of lanreotide acetate and platinum nanotechnology, which is applied in the direction of nanotechnology, can solve the problems of complex preparation process, severe reaction conditions, and high equipment requirements, and achieve the effect of simple molecular structure, uniform particle size, and good dispersion

Inactive Publication Date: 2016-02-10
YANSHAN UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] At present, nanorings are mainly prepared by methods such as photolithography, liquid phase precipitation, and colloidal ball template method, but these methods have complex preparation processes, high costs, severe reaction conditions, high equipment requirements, and environmental pollution. shortcoming

Method used

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  • Method for preparing annular platinum nanoparticles with lanreotide acetate serving as template
  • Method for preparing annular platinum nanoparticles with lanreotide acetate serving as template
  • Method for preparing annular platinum nanoparticles with lanreotide acetate serving as template

Examples

Experimental program
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Effect test

Embodiment 1

[0021] Take 0.25 mg of lanreotide acetate (manufactured by Wuxi Maimertop Biotechnology Co., Ltd.), and dissolve it in 1 mL of hydrochloric acid solution at pH 4.0 to prepare a lanreotide acetate solution. Place the lanreotide acetate solution on a metal In the bath for 20 minutes; mix 200 μL of lanreotide acetate solution after the metal bath with 150 μL of 1.0 mM platinum tetrachloride solution (Tianjin Chemical Reagent Factory) and put it into a constant temperature oscillator in a water bath. The control speed is 100 rpm and the temperature is 30 °C Incubate under the conditions for 18 hours; finally add 40 μL of 7.5 mM sodium borohydride (produced by Beijing Zhongsheng Huateng Technology Co., Ltd.) dropwise for reduction, the dropping speed is 1-2 drops / min, 20 μL / drop, the reaction temperature is 30 °C, and the reaction After 10 minutes, it slowly changed from light yellow to gray black, and the lanreotide acetate-cyclic platinum nanoparticles were obtained.

[0022] The...

Embodiment 2

[0024] Take 0.5 mg of lanreotide acetate and dissolve it in 1 mL of hydrochloric acid solution at pH 4.5 to prepare a lanreotide acetate solution. Put the lanreotide acetate solution in a metal bath at 55°C for 25 minutes; The reetide solution was mixed with 150 μL of 2.0 mM platinum tetrachloride solution, and then placed in a constant temperature oscillator in a water bath, and incubated at a temperature of 30°C for 21 h at a controlled speed of 150 rpm; finally, 80 μL of 7.5 mM sodium borohydride was added dropwise for reduction. The speed is 1-2 drops / minute, 20 μL / drop, the reaction temperature is 32°C, and the reaction is carried out for 10 minutes, so that it slowly changes from light yellow to gray black, and lanreotide acetate-cyclic platinum nanoparticles are obtained.

[0025] The morphology of ring-shaped platinum nanoparticles was characterized by transmission electron microscopy, as shown in figure 2 As shown, the ring width of the ring-shaped platinum nanoparti...

Embodiment 3

[0027] Take 1.0 mg of lanreotide acetate and dissolve it in 1 mL of hydrochloric acid solution at pH 5.0 to prepare a lanreotide acetate solution. Place the lanreotide acetate solution in a metal bath at 60°C for 30 minutes; take 200 μL of lanreotide acetate The reetide solution was mixed with 150 μL of 4.0 mM platinum tetrachloride solution, and then placed in a constant temperature oscillator in a water bath, and incubated at a temperature of 30°C for 24 hours at a controlled speed of 200 rpm; finally, 120 μL of 7.5 mM sodium borohydride was added dropwise for reduction. The speed is 1-2 drops / minute, 20 μL / drop, the reaction temperature is 35°C, and the reaction is carried out for 10 minutes, so that it slowly changes from light yellow to gray black, and lanreotide acetate-cyclic platinum nanoparticles are obtained.

[0028] The morphology of ring-shaped platinum nanoparticles was characterized by transmission electron microscopy, as shown in image 3 As shown, the ring wid...

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Abstract

A method for preparing annular platinum nanoparticles with lanreotide acetate serving as a template mainly includes the steps that a lanreotide acetate solution is prepared according to the ratio that 0.25-1.0 mg of lanreotide acetate is added into each milliliter of hydrochloric acid solution with the pH value being 4-5, and then the lanreotide acetate solution is placed in a metal bath with the temperature being 50-60 DEG C for 20-30 min; a platinum tetrachloride solution is added into the lanreotide acetate solution, the molar ratio of the lanreotide acetate solution to the platinum tetrachloride solution is 1:3-4, the mixed solution is placed in a constant temperature water bath oscillator to be rotated by 100-200 rpm and incubated for 18-24 h at the temperature of 30 DEG C; the incubated solution is added with a reducing agent, namely sodium borohydride, the molar ratio of the reducing agent to the platinum tetrachloride solution being 1:1-2, the reaction temperature is about 30-35 DEG C, the reaction time is 10 min, and then the lanreotide acetate-annular platinum nanoparticles with the ring width being 20-30 nm and the inner diameter being 40-100 nm and having good dispersibility are obtained. The method has the advantages that cost is low, the process is simple, the reaction conditions are moderate, and environment friendliness and morphology controllability are achieved.

Description

technical field [0001] The invention belongs to the technical field of metal materials, in particular to a preparation method of nanometer materials. Background technique [0002] Platinum nanomaterials have a wide range of applications, such as in fuel cells, biosensors, chemical sensors, automotive catalytic converters, petroleum refining, hydrogen production, and anticancer drugs. Platinum nanorings have been seldom studied in the previous preparation techniques due to the complex preparation conditions and difficulty in controlling the morphology. At present, the research on platinum-based metal anticancer drugs is developing rapidly. Platinum nanorings can be used in many fields such as sensors, drug-loading systems, and catalysis due to their unique structural properties. In addition, due to the special shape characteristics of the nano ring itself, it has the characteristics of high bending resistance, compression resistance and tensile strength, and can be used in t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B22F9/24B82Y40/00
Inventor 高大威薛伟利李彦集高发明王梓尹甜边可新
Owner YANSHAN UNIV
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