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Chitosan gel particle lotion and preparation method thereof

A chitosan gel and chitosan technology are applied in the direction of pharmaceutical formulations, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., which can solve drug dependence, stubborn dirt that cannot be cleaned thoroughly, Interfering with the self-cleaning ability of private parts and other issues, to achieve a high safety effect

Inactive Publication Date: 2016-02-17
WUHAN HUMANWELL MEDICAL SUPPLIES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Existing lotions currently on the market do not contain abrasives, and cannot thoroughly clean stubborn dirt stored in the private parts; in addition, most of these private parts lotions also contain strong bactericidal ingredients, such as Chinese Patent Publication No. CN103463284A, disclosed The date is December 25, 2013, the name of the invention is "a gynecological cleaning solution and its preparation method", the Chinese patent publication number is CN103263525A, the publication date is August 28, 2013, the invention name is "a gynecological cleaning solution The lotion formula disclosed in "and its preparation method" contains high-concentration Chinese herbal medicine extract. The Chinese patent publication number is CN103446177A, and the publication date is December 18, 2013. Contain chlorhexidine medicine in the washing formula disclosed in "preparation method"
Long-term use of these high-efficiency bactericidal ingredients and other drugs will not only easily make the human body dependent on the drugs, destroy the balance of natural flora in the private parts, interfere with the self-cleaning ability of the private parts, but also cause certain irritation to the soft skin of the private parts, which has certain side effect

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0060] Described preparation method carries out as follows:

[0061] a Preparation of chitosan gel particles

[0062] Disperse chitosan powder with a particle size of 1-5um in isopropanol at a mass volume ratio of 1:20, and then add 2,3 -Epoxypropyltrimethylammonium chloride, moved into a shaker, and oscillated evenly at room temperature to obtain a solid-liquid mixture of chitosan powder. In the chitosan powder-solid-liquid mixture, the mass volume ratio of chitosan was 1:2 Add a sodium hydroxide solution with a concentration of 20wt%, oscillate evenly at room temperature to obtain a chitosan powder reaction mixture, react the chitosan powder reaction mixture in a constant temperature water bath at 90°C for 10 hours, and separate the reacted chitosan The sugar powder was washed twice with 80v% ethanol aqueous solution and absolute ethanol successively, and the chitosan powder after washing was dried at 40°C to obtain chitosan gel particles with a substitution degree of 90%; ...

Embodiment 1

[0080] a Preparation of chitosan gel particles

[0081] Weigh 50g of chitosan and disperse it in 1000mL of isopropanol, add 235g of 2,3-epoxypropyltrimethylammonium chloride, move it into a shaker, oscillate evenly at room temperature, then add 100g of NaOH with a concentration of 20wt% solution, shake evenly at room temperature, react in a constant temperature water bath at 90°C for 10 hours, separate the reacted chitosan powder, and wash twice with 80v% ethanol aqueous solution and absolute ethanol successively, and the chitosan after washing The powder was dried at 40°C to obtain chitosan gel particles with a substitution degree of 90%.

[0082] Preparation of b chitosan gel particle lotion

[0083] The chitosan gel particles obtained through step a and other materials are proportioned as follows:

[0084] raw material name Recipe (g) Chitosan Gel Microparticles 10.0 Fatty alcohol polyoxyethylene ether ammonium sulfate 25.0 Disodium Cocoamphodi...

Embodiment 2

[0087] a Preparation of chitosan gel particles

[0088] Weigh 50g of chitosan and disperse it in 1000mL of isopropanol, add 235g of 2,3-epoxypropyltrimethylammonium chloride, move it into a shaker, oscillate evenly at room temperature, then add 100g of NaOH with a concentration of 20wt% solution, shake evenly at room temperature, react in a constant temperature water bath at 90°C for 10 hours, separate the reacted chitosan powder, and wash twice with 80v% ethanol aqueous solution and absolute ethanol successively, and the chitosan after washing The powder was dried at 40°C to obtain chitosan gel particles with a substitution degree of 90%.

[0089] Preparation of b chitosan gel particle lotion

[0090] The chitosan gel particles obtained through step a and other materials are proportioned as follows:

[0091] raw material name Recipe (g) Chitosan Gel Microparticles 2.5 Cocoyl Hydroxysultaine 40.0 Sodium myristoyl sarcosinate 30.0 Sodium Laur...

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Abstract

The invention belongs to the field of daily chemicals and relates to a chitosan gel particle lotion and a preparation method thereof. The chitosan gel particle lotion is prepared by matching synthetic chitosan gel particles with a surfactant extremely mild in performance, adding essences of animals and plants, and stirring. Synergistic decontamination functions of the chitosan gel particles and the surfactant are given into full play to achieve a thorough cleaning efficacy, avoidance of skin irritation and allergy, high safety and availability for long-term use are realized, and the problem of skin irritation caused by long-term use of traditional lotions incomplete in determination is completely solved. Moreover, the preparation method of the chitosan gel particle lotion is simple and suitable for industrial production.

Description

technical field [0001] The invention relates to a lotion and a preparation method thereof, in particular to a chitosan gel microparticle lotion and a preparation method thereof, belonging to the field of daily chemical industry. Background technique [0002] Gynecological diseases such as vaginitis, cervicitis, and cervical erosion are prone to symptoms such as itching and odor, abnormal leucorrhea, and burning of the lower body. The occurrence of gynecological inflammation is closely related to its own constitution and living habits, and the etiology is complex and diverse. In my country, 70% of married women suffer from various degrees of gynecological diseases, and the prevalence rate shows a clear upward trend. Due to its special physiological structure, men's private parts are very easy to hide dirt, and it is also easy to cause various skin diseases, itching, inflammation and other symptoms. Inflammation of private parts seriously affects people's daily work and life...

Claims

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Application Information

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IPC IPC(8): A61K38/38A61K36/886A61K36/896A61K36/61A61K36/355A61K36/738A61K36/732A61K36/288A61K36/286A61K36/232A61K36/02A61K38/00A61K36/287A61K36/258A61K36/16A61K35/56A61K31/722A61K47/34A61K47/26A61K47/18A61K47/20A61P15/00A61P15/02A61K31/045A61K31/704
Inventor 周应山卢丽丽齐亚凤尹乃达
Owner WUHAN HUMANWELL MEDICAL SUPPLIES
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