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A kind of preparation method of lactic acid bacteria microcapsules for feeding

A technology of lactic acid bacteria microcapsules and lactic acid bacteria, which is applied in the field of preparation of lactic acid bacteria microcapsules for feed, can solve problems such as inability to tolerate high temperature feed, inability to release rapidly, and low activity of lactic acid bacteria, so as to avoid moisture absorption, reduce breakage rate, and improve product quality. quality effect

Active Publication Date: 2019-09-20
云南千村农牧科技集团有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In order to solve the defects of low activity of lactic acid bacteria in the lactic acid bacteria capsules prepared in the prior art, which cannot be released rapidly in the intestinal tract, cannot withstand the high temperature in the feed pelleting process, is easy to absorb moisture and deteriorate during storage, and has high cost defects, the present invention provides A preparation method for feeding lactic acid bacteria microcapsules with high activity, which can safely pass through the gastric juice and quickly disintegrate after entering the intestinal tract

Method used

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  • A kind of preparation method of lactic acid bacteria microcapsules for feeding
  • A kind of preparation method of lactic acid bacteria microcapsules for feeding
  • A kind of preparation method of lactic acid bacteria microcapsules for feeding

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Embodiment 1

[0025] A preparation method for lactic acid bacteria microcapsules for feeding, comprising the following steps:

[0026] A, pullulan polysaccharide modification: first take pullulan polysaccharide and dissolve in dimethyl sulfoxide according to the ratio of 1:20, get pullulan polysaccharide solution, set aside; then 4 parts by weight of cholesterol and 5 parts by weight The succinic anhydride was dissolved in 3 parts of pyridine, and glacial hydrochloric acid was added to obtain a white flocculent precipitate, which was collected after refrigeration and filtration; the white flocculent precipitate was washed with distilled water to pH>5, and placed in ethyl acetate / ethanol Recrystallize, and then dry at 75-85°C to obtain white needle-like succinyl cholesterol; dissolve succinyl cholesterol and 4-dimethylaminopyridine in dimethyl sulfoxide, and activate the reaction for 50 minutes to obtain a reaction solution; add the reaction solution to After reacting in the pullulan solutio...

Embodiment 2

[0034] A preparation method for lactic acid bacteria microcapsules for feeding, comprising the following steps:

[0035] A. Pullulan modification: firstly take pullulan and dissolve it in dimethyl sulfoxide at a ratio of 1:30 to obtain a pullulan solution for subsequent use; then mix 5 parts by weight of cholesterol and 4 parts by weight The succinic anhydride was dissolved in 4 parts of pyridine, and glacial hydrochloric acid was added to obtain a white flocculent precipitate, which was collected after refrigeration and filtration; the white flocculent precipitate was washed with distilled water to pH>5, and placed in ethyl acetate / ethanol Recrystallize, and then dry at 75-85°C to obtain white needle-like succinyl cholesterol; dissolve succinyl cholesterol and 4-dimethylaminopyridine in dimethyl sulfoxide, and activate the reaction for 60 minutes to obtain a reaction solution; add the reaction solution to After reacting in the pullulan solution, it was dropped into absolute e...

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Abstract

The present invention discloses a preparation method of a feed lactic acid bacterium microcapsule. The activity of lactic acid bacteria in the prepared lactic acid bacterium microcapsule in the prior art is low, the lactic acid bacteria cannot be rapidly released in intestinal tract and cannot tolerate the high temperature in the feed pelleting process, the microcapsule is prone to absorb moisture and get deteriorate during the storage process, and the cost is relative high. The feed lactic acid bacterium microcapsule preparation method comprises the following steps: A, modifying pullulan; B, preparing capsule core material; C, preparing wall material; D, preparing capsules; E, coating lactic acid bacterium microcapsule semi-finished products; F, performing shaping and pre-drying; and G, obtaining the lactic acid bacterium microcapsule finished products. The modified water proof pullulan is used as a main component for a coating material, after coating, a water proof layer is formed on the surface of the lactic acid bacterium microcapsule, and is not prone to absorb moisture and get deteriorate during the storage process. Compared to the non-embedded lactic acid bacteria, the obtained lactic acid bacterium microcapsule has an obvious improved acid resistance, bile salt resistance, heat resistance, and storability, and can disintegrate and release lactic acid bacteria rapidly in the intestine tract.

Description

technical field [0001] The invention relates to a production method specially suitable for feeding animals, in particular to a preparation method of lactic acid bacteria microcapsules for feeding. Background technique [0002] Lactic acid bacteria refers to a general term for a class of non-spore-forming, Gram-positive bacteria that can ferment sugars to produce lactic acid. They are the earliest and most widely used probiotics and have been widely used in various animal feeds. Since the probiotic effect of lactic acid bacteria is host-specific, its stress resistance is poor and it is easy to inactivate, which greatly affects its application value. For example, the pH of gastric juice is usually below 2.5. This acidity destroys most of the ingested lactic acid bacteria, and only about one millionth of the lactic acid bacteria can reach the large intestine alive. When lactic acid bacteria are added to the feed for granulation, the usual feed granulation temperature is 80°C, ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/50A23K10/18A23K40/30
Inventor 邓绍贤张以芳周玉照邓绍纲柴俊郑锦玲张云娟杨洁
Owner 云南千村农牧科技集团有限公司