Method for modifying surfaces of gold nanoparticles through ionic liquid

A gold nanoparticle, ionic liquid technology, applied in nanotechnology, metal processing equipment, transportation and packaging, etc., can solve the problems of difficult operation, complicated experimental scheme, and traditional methods take a long time, and achieve the goal of reducing biological toxicity and method. Simple, efficient, safe, and good biocompatibility

Inactive Publication Date: 2016-03-02
CAPITAL NORMAL UNIVERSITY
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0008] An object of the present invention is to solve the problems that the traditional method takes a long time and the experimental scheme is complicated and difficult to operate

Method used

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  • Method for modifying surfaces of gold nanoparticles through ionic liquid
  • Method for modifying surfaces of gold nanoparticles through ionic liquid
  • Method for modifying surfaces of gold nanoparticles through ionic liquid

Examples

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Effect test

no. 1 example

[0071] Firstly, the preparatory step is carried out: GNRs with uniform size and good dispersion are prepared by the classic seed growth method ( Figure 1a ):

[0072] (1) Gold seed preparation: Add 5 mL of 0.5 mM chloroauric acid (HAuCl) to 5 mL of 0.2 M CTAB aqueous solution 4 ) solution, and mix well. Quickly add 0.6 mL of 10 mM ice-cold sodium borohydride (NaBH 4 ) solution, after the addition is complete, mix evenly, put it statically in a water bath at 27°C, and finish the reaction after 2-3 hours, and confirm it by ultraviolet-visible spectroscopy.

[0073] (2) Preparation of GNRs: Add 5 mL of 1 mM HAuCl to 5 mL of 0.2 M CTAB aqueous solution 4 aqueous solution, and then mix well. Add 0.2 mL of silver nitrate (AgNO 3 ) solution, shake by hand to mix well. Continue to add 70 μl of ascorbic acid (AA) aqueous solution with a concentration of 78.8 mM to the above solution, and shake it by hand to mix evenly, so that the color of the solution becomes colorless. Then a...

no. 2 example

[0096] One-step green and efficient surface functionalization modification of GNRs in ionic liquids.

[0097] Preliminary step, using the classic seed growth method to prepare GNRs with uniform size and good dispersion ( Figure 1a ), specific method with reference to embodiment one.

[0098] Next, GNRs were modified by surface functionalization in ionic liquids:

[0099] Step (1), preparing an aqueous phase gold nanoparticle solution. In this step, the above-mentioned 1.5mL prepared GNRs were transferred to a centrifuge tube, and centrifuged twice at 12000rpm / 20min at a temperature of 25-60°C. Pure water or pH 5.5-7.0 phosphate buffer solution for redispersion.

[0100] Step (2), dissolving MUA into ionic liquid to obtain a 2.35mM 150μL reaction system. Then, 100 μL of LGNRs in step (1) was added dropwise to the reaction system under the condition of vigorous vortexing at 3000 rpm (MUA / [BMIM]Tf 2 N).

[0101] Step (3), when all GNRs are transferred from the aqueous phas...

no. 3 example

[0105] Two-step green and efficient surface functionalization modification of GNRs in reusable ionic liquids.

[0106] Preliminary steps: GNRs with uniform size and good dispersion were prepared by classical seed growth method ( Figure 1a ), the specific method refers to the first embodiment.

[0107] Next, GNRs were modified by surface functionalization in ionic liquids:

[0108] Step (1), preparing an aqueous phase gold nanoparticle solution. First, transfer the above 1.5mL prepared GNRs to a centrifuge tube, perform two centrifugation at 12000rpm / 20min at a temperature of 25-60°C, remove the supernatant after centrifugation, and wash the remaining part with 100μL ultrapure water Or phosphate buffer solution (PH5.5-7.0) to re-disperse.

[0109] Step (2), 100 μ LGNRs in step (1) is transferred to the ionic liquid ([BMIM]Tf 2 N).

[0110] Step (3), when all GNRs are transferred from the aqueous phase to [BMIM]Tf 2 After N phase ( figure 2 ), plus surface modification m...

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Abstract

The invention provides a method for modifying heterogeneous surfaces of gold nanoparticles through hydrophobic ionic liquid, and aims at quickly and efficiently replacing CTAB (Cetyltrimethyl Ammonium Bromide) molecules on the surfaces of the gold nanoparticles with MUA (11-Mercaptoundecanoic Acid) by twice phase transfer. The method is characterized in that the ionic liquid [BMIM] Tf2N is used as a good solvent for extracting the gold nanoparticles from a water phase as well as weakening the dense arrangement of the CTAB on the surface of nanogold, and thus MUA can be well combined with the gold surface; in particular, the gold nanoparticles modified by MUA are water-soluble due to the carboxyl on the surfaces, so that the water phase can be quickly returned by transferring, and as a result, hydrosol of the surface-modified nanogold can be obtained. The method can solve the aforementioned reported shortages of incomplete surface decoration, complex operation and time consumption. With the adoption of the method, the surface modification can be finished within minutes; nearly all CTAB can be replaced with MUA, so that the biotoxicity can be obviously reduced, and moreover, the convenience for further biomolecule modification is ensured, and the application in the biomedicine can be improved.

Description

technical field [0001] The present invention relates to a modification method, more specifically, to a method for modifying the surface of gold nanoparticles in an ionic liquid, and further, to a method for replacing the surface of gold nanoparticles with MUA in an ionic liquid The CTAB approach. Background technique [0002] Gold nanoparticles have attracted great attention from the fields of materials science and biochemistry due to their adjustable shape and size, special optical properties, photothermal effects, and easy coupling of biomolecules. Gold nanorods (GNRs) are rod-shaped gold nanoparticles with continuously adjustable length from 20nm to 200nm and width from 5nm to 100nm. By changing the aspect ratio of GNRs, its longitudinal surface plasmon resonance absorption can be adjusted from the visible region to the near-infrared region (The Journal of Physical Chemistry B1999; 103:8410-26). For organisms, the radiation in the near-infrared band has a window effect, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B22F1/00B82Y40/00
CPCB82Y40/00B22F1/054B22F1/145
Inventor 袁菁苏林嘉
Owner CAPITAL NORMAL UNIVERSITY
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