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Functional wound surface repairing material and preparation method thereof

A wound repair and functional technology, applied in medical science, bandages, etc., can solve the problems of difficult wound healing, easy adhesion of bacteria, and severe infection caused by growth and reproduction, so as to achieve the goal of not easy to reunite or settle, reduce scar formation, and promote wound healing. The effect of healing growth

Inactive Publication Date: 2016-03-09
HUAZHONG NORMAL UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Repair materials based on bioactive glass have excellent biological activity, and their application in tissue repair and replacement is becoming more and more clinical. However, many studies in recent years have shown that when bioactive glass contacts human tissue, a layer of protein is formed on the surface of the material. Bacteria can easily adhere to the membrane, and then grow and reproduce, resulting in serious infection, which makes it difficult for the wound to heal

Method used

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  • Functional wound surface repairing material and preparation method thereof

Examples

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Effect test

Embodiment 1

[0023] A functional wound repair material, prepared by the following method:

[0024] (1) Preparation of bioactive glass: take 5g calcium silicate, 0.5g calcium hydrogen phosphate, 0.5g disodium hydrogen phosphate and 3.5g sodium silicate, make a uniform melt at a temperature of 1250°C, cool, Crush to 20-100um to obtain bioactive glass;

[0025] (2) Preparation of silver-loaded bioactive glass powder: Weigh 7 g of bioactive glass, add to 50 g of aqueous solution containing 0.5 g of silver nitrate, stir and react at 40° C. for 4 hours, filter, wash and dry to obtain silver-loaded bioactive glass;

[0026] (3) Preparation of functional wound repair materials: Weigh 160g of deionized water, add the silver-loaded bioactive glass prepared in step (2), 0.2g of chloramphenicol, 15g of hyaluronic acid, stir evenly, and defoam Finally, functional wound repair materials were obtained.

Embodiment 2

[0028] A functional wound repair material, prepared by the following method:

[0029] (1) Preparation of bioactive glass: take 5.2g calcium silicate, 1g calcium hydrogen phosphate, 1.5g disodium hydrogen phosphate and 3.7g sodium silicate, make a uniform melt at a temperature of 1250°C, cool, Crush to 20-100um to obtain bioactive glass;

[0030] (2) Preparation of silver-loaded bioactive glass: Weigh 7 g of bioactive glass, add to 50 g of aqueous solution containing 0.6 g of silver nitrate, stir and react at 50° C. for 4 h, filter, wash and dry to obtain silver-loaded bioactive glass;

[0031] (3) Preparation of functional wound repair material: take 120g deionized water, add the silver-loaded bioactive glass prepared in step (2), 0.4g aureomycin, 20g chitosan, stir evenly, remove After soaking, a functional wound repair material was obtained.

Embodiment 3

[0033] A functional wound repair material, prepared by the following method:

[0034] (1) Preparation of bioactive glass: Weigh 5.5g of calcium silicate, 1.5g of calcium hydrogen phosphate, 1g of disodium hydrogen phosphate and 4g of sodium silicate, make a uniform melt at a temperature of 1250°C, cool and pulverize to 20-100um to obtain bioactive glass;

[0035] (2) Preparation of silver-loaded bioactive glass: Weigh 7 g of bioactive glass, add it to 50 g of aqueous solution containing 0.7 g of silver nitrate, stir and react at 60° C. for 4 hours, filter, wash and dry to obtain silver-loaded bioactive glass;

[0036] (3) Preparation of functional wound repair materials: Weigh 80 g of deionized water, add the silver-loaded bioactive glass prepared in step (2), 0.6 g of oxytetracycline, 10 g of chitosan, and 15 g of sodium alginate , stir evenly, and get a functional wound repair material after defoaming.

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Abstract

The invention belongs to the field of medical materials and particularly relates to a functional wound surface repairing material and a preparation method thereof. The wound surface repairing material is prepared by compounding 7-14 parts of bioactive glass, 0.5-0.7 part of silver nitrate, 0.2-0.6 part of antibiotics, 15-25 parts of degradable polymer and 80-160 parts of deionized water. The functional wound surface repairing material is loaded with silver ions and antibiotics, wherein the silver ions and the antibiotics respectively have bactericidal performance, and the silver ions can enable the antibiotics to more easily enter bacteria to exert synergistic action by increasing the generation of oxygen free radicals and increasing the permeability of bacterial membranes, so that the functional wound surface repairing material has relatively strong antibacterial performance and can solve the problem that bacteria are easy to adhere to the existing wound surface repairing material to cause infection and then the curative effect is not ideal.

Description

technical field [0001] The invention belongs to the field of medical materials and relates to active wound repair materials, in particular to a functional wound repair material and a preparation method thereof. Background technique [0002] There are many repairing materials for treating wounds in the prior art, but they need to be improved in terms of penetration and absorption of wounds, promoting blood vessel growth, promoting wound healing and reducing scar formation, especially for hemorrhoids, burns, diabetic ulcers and refractory wounds caused by unknown reasons. , the treatment effect is worse, it brings serious mental and physical pain to the patient, and increases the economic burden of the patient. [0003] After decades of research, it has been found that bioactive glass has certain cell and gene activation effects, which can not only promote the proliferation and differentiation of bone cells, form chemical bonds with bone tissue, but also combine with soft tiss...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L26/00
CPCA61L26/0066A61L26/008A61L26/009A61L26/0095A61L2300/104A61L2300/406C08L5/08C08L5/04C08L29/04
Inventor 暴峰高洁陈凯悦
Owner HUAZHONG NORMAL UNIV
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