Application of Malong (ephedra and lumbricus) traditional Chinese medicinal composition

The technology of a composition and traditional Chinese medicine is applied in the application field of Malong traditional Chinese medicine composition, which can solve problems such as drug resistance, cure the symptoms but not the root cause, and achieve the effect of significant curative effect, clinical significance and no drug dependence.

Inactive Publication Date: 2016-03-23
HAINAN HULUWA PHARMA GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Allergic cough is currently treated with hormonal drugs. However, traditional hormonal chemical drugs are only used for symptomatic treatment at the onset of the disease, which has the limitation of treating the symptoms but not the root cause. With the prolongation of taking time, there are different degrees of adverse reactions. possible drug resistance

Method used

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  • Application of Malong (ephedra and lumbricus) traditional Chinese medicinal composition
  • Application of Malong (ephedra and lumbricus) traditional Chinese medicinal composition
  • Application of Malong (ephedra and lumbricus) traditional Chinese medicinal composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] (1) Soak 300g of raw ephedra, 500g of bitter almonds, 500g of peach kernels, 500g of peucedanum, 500g of pedicel, and 500g of forsythia in water for more than 0.5 hours, steam distillation to extract volatile oil for 2 to 3 hours, collect volatile oil, and dregs for later use.

[0026] (2) Combine 400g of earthworm, 600g of pinellia chinensis, 600g of loquat leaves, 500g of mulberry bark, 1800g of raw gypsum, and 300g of licorice, and combine the medicinal residues in step (1), add 6 times the weight of the medicinal materials and boil them in water. 50°C, warm immersion 3 times, 2 hours each time, combine the warm immersion solution, discard the dregs, and extract the solution for later use;

[0027] (3) The extract from step (2) was left to stand, filtered, and the filtrate was concentrated under low pressure (vacuum degree 0.05MPa, temperature 55°C, relative density of the concentrated solution was 1.125), and set aside;

[0028] (4) Spray-dry the concentrate obtaine...

Embodiment 2

[0030] The therapeutic effect of embodiment 2 on guinea pig allergic cough

[0031] Select 60 healthy guinea pigs, both male and female, and randomly divide them into normal group and model group. 10 of the normal group were raised normally, and the rest of the guinea pigs were used for modeling. On the first day, each guinea pig was intramuscularly injected with 0.5 ml of 4% OVA (ovalbumin) solution, and at the same time, 0.2 ml of 2% aluminum hydroxide gel was injected intraperitoneally. From the 14th day, the guinea pigs in the model group were challenged with 1% OVA solution in a multi-functional cough and asthma induction instrument for 1 min, once every other day, a total of 7 times. After the last excitation, use 0.2×10 -2 mol / L capsaicin is sprayed 2min in the multi-functional instrument for inducing cough and asthma to induce cough, select guinea pigs with more than 8 times of cough times, and be randomly divided into model group and test group according to the numbe...

Embodiment 3

[0036] Example 3 Effects on Ammonia Caused by Normal Mouse Cough

[0037] Select healthy ICR mice, half male and half male, and are randomly divided into normal control group, positive medicine Kebiqing 26mg / kg group, Chuanbei Xueli Gao 3.9g / kg group, test group (the test group applies the antiallergic granule of embodiment 1, The dosage is based on the amount of crude drug, which is respectively 3.75, 7.5, 15, and 30 g / kg), and 10 animals in each group were administered by gavage. Give an equal volume of 0.5% CMC-Na suspension, 1 hour after the last administration, put the mice in a multi-functional cough and asthma inducer, add 25% ammonia water, spray for 30 seconds, observe and record the cough latency of the mice and within 2 minutes The number of coughs, the results are shown in Table 2.

[0038] Table 2 The effect of Malong traditional Chinese medicine composition on ammonia water-induced cough in mice

[0039]

[0040] compared with control group * P** P<0.01 ...

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Abstract

The invention discloses application of a Malong (ephedra and lumbricus) traditional Chinese medicinal composition. The Malong traditional Chinese medicinal composition is used for preparing an anti-allergic medicine; and the traditional Chinese medicinal composition consists of the following components in parts by weight: 280-320 parts of raw ephedra, 280-420 parts of lumbricus, 280-520 parts of bitter apricot kernel, 280-520 parts of peach kernel, 280-520 parts of radix peucedani, 280-520 parts of radix stemonae, 280-520 parts of fructus forsythia, 580-630 parts of rhizoma pinelliae preparata, 580-630 parts of folium eriobotryae, 280-520 parts of white mulberry root-bark, 1800 parts of gypsum and 280-320 parts of liquorice root. The anti-allergic medicine prepared by the Malong traditional Chinese medicinal composition has significant effects on relieving cough, preventing asthma, eliminating phlegm and resisting allergy; and the Malong traditional Chinese medicinal composition has a significant effect on treating allergic cough.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine preparations, and in particular relates to the application of a Malong traditional Chinese medicine composition. Background technique [0002] Allergic cough is also known as allergic bronchitis or cough variant asthma. The clinical features of allergic cough are: chronic cough without reason for more than two months, with paroxysmal irritating dry cough, or a small amount of white foam Phlegm; inhalation of smoke or chemical odors such as paint and dichlorvos can be aggravated; application of various antibiotics is ineffective, and there is no obvious abnormality in filming or CT examination. 40% of patients may be combined with symptoms of allergic rhinitis such as sneezing and runny nose, which many foreign doctors call allergic rhinitis-bronchitis. [0003] The pathogenesis of allergic cough and allergic asthma is similar, and the etiology of allergy is numerous and complicated, bu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/904A61P37/08A61P11/14A61P11/06A61P11/10A61K35/62A61K33/06
CPCA61K36/17A61K9/1652A61K33/06A61K35/62A61K36/23A61K36/484A61K36/605A61K36/634A61K36/73A61K36/736A61K36/8888A61K36/904A61K2236/331A61K2236/39A61K2300/00
Inventor 刘景萍刘全国陈克领林文君
Owner HAINAN HULUWA PHARMA GRP CO LTD
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