Tilmicosin injection as well as preparation method and application thereof

A technology of tilmicosin injection, applied in the field of tilmicosin injection and its preparation and application, can solve problems such as tachycardia and weakened contractility, reduce toxic and side effects, prevent needle infection, and simplify immunization program effect

Active Publication Date: 2016-04-06
TIANJIN ZHONGSHENG TIAOZHAN BIOTECH
View PDF6 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, tilmicosin injection must be used with caution. In the third chapter of the second edition of the "Handbook of Veterinary Medicine" edited by Zeng Zhenling, when introducing the macrolide tilmicosin, in the "Note" column (page 89) Also pointed out: "The target organ of the toxicity of this product is the heart, which can cause tachycardia and weakened contractility.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Tilmicosin injection as well as preparation method and application thereof
  • Tilmicosin injection as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] A kind of tilmicosin injection is made up of tilmicosin, astragaloside IV, ATP, cosolvent, antioxidant, stabilizer and injection water, wherein every 100ml solution contains tilmicosin 10g, astragaloside IV 1g , ATP 1g, lactic acid 5g, sodium bisulfite 0.1g, propylene glycol 15g, and water for injection to make up to 100ml.

[0034] Its preparation method is:

[0035] (1) Dissolve sodium bisulfite, ATP, and lactic acid in water for injection respectively, add tilmicosin, and stir to dissolve.

[0036] (2) Add astragaloside IV into propylene glycol and stir until dissolved. If necessary, it can be heated slowly, and the heating temperature is 55-60°C.

[0037] (3) Mix the two, adjust the pH value to 5.5 with lactic acid, dilute with water for injection, filter and sterilize.

Embodiment 2

[0039] A kind of tilmicosin injection is made up of tilmicosin, astragaloside IV, ATP, cosolvent, antioxidant, stabilizer and injection water, wherein every 100ml solution contains tilmicosin 20g, astragaloside IV 2g , ATP1.5g, citric acid 15g, Diaobaikuai 0.2g, polyethylene glycol-20015ml, water for injection to make up to 100ml.

[0040] Its preparation method is:

[0041] (1) Dissolve Diaobaikuai, ATP, and citric acid in water for injection, add tilmicosin, and stir to dissolve it.

[0042] (2) Add astragaloside IV into polyethylene glycol-200 and stir until dissolved. If necessary, it can be heated slowly, and the heating temperature is 55-60°C.

[0043] (3) Mix the two, adjust the pH value to 5.5 with citric acid, dilute with water for injection, filter and sterilize.

Embodiment 3

[0045] A kind of tilmicosin injection is made up of tilmicosin, astragaloside IV, ATP, cosolvent, antioxidant, stabilizer and injection water, wherein every 100ml solution contains tilmicosin 30g, astragaloside IV 3g , ATP 1.5g, Phosphoric Acid 12.5ml, Sodium Bisulfite 0.1g, Hangbaikuai 0.1g, Propylene Glycol 5ml, Polyethylene Glycol-200 15ml water for injection to make up to 100ml.

[0046] Its preparation method is:

[0047] Dissolve sodium bisulfite, diaobaikuai, ATP, and phosphoric acid in water for injection respectively, add tilmicosin, and stir to dissolve it.

[0048] Add astragaloside IV into the mixed solution of propylene glycol and polyethylene glycol-200 and stir until dissolved. If necessary, it can be heated slowly, and the heating temperature is 55-60°C.

[0049] Mix the two, adjust the pH value to 5.5 with phosphoric acid, dilute with water for injection, filter and sterilize.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention provides tilmicosin injection as well as a preparation method and an application thereof. The tilmicosin injection is prepared from the following components in parts by weight: 10-50 parts of tilmicosin, 1-5 parts of astragaloside, 0.5-2 parts of ATP, 5-20 parts of a cosolvent, 0.1-0.5 part of an antioxidant, and 15-30 parts of a stabilizer. The tilmicosin injection is stable in property, remarkable in effect, and small in irritation and safe to the injected part, and can be mixed with inactivated vaccines for injection, so that the clinic application of the tilmicosin injection is expanded.

Description

technical field [0001] The invention relates to a tilmicosin injection and a preparation method and application thereof. Background technique [0002] Tilmicosin belongs to macrolide antibiotics for animals, and has good antibacterial activity against Gram-positive bacteria, Gram-negative bacteria, anaerobic cocci, Legionella, Mycoplasma, Chlamydia, etc. Linear bacilli, Pasteurella and mycoplasma have strong activity, and are widely used in the prevention and treatment of diseases such as bovine mastitis, swine mycoplasma pneumonia and livestock and poultry mycoplasma infection. It is sensitive to more than 95% of hemolytic Pasteurella, and its pharmacological effects are relatively Tylosin, erythromycin thiocyanate and other drugs were 3 to 5 times higher. [0003] However, tilmicosin injection must be used with caution. In the third chapter of the second edition of the "Handbook of Veterinary Medicine" edited by Zeng Zhenling, when introducing the macrolide tilmicosin, in...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K31/7076A61K31/7048A61K31/706A61K39/295A61P31/04A61P31/12A61P31/14A61P37/04A61K39/17A61K39/145A61K39/02
CPCA61K9/0019A61K9/08A61K31/7048A61K31/706A61K31/7076A61K39/0241A61K39/12A61K2039/70C12N2760/16134C12N2760/18134A61K2300/00
Inventor 王猛王建程雪娇朱士江张立会王勇焦晓军甄盼盼杨雪王宇鹏于小婷范庆增姜淋洁崔志刚余贵菊李丽琴李玲
Owner TIANJIN ZHONGSHENG TIAOZHAN BIOTECH
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap