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Medium-chain triglyceride (MCT) nano-emulsion and preparation method thereof

A technology of triglyceride and nanoemulsion, which is applied in the direction of pharmaceutical formulation, emulsion delivery, and medical preparations of non-active ingredients, etc. It can solve the problems of affecting curative effect, reducing bioavailability, uncontrolled fat emulsion particle size and peroxide value and other problems, to achieve the effect of promoting cholesterol metabolism, increasing absorption speed, and increasing the nutritional content of lecithin

Active Publication Date: 2016-04-13
GUANGZHOU HANFANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] With the in-depth research on fat metabolism, the characteristics of medium-chain triglycerides (MCT) are increasingly revealed, which has attracted the attention of the medical community, but direct oral administration of medium-chain triglycerides (MCT) will cause nausea, vomiting, diarrhea or cramping abdominal pain, etc. Uncomfortable symptoms, thereby reducing its bioavailability in vivo and affecting its curative effect
At present, patents and documents disclose some preparation methods of fat emulsions, which basically do not control the particle size and peroxide value of fat emulsions, and are rarely reported as nanoemulsions.

Method used

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  • Medium-chain triglyceride (MCT) nano-emulsion and preparation method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] A. Water phase: Mix 24g of glycerin, 805g of Tween and 880ml of purified water evenly, and preheat to 60°C, set aside;

[0022] B. Oil phase: Cut 50g of medium chain triglyceride (MCT) and 25g of egg yolk lecithin at high speed until mixed evenly, set aside;

[0023] C. Slowly pour the oil phase material into the water phase material, and use a high-speed shear mixer at 100,000 revolutions per minute, shear and stir for 5 minutes, repeat 3 times, and prepare colostrum;

[0024] D. Under the condition of a pressure of 103Mpa, the colostrum was repeatedly homogenized 3 times by using a micro-fluid high-pressure homogenizer to make oral medium-chain triglyceride (MCT) nanoemulsion.

[0025] E. Filter and sterilize the homogenized emulsion through a 0.4 μm microporous membrane filter, pour it into a packaging container in a sterile GMP clean environment, fill it with nitrogen and seal it.

[0026] Note: heat treatment 1 : After heating at 121 degrees for 30 minutes, centr...

Embodiment 2

[0029] A. Water phase: Mix 50g of glycerin, 8050g of Tween and 750ml of purified water evenly, and preheat to 50°C, set aside;

[0030] B. Oil phase: shear 100g medium chain triglyceride (MCT) and 25g egg yolk lecithin at high speed until mixed evenly, and set aside;

[0031] C. Slowly pour the oil phase material into the water phase material, and use a high-speed shear mixer at 100,000 revolutions per minute, shear and stir for 5 minutes, repeat 3 times, and prepare colostrum;

[0032] D. Under the condition of a pressure of 103Mpa, the colostrum was repeatedly homogenized twice by using a micro-fluidic high-pressure homogenizer to make oral medium-chain triglyceride (MCT) nanoemulsion.

[0033] E. Filter and sterilize the homogenized emulsion through a 0.4 μm microporous membrane filter, pour it into a packaging container in a sterile GMP clean environment, fill it with nitrogen and seal it.

Embodiment 3

[0035] A. Water phase: Mix 50g of glycerin, 8025g of Tween and 830ml of purified water evenly, and preheat to 70°C, set aside;

[0036] B. Oil phase: 50g of medium chain triglyceride (MCT) and 25g of egg yolk lecithin are sheared at high speed until mixed evenly, and set aside;

[0037] C. Slowly pour the oil phase material into the water phase material, and use a high-speed shear mixer at 100,000 revolutions per minute, shear and stir for 5 minutes, repeat 3 times, and prepare colostrum;

[0038] D. Under the condition of a pressure of 103Mpa, the colostrum was repeatedly homogenized 3 times by using a micro-fluid high-pressure homogenizer to make oral medium-chain triglyceride (MCT) nanoemulsion.

[0039] E. Filter and sterilize the homogenized emulsion through a 0.4 μm microporous membrane filter, pour it into a packaging container in a sterile GMP clean environment, fill it with nitrogen and seal it.

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Abstract

The invention discloses medium-chain triglyceride (MCT) nano-emulsion and a preparation method thereof. The MCT nano-emulsion is prepared from the following components in parts by weight: 10-90 parts of MCT (1), 24-50 parts of glycerinum (2), 1-50 parts of egg yolk lecithin (3), 1-50 parts of Tween 80 (4) and 700-950 parts of purified water (5). The MCT is prepared into oral fatty nano-emulsion, so that the absorbing speed of fatty nutrients is increased. The egg yolk lecithin and the Tween 80 are mixed into an emulsifier, so that lecithin nutrient components are increased, and cholesterol metabolism is facilitated. Through nutrient components such as medium-chain fatty acid and the lecithin, the product plays a very good role in regulating metabolic disturbance of human body fat. Meanwhile, the MCT is prepared into the nano-emulsion, so that the uncomfortable symptoms of nausea, emesis, diarrhea or abdominal spastic pain and the like caused by orally taking of the MCT can be avoided.

Description

technical field [0001] The invention belongs to the field of enteral nutrition, and in particular relates to a medium-chain triglyceride nanoemulsion and a preparation method thereof. Background technique [0002] Medium-chain triglycerides (MCT) are triglycerides composed of fatty acids containing 6 to 12 carbon atoms. Typical medium-chain triglycerides (MCT) refer to saturated caprylic triglycerides or saturated capric triglycerides or Saturated caprylic-capric mixed triglycerides. After entering the human body, medium-chain triglycerides (MCT) are first hydrolyzed by lipase, then absorbed in the form of glycerol and medium-chain fatty acids, and quickly transferred to the liver. After reaching the liver, medium-chain fatty acids can be quickly oxidized and decomposed to provide energy without causing fat accumulation in the liver. At the same time, medium-chain triglycerides (MCT) can also improve the digestion of minerals and some essential fatty acids to a certain exte...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/107A61K31/23A61K47/24A61K47/26
CPCA61K9/0053A61K9/1075A61K31/23A61K47/24A61K47/26A61K2300/00
Inventor 刘欢罗明琍曾荣华李金华袁诚杨占东谢嘉信
Owner GUANGZHOU HANFANG PHARMA
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