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Osteon myospalacem baileyi compound extract tablets with bone repair effect and preparation method thereof

A compound extract and compound extraction technology, applied in medical preparations containing active ingredients, pill delivery, bone diseases, etc., can solve the problems of weak disintegration and low bioavailability, and achieve the promotion of drug efficacy and bioavailability. The effect of high degree and small amount of auxiliary materials

Inactive Publication Date: 2016-05-04
CHINA ACAD OF SCI NORTHWEST HIGHLAND BIOLOGY INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The second object of the present invention is to provide a preparation method of the said Sialon bone compound extract tablet with bone repairing effect, which overcomes the weak disintegration effect or disintegration when only the disintegrant is added internally or externally. It has the disadvantage of low bioavailability due to not being fine powder after solution, and the preparation process is simple and easy to operate, which is suitable for large-scale production

Method used

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  • Osteon myospalacem baileyi compound extract tablets with bone repair effect and preparation method thereof
  • Osteon myospalacem baileyi compound extract tablets with bone repair effect and preparation method thereof
  • Osteon myospalacem baileyi compound extract tablets with bone repair effect and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] A preparation method of the Theron bone compound extract tablet with bone repair effect:

[0047] Raw materials: in parts by mass, 900 parts of Theron bone compound extract, 50 parts of maltodextrin, 10 parts of starch, 20 parts of microcrystalline cellulose, 10 parts of silicon dioxide, 10 parts of magnesium stearate, xylitol Anhydride monooleate 10 parts, carrageenan 10 parts.

[0048] Preparation method:

[0049] a) by mass parts (300 parts of Theron bone water extract, 100 parts of Theron bone n-butanol extract, 200 parts of Theron bone ethanol extract, 150 parts of Theron bone methanol extract, and Theron bone ethyl acetate 150 parts of ester extract) to prepare the compound extract of Theron bone;

[0050] b) Weighing the prescribed amount of Theron bone compound extract and pulverizing, passing through a 100-mesh sieve, for subsequent use;

[0051] c) Weighing the maltodextrin and xylitol monooleate of the prescribed amount, grinding, adding the compound extra...

Embodiment 2

[0057] A preparation method of the Theron bone compound extract tablet with bone repair effect:

[0058] Raw materials: in parts by mass, 800 parts of theron bone compound extract, 40 parts of maltodextrin, 6 parts of starch, 4 parts of mannitol, 10 parts of sodium carboxymethyl starch, 4009 parts of polyethylene glycol, xylitol Anhydride monooleate 8 parts.

[0059] Preparation method:

[0060] a) by mass parts (300 parts of Theron bone water extract, 100 parts of Theron bone n-butanol extract, 100 parts of Theron bone ethanol extract, 150 parts of Theron bone methanol extract, and Theron bone ethyl acetate 150 parts of ester extract) to prepare the compound extract of Theron bone;

[0061] b) Weighing the prescribed amount of Theron bone compound extract, pulverizing, passing through an 80-mesh sieve, and setting aside;

[0062] c) Weighing the maltodextrin and xylitol monooleate of the prescribed amount, grinding, adding the compound extract of sialon bone in step a) whi...

Embodiment 3

[0068] A preparation method of the Theron bone compound extract tablet with bone repair effect:

[0069] Raw materials: in parts by mass, 900 parts of sialon bone compound extract, 50 parts of maltodextrin, 10 parts of starch, 20 parts of microcrystalline cellulose, 10 parts of silicon dioxide, and 10 parts of magnesium stearate.

[0070] Preparation method:

[0071] a) by mass parts (500 parts of Theron bone water extract, 50 parts of Theron bone n-butanol extract, 50 parts of Theron bone ethanol extract, 150 parts of Theron bone methanol extract, and Theron bone ethyl acetate 150 parts of ester extract) to prepare the compound extract of Theron bone;

[0072] b) Weighing the prescribed amount of Theron bone compound extract and pulverizing, passing through a 100-mesh sieve, for subsequent use;

[0073] c) Weigh the maltodextrin of the prescribed amount, grind it, and add the compound extract of the bone of Sialon in step a) while grinding it, and continue grinding to obtai...

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Abstract

The invention provides osteon myospalacem baileyi compound extract tablets with the bone repair effect and a preparation method thereof. The tablets are mainly prepared from osteon myospalacem baileyi compound extract, maltodextrin, filler, a disintegrating agent, lubricant and the like which are in specific dosages. The tablets have the advantages of being small in auxiliary material quantity, uniform in dispersion of the osteon myospalacem baileyi compound extract, good in disintegrating performance, good in medicine effect, good in stability, high in bioavailability, capable of remarkably promoting bone growth and the like. A specific feeding step is adopted in the preparation method of the tablets, the osteon myospalacem baileyi compound extract is uniformly dispersed, the medicine effect of the obtained osteon myospalacem baileyi compound extract tablets with the bone repair effect is further promoted, and bioavailability is promoted. In addition, the defects that when the disintegrating agent is only added internally or externally, the disintegrating effect is weak, or fine powder is not formed after disintegrating, and therefore bioavailability is low are overcome, and the osteon myospalacem baileyi compound extract tablets are simple in preparation process, easy to operate and suitable for large-scale production.

Description

technical field [0001] The invention relates to the technical field of Chinese patent medicines, in particular to a Sialon bone compound extract tablet with bone repairing effect and a preparation method thereof. Background technique [0002] Although bone tissue is one of the few tissues that can completely regenerate in the body, it is still difficult to repair and rebuild itself if the bone tissue loss exceeds a critical length, that is, a bone defect. Therefore, the repair and reconstruction of bone defects has always been one of the clinical problems in orthopedics, and many scholars have carried out related exploration and research. In 1668, Dutch doctor Job van Meekeren performed the world's first bone graft operation, using a dog's skull to repair a human skull. Although the treatment was terminated because it violated the Christian teachings, it led to the widespread recognition and rapid development of bone grafting technology. In 1820, Walther implemented the fi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/32A61K9/20A61P19/08
CPCA61K35/32A61K9/2059
Inventor 江磊陶燕铎邵贇梅丽娟岳会兰
Owner CHINA ACAD OF SCI NORTHWEST HIGHLAND BIOLOGY INST
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