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Vaccine used for preventing and treating influenza, avian influenza and upper respiratory infection

A technology for upper respiratory tract and bird flu, applied in the field of medicine, can solve the problems of easy to disperse, improper use, easy to infect bird flu virus, etc.

Pending Publication Date: 2016-05-04
程龙
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Existing avian influenza vaccines are mostly made of weakly toxic avian influenza viruses. The existing avian influenza vaccines have defects such as being easily infected with avian influenza viruses if used improperly, the vaccines cannot be used up, and the virus is easily scattered during storage.

Method used

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  • Vaccine used for preventing and treating influenza, avian influenza and upper respiratory infection
  • Vaccine used for preventing and treating influenza, avian influenza and upper respiratory infection
  • Vaccine used for preventing and treating influenza, avian influenza and upper respiratory infection

Examples

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Effect test

Embodiment 1

[0029] Embodiment 1 A kind of vaccine for preventing and treating influenza, bird flu, upper respiratory tract infection

[0030] The vaccine comprises marine algal glycoprotein;

[0031] The marine algae glycoprotein includes 1% sugar and 99% protein by weight content.

[0032] The molecular weight is 0.2kDa;

[0033] The marine algae are: cyanobacteria;

[0034] The sugar is a polysaccharide;

[0035] The polysaccharides include: glucose, galactose, mannose, rhamnose;

[0036] The protein includes: serine, threonine, hydroxylysine, aspartic acid;

Embodiment 2

[0037] Embodiment 2 A kind of vaccine for preventing and treating influenza, bird flu, upper respiratory tract infection

[0038] The vaccine comprises marine algal glycoprotein;

[0039] Said marine algae glycoprotein, by weight content, comprises sugar 5%, protein 82%,

[0040] The molecular weight is 3kDa;

[0041] The marine algae are: cyanobacteria;

[0042] The sugar is a polysaccharide;

[0043] The polysaccharides include: glucose, galactose, mannose, rhamnose;

[0044] The protein includes: serine, threonine, hydroxylysine, aspartic acid;

Embodiment 3

[0045] Embodiment 3 A kind of vaccine for preventing and treating influenza, bird flu, upper respiratory tract infection

[0046] The vaccine comprises marine algal glycoprotein;

[0047] Said marine algal glycoprotein, by weight content, comprises sugar 17%, protein 75%,

[0048] The molecular weight is 32kDa;

[0049] The marine algae is: green algae;

[0050] The sugar is a polysaccharide;

[0051] The polysaccharides include: glucose, galactose, mannose, rhamnose;

[0052] The protein includes: serine, threonine, hydroxylysine, aspartic acid;

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Abstract

The invention provides a vaccine used for preventing and treating influenza, avian influenza and upper respiratory infection. The vaccine is glycoprotein or a mixture of polysaccharide and protein or polypeptide or protein. After the vaccine prepared by the invention is used for immunizing SPF chickens, AIV-H5 (Avian Influenza Virus-H5) avian influenza virus antibodies are generated; after the SPF chickens are immunized, AIV-H5 avian influenza viruses can be effectively resisted and the protection rate reaches 80 percent to 93.3 percent; after the SPF chickens are immunized, NDV chicken Newcastle disease antibodies; after the SPF chickens are immunized, NDV chicken Newcastle disease viruses can be effectively resisted and the protection rate reaches 76.7 percent to 96.7 percent. The vaccine provided by the invention has functions of preventing and treating respiratory system diseases, and broad-spectrum anti-virus, anti-inflammatory, anticoagulation, bacteria resisting, antipyretic and immunity adjusting functions. The vaccine provided by the invention is safe and efficient, has no side effect, and has an obvious curative effect on preventing and treating the avian influenza; avian influenza-H5 antibody detection is negative, so that the vaccine can be used for killing the avian influenza-H5 viruses.

Description

technical field [0001] The invention relates to a vaccine for preventing and treating influenza, bird flu and upper respiratory tract infection, belonging to the technical field of medicine. Background technique [0002] Avian influenza (Avian influenza, AI) is the abbreviation of avian influenza, the acute respiratory infectious disease that is caused by a variety of poultry infection caused by avian influenza virus (Avian influenza virus, AIV), can also infect human beings, has been recognized by the International Veterinary Bureau (OIE) and my country The "Livestock and Poultry Epidemic Prevention Regulations" listed it as a Class A severe infectious disease. [0003] Influenza viruses belong to the Orthomyxoviridae family Influenzavirus genus, which contain enveloped, polymorphic negative-strand RNA viruses. Influenza viruses can be divided into three types: A (A), B (B) and C (C) according to the differences in the internal nucleoprotein (NP) and matrix protein (MP) ant...

Claims

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Application Information

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IPC IPC(8): A61K39/00A61P31/16A61P11/00A61P31/14
CPCA61K39/00A61K38/00
Inventor 程龙徐宝贞程潜
Owner 程龙