Synthesis method based on diaminomaleonitrile asymmetric Schiff base

Abstract

The invention discloses a synthesis method based on diaminomaleonitrile asymmetric Schiff base. The asymmetric Schiff base synthesis method, namely an acyl chloride occupation method, is efficient, simple and wide in application and is explored by virtue of high acyl chloride reaction activity. The preparation method of the base comprises the following steps: enabling reaction of diaminomaleonitrile and acetyl chloride in an ice water bath to obtain a monoacetylated product Ac-DAMN, and then enabling a condensation reaction with salicylaldehyde to obtain an asymmetric Schiff base ligand; enabling reaction of the ligand and Zn(NO3)2*6H2O in a methanol solution to obtain a coordination crystal. The method is simple in reaction, mild in condition, easy to operate and high in product yield, and is a novel technology for designing and synthesizing the asymmetric Schiff base through the acyl chloride occupation method and further synthesizing the asymmetric Schiff base complex.

Description

technical field [0001] The invention belongs to the field of synthesis of organic functional ligands, in particular to a synthesis method based on diaminomaleonitrile asymmetric Schiff base ligands. Background technique [0002] Schiff bases are a class of important organic molecules containing C=N double bonds based on aldehyde-amine condensation reactions. In view of the abundance of various aldehyde and amine compounds, Schiff bases have developed into a large class of functional organic molecules, especially It is a flexible substituent group on the Schiff base and the N atom in the C=N group of the Schiff base can become a donor interacting with metal ions. Therefore, the Schiff base is another important class of organic ligands. . At present, various Schiff base complexes have been developed and have been applied in the fields of catalytic industry, biopharmaceuticals, and functional materials. Most of these Schiff base ligands and their complexes are symmetrical mol...

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Problems solved by technology

At present, methods for synthesizing asymmetric Schiff bases include template method, direct synthesis method, space-occupying method, etc., wherein the template method needs to add a masking agent or precipitant; the direct synthesis method has a low yield of Schiff base and a large amount of solvent consumption, etc. Some factors are subject to certain restrictions; Elder excess diamine method [R.C.Elder, Aust.J.Chem.31 (1978) 35-45], Sinn piperidine method [R.Atkins, G.Brewer, E.Kokot, G.M.Mockler , Inorg.Chem.24 (1985) 127-134] and Yao Kemin's asymmetric diamine method [K.Yao, W.Zhou, G.Lu, Science in China Series B-Chemistry, 42 (1999) 164-169] and other methods are not It has wide applicability and is only effective for the synthesis of a certain Schiff base

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