Electrochemical catalytic synthesis method of aromaticnitrile

Abstract

The invention discloses an electrochemical catalytic synthesis method of aromaticnitrile. Aromatic aldehyde is used as a raw material, HMDS (hexamethyldisilazane) is used as a nitrogen source, a three-electrode system is adopted, a negative electrode and a positive electrode adopt platinum electrodes, and a 0.1mol / l silver nitrate acetonitrile solution is used as a reference electrode; aromatic aldehyde, HMDS, TEMPO (2,2,6,6-tetramethyl-1-piperidine-N-oxyl free radicals) and acetic acid are added to an electrolyte acetonitrile solution with certain concentration, the mixture is stirred for an electrolytic reaction at the temperature of 5-40 DEG C and under the constant voltage of 0.5-8.0 V for 5-30 h, a reaction liquid is subjected to aftertreatment, and a product, namely, aromaticnitrile, is obtained; an electrolyte refers to sodium perchlorate, sodium periodate or sodium tetrafluoroborate. The method is simple and safe to operate and easy to implement.

Description

technical field [0001] The invention belongs to the technical field of chemistry, in particular to an electrochemical catalytic synthesis method of aromatic nitriles. Background technique [0002] Nitrile compounds are important building blocks in organic synthesis, especially aromatic nitriles are the key structural units of many dyes, medicines, pesticides and electronic materials. Nitrile compounds are also important intermediates in organic synthesis because the cyano groups contained in them have the ability to transform into other important functional groups such as amino groups, amido groups, aldehyde groups, carboxyl groups, and ester groups. The most traditional synthetic method of aromatic nitriles is through Sandmeyerreaction or Rosenmund–vonBraun reaction, but these two methods have serious defects, both require the use of stoichiometric CuCN, and the reaction conditions are relatively severe. Since then, the cyanation reaction route of aromatic halides catalyze...

AI Technical Summary

Problems solved by technology

The disadvantages of this type of synthesis method are: (1) the cyanogen sources used are generally poisonous, and care must be taken during use to avoid the generation of toxic HCN; (2) stoichiometric metal wastes are inevitably generated, resulting in (3) The control requirements of the reaction process are relatively strict

Aromatic nitriles can also be synthesized from aldoximes, but often have the disadvantages of low product yields and excessive use of toxic reagents

Considering the convenience of the source of raw materials, people pay more and more attention to the synthesis methods using aldehydes, alcohols or acids as raw materials, and urea, ammonia or hydroxylamine as nitrogen sources. However, in most of these reported methods, the use of transition metals and toxic reagents are still unavoidable

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