Films and methods of manufacture
A rate control, flexible body technology, applied in pharmaceutical formulations, prostheses, fixators, etc., can solve the problems of amplification, supervision, economic and logistics burden, etc., and achieve the effect of improving tactile sensation
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Image
Examples
example 1
[0236] Membrane Preparation: Membranes were prepared from a copolymer comprising approximately: 70% glycolic acid, 17% caprolactone, 5% lactic acid, and 8% trimethylene carbonate (US Surgical, North Haven, CT). The copolymer was dissolved in dimethyl sulfoxide (DMSO) at a concentration of 20% by weight and cast as a film on a 20 cm x 20 cm glass plate, or mixed with 5% or 10% gentamicin sulfuric acid and then cast . The cast films were dried in air at 60 °C for at least 12 hours to remove the solvent, then removed from the glass plate and stored under vacuum for further testing. The finished film has a thickness of 0.06±0.01 mm.
[0237] Tensile test: Tensile break test was performed on 10 mm x 80 mm strips cut from cast film according to ASTM D882 at room temperature on an Instron test stand (type 3342) using a tensile rate of 20 mm / s. The initial yield stress obtained by testing at t=0 is as follows Figure 12 As shown, the elongation of the membrane under yield as Figu...
example 2
[0241] In an exemplary embodiment, the implant is tested by implanting it in a sheep. The implant is a metal plate into which a tubular, thin (0.05-0.08mm), transparent polymer sleeve is carefully slid onto the metal plate just before surgical insertion and attachment to the bone. The sleeves are a tight fit and completely cover the metal plate over the entire length, however the sleeves are open at both ends of the plate. The cannula was constructed of a synthetic copolyester (glycolide, caprolactone, trimethylene carbonate, lactide) with 1.5 mm diameter holes equally spaced throughout the cannula. One set of tubes contained triclosan (2,4,4'-trichloro-2'-hydroxydiphenyl ether) at a concentration of 1%, one set of tubes contained gentamicin at a concentration of 10%, and one set of Tubes contained a combination of triclosan (1%) and gentamicin (10%). Concentrations of gentamicin and triclosan were chosen based on in vitro testing to determine the therapeutic window of each ...
example 3
[0246] In an exemplary embodiment, membrane 10 is fabricated by the following method:
[0247] Determination of water content of gentamicin:
[0248] The water content of gentamicin sulfate powder was measured by the loss on drying method. About 0.5 g of gentamicin was weighed in a glass jar, then heated to 110° C. under vacuum for 3 hours, and then weighed again. The weight loss was recorded as the moisture content, which was used to calculate the percent moisture.
[0249] Solution mixing:
[0250] Weigh 14.69 grams of Gentamicin Sulfate powder to compensate for the percent water content calculated above. This was mixed into 400 g of DMSO solvent in a 1 liter vessel using a paddle stirrer. The mixture was stirred for 30 minutes until the gentamicin was evenly distributed. 100 g of a copolymer comprising glycolic acid, caprolactone, lactic acid and trimethylene carbonate monomers were added to the suspension and the mixing vessel was heated to 65°C. Mixing was continued...
PUM
| Property | Measurement | Unit |
|---|---|---|
| thickness | aaaaa | aaaaa |
| thickness | aaaaa | aaaaa |
| thickness | aaaaa | aaaaa |
Abstract
Description
Claims
Application Information
Login to View More