A kind of method and application of regulating biological activity and bacteriostasis performance of silicon nitride ceramics

A technology of silicon nitride ceramics and biological activity, applied in the field of silicon nitride ceramics, can solve the problems of poor biological activity, poor stability in vivo, low bonding strength between coating and substrate, etc., achieve low cost, easy control of conditions, and energy saving Effect

Active Publication Date: 2018-06-19
SUZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The current bioceramics are either poor in biological activity or need to be treated with biological coating on the surface, but the coating treatment often has low bonding strength between the coating and the substrate, or poor stability in the body, which limits its application in the biomedical field. application

Method used

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  • A kind of method and application of regulating biological activity and bacteriostasis performance of silicon nitride ceramics
  • A kind of method and application of regulating biological activity and bacteriostasis performance of silicon nitride ceramics
  • A kind of method and application of regulating biological activity and bacteriostasis performance of silicon nitride ceramics

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] The silicon nitride ceramic sheet with a size of 10mm×10mm×2mm was ultrasonically cleaned with acetone, methanol, ethanol, and deionized water in sequence, each time for 10 minutes, and dried naturally for later use. The cleaned silicon nitride ceramic sheet was placed in In a 100ml PTFE beaker, add 20ml of a solution with a pH of 3 and a conductivity of 1×10 -4 S / m hydrofluoric acid solution, let it stand at 20°C for 200 minutes, then take it out, wash it with a large amount of deionized water, and dry it at 60°C. Its scanning electron microscope appearance is as follows figure 1 As shown, the contact angle as figure 2 shown.

[0034] The silicon nitride ceramics obtained in Example 1, unmodified silicon nitride ceramics and bioglass were sterilized with 75vol% alcohol for 2 hours, washed three times with phosphate buffered saline (PBS), used for cell experiments, and observed in vitro biological activity. The cells were planted on the surface of the material, and...

Embodiment 2

[0039]The silicon nitride ceramic sheet with a size of 10mm×10mm×2mm was ultrasonically cleaned with acetone, methanol, ethanol, and deionized water in sequence, each time for 15 minutes, and dried naturally for later use. The cleaned silicon nitride ceramic sheet was placed in In a 100ml PTFE beaker, add 20ml of a solution with a pH of 5 and a conductivity of 6×10 -4 In the S / m hydrofluoric acid solution, let it stand at 60°C for 100 minutes, then take it out, wash it with a large amount of deionized water, and dry it at 60°C. Its scanning electron microscope appearance is similar to that of Example 1, and the contact angle is 30°.

[0040] The silicon nitride ceramics obtained in Example 2, the unmodified silicon nitride ceramics and the bioglass were subjected to an osteoblast (MC3T3-E1) proliferation experiment. After the sample was sterilized by 75vol% alcohol for 2 hours, it was washed three times with PBS. The cells were planted on the surface of the material, and the ...

Embodiment 3

[0043] The silicon nitride ceramic sheet with a size of 10mm×10mm×2mm was ultrasonically cleaned with acetone, methanol, ethanol, and deionized water in sequence, each time for 20 minutes, and dried naturally for later use. The cleaned silicon nitride ceramic sheet was placed in In a 100ml PTFE beaker, add 20ml of pH 7, conductivity 1×10 -3 S / m mixed solution of hydrofluoric acid and hydrogen peroxide, while adding 1ml of 0.005M AgNO 3 The solution was left to react at 30°C for 60 minutes, then it was taken out and rinsed with a large amount of deionized water, and dried at 60°C. Its scanning electron microscope topography and X-ray energy spectrum are as follows Figure 4 As shown, the silver particles are clearly visible on the surface, which makes the silicon nitride ceramics have antibacterial or antibacterial properties.

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Abstract

The invention discloses a method for regulating bioactivity and antibacterial activity of silicon nitride ceramic and application thereof. The method comprises the following steps: cleaning the silicon nitride ceramic, naturally drying, preparing hydrofluoric acid, an oxydol water solution or a hydrofluoric acid-oxydol mixed water solution as an acidic oxidation electrolyte solution, standing the silicon nitride ceramic in the acidic oxidation electrolyte solution, and after the reaction finishes, carrying out cleaning and drying; or firstly adding a metal ion salt water solution into the acidic oxidation electrolyte solution to prepare a metal-ion-assisted acidic oxidation electrolyte solution, and standing the silicon nitride ceramic in the metal-ion-assisted acidic oxidation electrolyte solution to react. By adopting the traceless treatment technique, the bioactivity and antibacterial activity of the silicon nitride ceramic are regulated on the premise of not changing the surface topography of the silicon nitride ceramic. Thus, the method is simple and easy to implement, and has the advantages of controllable conditions, low cost, energy saving and the like. The modified silicon nitride ceramic can be used as a biologically affine or biologically repulsive surface / interface, an antibacterial or antimicrobial surface / interface, and a medical implant material and substitutes thereof.

Description

technical field [0001] The invention belongs to the technical field of silicon nitride ceramics, and relates to the modification and application of silicon nitride ceramics, in particular to a method for modifying silicon nitride ceramics to adjust its biological activity and antibacterial performance and corresponding applications. Background technique [0002] As the world's population ages, the use of implantable biomaterials in healthcare is becoming more prevalent. In the most representative orthopedic surgery, the demand and use of a series of implantable materials such as artificial joints are showing a rapid growth trend. In the development of more than half a century, the material system of artificial joints (that is, the material system of the ball head to the acetabulum) has experienced several major development stages of metal to metal, metal to cross-linked polymer, and ceramic to ceramic. The development idea is to reduce the generation of prosthesis wear debr...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C04B35/584C04B35/626C04B41/85A61L27/10A61L27/54A61L31/16A61L31/02
CPCA61L27/10A61L27/54A61L31/026A61L31/16A61L2300/104C04B35/584C04B35/62605C04B41/5018C04B41/85C04B2111/00025C04B2111/20C04B41/5009C04B41/5012C04B41/5014C04B41/50C04B41/4535
Inventor 魏东磊杨磊杨惠林李建祥
Owner SUZHOU UNIV
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