Quercetin inclusion compound electrospining nanofilm and preparation method and application thereof

A quercetin and electrospinning technology is applied in the field of quercetin inclusion complex electrospinning nanomembrane, which can solve the problems of poor water solubility, instability of quercetin, limitation of quercetin, etc. Effect

Inactive Publication Date: 2016-05-11
WUHAN POLYTECHNIC UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Due to the instability, poor water solubility and low bioavailability of quercetin, the clinical use of quercetin has been greatly limited.

Method used

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  • Quercetin inclusion compound electrospining nanofilm and preparation method and application thereof
  • Quercetin inclusion compound electrospining nanofilm and preparation method and application thereof
  • Quercetin inclusion compound electrospining nanofilm and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] In this method, firstly, quercetin and β-cyclodextrin are clathrated to increase the solubility of quercetin without changing the internal structure, and then add zein to DMF to make an electrospinning solution , nanomembranes with high stability, high solubility and special functional properties were prepared by electrospinning.

[0030] Inclusion of Quercetin and β-cyclodextrin

[0031] The molar ratio of quercetin and β-cyclodextrin is 1:1, and the clathrate condition is that 1.0 g of quercetin is dissolved in 50 mL of methanol, and then 80 mL is added, stirred at reflux for 1.5 h at 50 ° C, and heated for 0.5 h , remove methanol, cool down naturally, stir for 5 hours, let stand overnight, filter, wash the precipitate with distilled water and methanol, and dry;

[0032] Preparation of electrospinning solution

[0033] The quercetin-β-cyclodextrin inclusion compound, zein, DMF mass volume ratio 4g: 1g: 8mL

[0034] Preparation of electrospun nanomembranes

[0035]...

Embodiment 2

[0038] In this method, firstly, quercetin and β-cyclodextrin are clathrated to increase the solubility of quercetin without changing the internal structure, and then add zein to DMF to make an electrospinning solution , nanomembranes with high stability, high solubility and special functional properties were prepared by electrospinning.

[0039] Inclusion of Quercetin and β-cyclodextrin

[0040] The molar ratio of quercetin to β-cyclodextrin is 1.2:1, and the inclusion condition is that 1.0 g of quercetin is dissolved in 55 mL of methanol, and then 80 mL is added, stirred at reflux for 2 h at 50° C., and heated for 0.5 h. Remove methanol, cool down naturally, stir for 6 hours, let stand overnight, filter, wash the precipitate with distilled water and methanol, and dry;

[0041] Preparation of electrospinning solution

[0042] The quercetin-β-cyclodextrin inclusion compound, zein, DMF mass volume ratio 5g: 1g: 10mL

[0043] Preparation of electrospun nanomembranes

[0044] ...

Embodiment 3

[0047] In this method, firstly, quercetin and β-cyclodextrin are clathrated to increase the solubility of quercetin without changing the internal structure, and then add zein to DMF to make an electrospinning solution , nanomembranes with high stability, high solubility and special functional properties were prepared by electrospinning.

[0048] Inclusion of Quercetin and β-cyclodextrin

[0049] The molar ratio of quercetin to β-cyclodextrin is 1.1:1, and the clathrate condition is that 1.0 g of quercetin is dissolved in 60 mL of methanol, and then 90 mL is added, stirred at reflux for 4 h at 55° C., and heated for 0.5 h. Remove methanol, cool down naturally, stir for 6 hours, let stand overnight, filter, wash the precipitate with distilled water and methanol, and dry;

[0050] Preparation of electrospinning solution

[0051] The quercetin-β-cyclodextrin inclusion compound, zein, DMF mass volume ratio 4g: 1.2g: 10mL

[0052] Preparation of electrospun nanomembranes

[0053] ...

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Abstract

The invention belongs to the field of food and medicine application, and particularly relates to a quercetin inclusion compound electrospining nanofilm and a preparation method and application thereof. The preparation method includes the following steps that 1, quercetin and beta-cyclodextrin are dissolved in methyl alcohol, a cosolvent is added, reflux stirring is carried out, continuous heating is carried out, reduced-pressure distillation is carried out to remove the solvent, mechanical stirring is carried out, natural cooling and overnight standing are carried out, filtering is carried out, precipitate is washed with distilled water and methyl alcohol in sequence and dried, and a quercetin-beta-cyclodextrin inclusion compound is obtained; 2, the quercetin-beta-cyclodextrin inclusion compound and corn protein are dissolved in DMF, and an electrospinning solution is obtained; 3, the electrospining nanofilm is prepared. The quercetin inclusion compound electrospining nanofilm obtained through the preparation method has both the anti-bacteria function and the slow release function, can serve as an effective treatment means for preventing infection or exacerbation caused when scratches or bruises can not be effectively treated for a long time under extreme conditions in the field, and can also be used for developing preservative and antimicrobial films for food which is extremely likely to decay or needs a high degree of preservation.

Description

technical field [0001] The invention belongs to the application fields of food and medicine, and in particular relates to a quercetin inclusion complex electrospun nano-membrane, its preparation method and application. Background technique [0002] As a natural flavonoid compound with great medicinal potential, quercetin has been widely concerned. Quercetin is a flavonoid compound widely distributed in plants. It is widely found in vegetables, fruits and Chinese herbal medicines, such as onions, grapes, Panax notoginseng and Ginkgo biloba. Quercetin has various pharmacological effects such as anti-oxidation, anti-inflammatory, anti-allergic, anti-bacterial, anti-cancer, anti-HIV, anti-virus, scavenging free radicals in the body, inhibiting the growth and metastasis of malignant tumors, expanding arteries, and improving cerebral circulation. And anti-platelet activating factor, expectorant and cough, reduce capillary permeability and fragility and other biological activities...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): D04H1/4382D04H1/728A61L24/10A61L24/08A61L24/00A61L15/32A61L15/28A61L15/20A61L15/44B65D65/02
CPCD04H1/728A61L15/20A61L15/28A61L15/32A61L15/44A61L24/0015A61L24/08A61L24/108A61L2300/20A61L2300/418B65D65/02D04H1/4382
Inventor 沈汪洋孙威李芳陈轩蔡红燕孙启发
Owner WUHAN POLYTECHNIC UNIVERSITY
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