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Electro-spray ionization mass spectrometry device based on conductive nano-material and method for realizing electro-spray ionization mass spectrometry

An electrospray mass spectrometry and conductive nanotechnology, which is applied in the field of mass spectrometry analysis, can solve the problems of complicated operation, complicated mass spectrometry, interference, etc., and achieve the effects of low cost, simple method and few adjustment parameters.

Inactive Publication Date: 2016-05-11
CHENGDU INST OF BIOLOGY CHINESE ACAD OF S
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, its device still has many adjustable parameters, and it needs to introduce additional auxiliary solution, atomizing gas circuit, etc., which complicates the operation
In addition, the introduction of auxiliary solvents may generate additional matrix interferences that complicate mass spectra

Method used

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  • Electro-spray ionization mass spectrometry device based on conductive nano-material and method for realizing electro-spray ionization mass spectrometry
  • Electro-spray ionization mass spectrometry device based on conductive nano-material and method for realizing electro-spray ionization mass spectrometry
  • Electro-spray ionization mass spectrometry device based on conductive nano-material and method for realizing electro-spray ionization mass spectrometry

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Mass spectrometry was performed on 5 compounds, and the selected sample solutions to be tested were: 2,2'-bipyridine, 5-amino-1,10-phenanthroline, nitrogen-[1,10]phenanthroline-5- base-acrylamide, triphenylphosphine and triphenylphosphine oxide (see Table 1 for details); the solvent used was chloroform, and the concentration of the prepared compound was 40 μg / mL.

[0045] Table 1:

[0046]

[0047]

[0048] The ion source of mass spectrometer is the electrospray mass spectrometry device based on conductive nanomaterial provided by the present invention: electrospray nozzle 5 is carbon nanotube, and its radial dimension is 3mm, and length is 5mm, and thickness is 20 μ m, in electrospray nozzle 5 Cut out a sharp angle of 30° at the front end, the distance d between the tip and the mass spectrometer inlet channel 6 is 3 mm, the sample introduction channel 1 is a quartz capillary with an inner diameter of 100 μm, the electrospray nozzle 5 is a solid structure, and the...

Embodiment 2

[0055] Mass spectrometry was performed on 5 compounds, and the selected sample solutions to be tested were: 2,2'-bipyridine, 5-amino-1,10-phenanthroline, nitrogen-[1,10]phenanthroline-5- base-acrylamide, triphenylphosphine and triphenylphosphine oxide (see Table 1 for details); the solvent used was ethyl acetate, and the concentration of the prepared compound was 40 μg / mL.

[0056] The ion source of the mass spectrometer is the electrospray mass spectrometry device based on conductive nanomaterials in Example 1 of the present invention, and the experimental parameters are the same as those in Example 1 of the present invention, only the solvent is changed.

[0057] The method for realizing electrospray mass spectrometry analysis using the electrospray mass spectrometry device based on conductive nanomaterials comprises the following steps:

[0058] a. The sample solution to be tested flows into the sample introduction channel 1 through a sample pump or a chromatograph. The sam...

Embodiment 3

[0063] Mass spectrometry was performed on 5 compounds, and the selected sample solutions to be tested were: 2,2'-bipyridine, 5-amino-1,10-phenanthroline, nitrogen-[1,10]phenanthroline-5- base-acrylamide, triphenylphosphine and triphenylphosphine oxide (see Table 1 for details); the solvent used was n-hexane, and the concentration of the prepared compound was 40 μg / mL.

[0064] The ion source of the mass spectrometer is the electrospray mass spectrometry device based on conductive nanomaterials in Example 1 of the present invention, and the experimental parameters are the same as those in Example 1 of the present invention, only the solvent is changed.

[0065] The method for realizing electrospray mass spectrometry analysis using the electrospray mass spectrometry device based on conductive nanomaterials comprises the following steps:

[0066] a. The sample solution to be tested flows into the sample introduction channel 1 through a sample pump or a chromatograph. The sample s...

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Abstract

The invention relates to an electro-spray ionization mass spectrometry device based on a conductive nano-material. The device comprises a sample introducing channel and an electro-spray generation base. The electro-spray generation base comprises a mass spectrometry high-voltage power supply and an electro-spray nozzle. The sample introducing channel is contacted with the electro-spray nozzle; the electro-spray nozzle is made of the conductive nano-material; the mass spectrometry high-voltage power supply is connected with the electro-spray nozzle through a high-voltage line; the front end of the electro-spray nozzle is of an acute-angle tip-end structure; and the front end of the electro-spray nozzle faces to a mass spectrometry entryway. The invention also discloses a method for realizing the electro-spray ionization mass spectrometry through the device. The electro-spray ionization mass spectrometry device has the advantages of not only meeting the requirement of mass spectrometry of a compound dissolved in an electro-spray-friendly solvent, but also meeting the requirement of mass spectrometry of compounds dissolved in the electro-spray-friendly solvent and an electro-spray-unfriendly solvent, such as a low polar solvent. The method is simple; the cost is low; adjustable parameters are few, ionization efficiency is high; introduction of extra auxiliary solvents is not need; and matrix interference of the extra solvents does not exist.

Description

technical field [0001] The invention relates to the technical field of mass spectrometry, in particular to an electrospray mass spectrometer based on conductive nanomaterials and a method for realizing electrospray mass spectrometry. Background technique [0002] Electrospray ionization (ESI), since its introduction in the 1970s, has become the most widely used ionization method in the field of mass spectrometry because of its soft ionization characteristics that are not prone to fragmentation. As a common ionization method for atmospheric pressure mass spectrometry, ESI uses a high-voltage electric field to generate charged droplets, and finally sends analyte ions to the mass spectrometer for detection. The ionization process is completed in a polar organic liquid solvent, and this ionization technique is suitable for ionizing compounds with high polarity. However, many compounds, such as natural products contained in volatile oils, pesticide residues in agricultural produ...

Claims

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Application Information

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IPC IPC(8): H01J49/26H01J49/34H01J49/02
CPCH01J49/02H01J49/26H01J49/34
Inventor 周燕夏兵高元吉
Owner CHENGDU INST OF BIOLOGY CHINESE ACAD OF S
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