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High-content sodium alginate nanofiber membrane and electrostatic spinning manufacturing method thereof

A technology of nanofiber membrane and sodium alginate, which is applied in fiber treatment, textile and papermaking, filament/thread forming, etc., and can solve the problems of limiting nanofiber membrane performance, nanofiber membrane reagent residue, and low sodium alginate content , to achieve low cytotoxicity, improve spinning conditions, and simple preparation process

Inactive Publication Date: 2016-05-18
TIANJIN TEDA JINSHAN PACKING MFR
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] In short, there are generally two problems in the above technical scheme and other similar methods for preparing sodium alginate nanofiber membranes: (1) Chemical reagents such as modifiers and strong polar solvents are used in the preparation process, making the prepared nanofibers There are reagent residues on the membrane, so there is a safety risk; (2) The sodium alginate content in the nanofiber membrane prepared by electrospinning without adding chemical reagents and other spinnable polymers is very low, which limits the performance of the nanofiber membrane , restricting its application

Method used

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  • High-content sodium alginate nanofiber membrane and electrostatic spinning manufacturing method thereof
  • High-content sodium alginate nanofiber membrane and electrostatic spinning manufacturing method thereof
  • High-content sodium alginate nanofiber membrane and electrostatic spinning manufacturing method thereof

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Effect test

Embodiment 1

[0021] (1) Preparation of spinning solution: Dissolve a certain amount of sodium alginate in deionized water and stir evenly at room temperature to prepare a sodium alginate solution with a mass fraction of 3wt%. Dissolve a certain amount of polyethylene oxide in deionized water Stir evenly at room temperature to prepare a polyethylene oxide solution with a mass fraction of 3wt%, dissolve a certain amount of polyvinyl alcohol solution in deionized water and stir evenly at 90°C to prepare a polyvinyl alcohol solution with a mass fraction of 8wt%; then Sodium alginate solution, polyethylene oxide solution and polyvinyl alcohol solution were mixed at a mass ratio of 4:4:2, stirred evenly at room temperature to obtain a homogeneous mixed solution, and then TX- 100 Stir evenly at room temperature to obtain an electrospinning solution;

[0022] (2) Preparation of composite nanofiber membrane: The electrospinning solution prepared in step (1) was left to stand at room temperature for...

Embodiment 2

[0025] (1) Preparation of spinning solution: Dissolve a certain amount of sodium alginate in deionized water and stir evenly at room temperature to prepare a sodium alginate solution with a mass fraction of 3wt%. Dissolve a certain amount of polyethylene oxide in deionized water Stir uniformly at room temperature to prepare a polyethylene oxide solution with a mass fraction of 3 wt%, dissolve a certain amount of polyvinyl alcohol solution in deionized water and stir at 90°C to prepare a polyvinyl alcohol solution with a mass fraction of 8 wt%. Then sodium alginate solution, polyethylene oxide solution and polyvinyl alcohol solution are mixed in a mass ratio of 5:4:1, stirred evenly at room temperature to obtain a homogeneous mixed solution, and then added to the homogeneous mixed solution with a mass fraction of 1wt% TX -100 Stir evenly at room temperature to obtain the electrospinning solution;

[0026](2) Preparation of composite nanofiber membrane: The electrospinning solut...

Embodiment 3

[0029] (1) Preparation of spinning solution: Dissolve a certain amount of sodium alginate in deionized water and stir evenly at room temperature to prepare a sodium alginate solution with a mass fraction of 3wt%. Dissolve a certain amount of polyethylene oxide in deionized water Stir uniformly at room temperature to prepare a polyethylene oxide solution with a mass fraction of 3 wt%. Then mix the sodium alginate solution and the polyethylene oxide solution at a mass ratio of 5:5, stir at room temperature to obtain a homogeneous mixed solution, then add TX-100 with a mass fraction of 1.5wt% to the homogeneous mixed solution and stir at room temperature Uniform electrospinning solution;

[0030] (2) Preparation of composite nanofiber membrane: The electrospinning solution prepared in step (1) was left to stand at room temperature for 24 hours to remove air bubbles, and then the spinning solution was injected into the needle tube of the electrospinning device and connected to the...

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Abstract

The invention provides a high-content sodium alginate nanofiber membrane and an electrostatic spinning manufacturing method thereof. The material is formed by sodium alginate or sodium alginate and polyvinyl alcohol, wherein the absolute content of the sodium alginate is 42.5 wt% to 100 wt%, and average diameter of the fiber is 100 nm to 150 nm. A solvent used in a preparation process of an electrostatic spinning solution is deionized water, and a surfactant is TX-100 which is certificated by US Food and Drug Administration. The manufacturing method is simple and feasible, and the high-content sodium alginate nanofiber membrane is not added with any hazardous substance. The manufactured sodium alginate nanofiber membrane is characterized by high content of sodium alginate, thin average diameter, and high porosity. The sodium alginate nanofiber membrane can be applied in the fields of wound dressing and tissue engineering (for example, a support material), etc.

Description

technical field [0001] The invention belongs to the field of polymer materials, and in particular relates to a high-content sodium alginate nanofiber membrane and an electrospinning preparation method thereof. Background technique [0002] Sodium alginate is a natural anionic water-soluble polysaccharide extracted from natural brown algae, composed of two monomers, β-D-mannuronic acid (M) and α-L-guluronic acid (G), Its structure is similar to the polysaccharide components in the extracellular matrix. Sodium alginate has excellent biocompatibility and degradability, has no toxic side effects and does not cause antigenic reactions, and it has been shown to be suitable for various tissue engineering applications, such as skin, cartilage, bone, nerve tissue, etc. [0003] The natural extracellular matrix in human tissue is mainly composed of proteoglycans (glucosaminoglycan (GAG)) and fibrin, both of which have nanostructured components; studies have shown that nanostructured ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): D04H1/728D01D5/00
Inventor 王春红李洪昌李锡伯张桂燕
Owner TIANJIN TEDA JINSHAN PACKING MFR
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