Apixaban sustained-release tablet and preparation method thereof
A technology for apixaban and sustained-release tablets, applied in the field of apixaban sustained-release tablets and their preparation, can solve the problems of inconvenient packaging, transportation, storage, low drug release stability effect, and large gastrointestinal irritation. , to achieve the effect of improving bioavailability, small individual differences, and easy absorption
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[0025] An apixaban sustained-release tablet is characterized in that it is made of the following raw materials: 5 mg of apixaban, 50-95 mg of hypromellose, and 3-20 mg of lubricant.
[0026] The preferred weight ratio of the raw materials is: 5 mg of apixaban, 93 mg of hypromellose, and 5 mg of lubricant.
[0027] The hypromellose can be one or two of the following models: 75hd100cr hypromellose, 75hd4000cr hypromellose, 75hd15000cr hypromellose, 100000cr hypromellose.
[0028] The lubricant is one or both of magnesium stearate, talcum powder and silicon dioxide.
[0029] Its production method includes the following steps:
[0030] Step 1: Preparation of raw materials: according to the above mass ratio, apixaban is pulverized with a pulverizer, and passed through a 100-mesh sieve;
[0031] Step 2: Mixing: Weigh apixaban and hypromellose according to the above mass ratio and mix them in a three-dimensional mixer for 30 minutes to make drug subdivisions and take ...
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