Self-emulsifying soft capsule with peony seed oil and application of self-emulsifying soft capsule to preparing blood fat reducing healthcare products or medicines

A technology for self-emulsifying soft capsules and peony seed oil, applied in the field of medicine, can solve the problems of insignificant drug effect and low bioavailability, and achieve the effects of excellent storage stability, improved bioavailability, and improved blood lipid-lowering effect.

Active Publication Date: 2016-06-01
GUANGZHOU OUHUA PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For example, its bioavailability is low and its efficacy is not significant

Method used

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  • Self-emulsifying soft capsule with peony seed oil and application of self-emulsifying soft capsule to preparing blood fat reducing healthcare products or medicines
  • Self-emulsifying soft capsule with peony seed oil and application of self-emulsifying soft capsule to preparing blood fat reducing healthcare products or medicines
  • Self-emulsifying soft capsule with peony seed oil and application of self-emulsifying soft capsule to preparing blood fat reducing healthcare products or medicines

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] The ingredients are as shown in Table 1:

[0036] Table 1 Composition of peony seed oil self-emulsifying soft capsules

[0037]

[0038] S1. Mix soy lecithin, glycerin and polyethylene glycol-400 as shown in Table 1, stir twice with a shearing machine (8000 rpm), the first time is 5 minutes, and the second time is 2 minutes to disperse Uniform;

[0039]S2. Add warm peony seed oil, stir 3 times for 2 minutes each time to make colostrum, then transfer to a high-pressure homogenizer for homogenization 3 times, filter to form a uniform peony seed oil emulsion concentrate, That is, the self-emulsifying system composition A of peony seed oil;

[0040] S3. Add gelatin into the sol tank, add proportioned 80°C water, add preservative ethylparaben, add opacifier and coloring agent if necessary, seal and heat at the same time, stir until melting and swelling are complete, add glycerin, seal the formulation In the glue tank, turn off the stirring, turn on the vacuum pump, eva...

Embodiment 2

[0044] Composition is as shown in table 2:

[0045] Table 2 Composition of peony seed oil self-emulsifying soft capsules

[0046]

[0047] S1. As shown in Table 2, take peony seed oil, liquid lecithin, and polyoxyethylene fatty acid ester and place them in the same container for ultrasonic stirring and mixing to form a uniform solution that is the self-emulsifying system composition B of peony seed oil;

[0048] S2. Add gelatin to the sol tank, add proportioned 80°C water, add preservative ethylparaben, add opacifier and coloring agent if necessary, seal and heat at the same time, stir until melting and swelling are complete, add glycerin, seal the formulation In the glue tank, turn off the stirring, turn on the vacuum pump, evacuate, and wait for the air bubbles to be exhausted to obtain the soft capsule material liquid. Keep warm at 50-70°C for later use. Take soft capsule material liquid and self-emulsifying system composition B of peony seed oil, put it on a soft caps...

Embodiment 3

[0052] The ingredients are as shown in Table 3:

[0053] Table 3 Composition of peony seed oil self-emulsifying soft capsules

[0054]

[0055] S1. As shown in Table 3, take peony seed oil, liquid lecithin, and glycerin and place them in the same container for ultrasonic stirring and mixing to form a uniform solution that is the self-emulsifying system composition C of peony seed oil;

[0056] S2. Add gelatin to the sol tank, add proportioned 80°C water, add preservative ethylparaben, add opacifier and coloring agent if necessary, seal and heat at the same time, stir until melting and swelling are complete, add glycerin, seal the formulation In the glue tank, turn off the stirring, turn on the vacuum pump, evacuate, and wait for the air bubbles to be exhausted to obtain the soft capsule material liquid. Keep warm at 50-70°C for later use. Take soft capsule material liquid and self-emulsifying system composition C of peony seed oil, put it on a soft capsule machine, prepar...

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Abstract

The invention provides a self-emulsifying soft capsule with peony seed oil and application of the self-emulsifying soft capsule to preparing blood fat reducing healthcare products or medicines. The self-emulsifying soft capsule with the peony seed oil contains self-emulsifying compositions with the peony seed oil. The self-emulsifying compositions with the peony seed oil are effective components and comprise, by weight, 40-70%of medicine components with the peony seed oil, 20-55% of emulsifiers and 5-20% of co-emulsifiers. The self-emulsifying soft capsule and the application have the advantages that the self-emulsifying soft capsule with the peony seed oil is high in dispersibility and excellent in storage stability, active components have self-emulsifying characteristics, accordingly, the bioavailability of the self-emulsifying soft capsule can be greatly improved, and blood fat reducing effects of the peony seed oil and the medicines can be improved.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a peony seed oil self-emulsifying soft capsule and its application in the preparation of blood lipid-lowering health products or medicines. Background technique [0002] Peony seed oil is a hydrophobic golden yellow transparent oil extracted from peony seeds. Peony seeds are the seeds of Paeoniasuffruticosa Andr., a deciduous shrub of the family Ranunculaceae. Peony is a multi-purpose plant that has been used in my country for more than 2,000 years and is widely planted. Peony seed oil is currently produced in my country, and it is a natural vegetable oil resource that has attracted much attention recently. The research on the chemical composition and nutrition and health care function of peony seed oil is currently in-depth. The chemical composition of peony seed oil is mainly composed of fatty acids: it contains a large amount of unsaturated fatty acids (UFA), th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/71A61K9/48A61P3/06
CPCA61K9/4825A61K9/4858A61K9/4866A61K36/71
Inventor 陈惠良李颖陈桂恩陈桂柱陈展权
Owner GUANGZHOU OUHUA PHARMA
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