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Composite peony seed oil self-emulsifying system composition and preparation method thereof

A peony seed oil, self-emulsifying technology, applied in the field of medicine, can solve the problems of unqualified disintegration, leakage of oily components, migration of capsule substances, etc. Effect

Active Publication Date: 2016-06-01
GUANGZHOU OUHUA PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in the existing literature, there is no report about the composition of the peony seed oil self-emulsifying system and its preparation method, and there is no report about the composition of the compound peony seed oil self-emulsifying system and its preparation method. Oil is used as a report on health products, such as patent CN104666458A discloses "a kind of American ginseng soft capsule containing peony seed oil and its preparation method", and the peony seed oil is mixed with medicine to directly compress into a soft capsule containing peony seed oil
However, existing soft capsules containing peony seed oil have the defect of low bioavailability
In addition, making peony seed oil into soft capsules requires overcoming some difficulties, such as unqualified disintegration during storage, material migration and leakage of oily components in the capsule, stability problems such as increased acid value and oxidation value

Method used

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  • Composite peony seed oil self-emulsifying system composition and preparation method thereof
  • Composite peony seed oil self-emulsifying system composition and preparation method thereof
  • Composite peony seed oil self-emulsifying system composition and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] Preparation of compound peony seed oil self-emulsifying system soft capsule

[0053] The composition of the compound peony seed oil self-emulsifying system soft capsule is shown in Table 1.

[0054] Table 1 Composition of compound peony seed oil self-emulsifying system soft capsules

[0055]

[0056] S1. Mix soybean lecithin, glycerin, sorbitol, vitamin E and polyethylene glycol-400 as shown in Table 1, and stir twice with a shearing machine (8000 rpm), for the first time for 5 minutes, and for the second time 2 minutes to make it evenly dispersed;

[0057] S2. Add warm peony seed oil and Ganoderma lucidum spore oil, stir 3 times for 2 minutes each time to make colostrum, then transfer to a high-pressure homogenizer for homogenization 3 times, filter to form a uniform compound peony seed Oil emulsion concentrate, that is, the self-emulsifying system composition A of compound peony seed oil;

[0058] S3. Add gelatin into the sol tank, add proportioned 80°C water, a...

Embodiment 2

[0060] Preparation of Compound Peony Seed Oil Self-emulsifying System Soft Capsules II

[0061] The composition of the compound peony seed oil self-emulsifying system soft capsule is shown in Table 2.

[0062] Table 2 Composition of compound peony seed oil self-emulsifying system soft capsules

[0063]

[0064] S1. Mix soybean lecithin, glycerin, sorbitol, vitamin E and polyethylene glycol-400 as shown in Table 2, and stir twice with a shearing machine (8000 rpm), the first time for 5 minutes, and the second time 2 minutes to make it evenly dispersed;

[0065] S2. Add warm peony seed oil and Ganoderma lucidum spore oil, stir 3 times for 2 minutes each time to make colostrum, then transfer to a high-pressure homogenizer for homogenization 3 times, filter to form a uniform compound peony seed Oil emulsion concentrate, that is, the self-emulsifying system composition B of compound peony seed oil;

[0066] S3. Add gelatin into the sol tank, add proportioned 80°C water, add p...

Embodiment 3

[0068] Preparation of compound peony seed oil self-emulsifying soft capsules

[0069] The composition of the compound peony seed oil self-emulsifying system soft capsule is shown in Table 3.

[0070] Table 3 Composition of compound peony seed oil self-emulsifying system soft capsules

[0071]

[0072] S1. benzaze 30, 1, 2-propanediol, sorbitol, vitamin E and polyoxyethylene fatty acid ester are mixed as shown in table 3, and are stirred twice with a shearing machine (8000 rev / min), the first time 5 Minutes, 2 minutes for the second time to make it evenly dispersed;

[0073] S2. Add warm peony seed oil and Ganoderma lucidum spore oil, stir 3 times for 2 minutes each time to make colostrum, then transfer to a high-pressure homogenizer for homogenization 3 times, filter to form a uniform compound peony seed Oil emulsion concentrate, that is, the self-emulsifying system composition C of compound peony seed oil;

[0074] S3. Add gelatin into the sol tank, add proportioned 80°...

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Abstract

The invention provides a composite peony seed oil self-emulsifying system composition and a preparation method thereof. The self-emulsifying system composition comprises composite peony seed oil, emulsifier and co-emulsifier, can further contain dispersant and / or solid adsorbent and can be prepared into oral formulations like soft capsules, liquid capsules, hard capsules and granules. The self-emulsifying system composition after entering a body can self-microemulsify under action of gastrointestinal liquid to form emulsified liquid, and absorption of the self-emulsifying system composition in a gastrointestinal tract can be promoted, so that bioavailability and efficacy of the composite peony seed oil self-emulsifying system composition are improved. The self-emulsifying system composition is low in cost, high in stability, convenient to store and transport and little in side effect, and compliance of a patient with oral formulation medicine based on the composite peony seed oil self-emulsifying system composition can be improved.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a compound peony seed oil self-emulsifying system composition. Background technique [0002] Peony seed oil is a hydrophobic golden yellow transparent oil extracted from peony seeds. Peony seed oil is currently produced in my country, and it is a natural vegetable oil resource that has attracted much attention recently. The chemical composition of peony seed oil is mainly fatty acids, containing a large amount of unsaturated fatty acids (UFA), the total amount of which is about 80% to 92%, which is significantly higher than that of olive oil, soybean oil and peanut oil known as "liquid gold". vegetable oil. It is particularly noteworthy that the UFA composition in peony seed oil is mainly α-linolenic acid, with a content generally ranging from 32% to 67%, which is much higher than other common vegetable oils and similar to linseed oil. In addition to the obvious a...

Claims

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Application Information

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IPC IPC(8): A61K36/8994A61K36/71A61K9/107A61K9/48A61K9/16A61K47/44A61P37/04A61P35/00
CPCA61K9/107A61K9/1617A61K9/4858A61K36/074A61K36/71A61K36/8994A61K47/44A61K2300/00
Inventor 陈惠良李颖陈桂恩陈桂柱陈展权
Owner GUANGZHOU OUHUA PHARMA
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