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Metabolism marker used for diagnosing and distinguishing coronary atherosclerosis and coronary heart disease

A technology of coronary atherosclerosis and metabolic markers, applied in the field of biochemistry, to achieve the effects of promoting standardization, improving diagnostic convenience, and high sensitivity

Active Publication Date: 2016-06-01
CHINA PHARM UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

No one has used plasma metabolite levels to diagnose coronary atherosclerosis or coronary heart disease

Method used

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  • Metabolism marker used for diagnosing and distinguishing coronary atherosclerosis and coronary heart disease
  • Metabolism marker used for diagnosing and distinguishing coronary atherosclerosis and coronary heart disease
  • Metabolism marker used for diagnosing and distinguishing coronary atherosclerosis and coronary heart disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Example 1: Screening and Characterization of Plasma Differential Metabolites between Patients with Coronary Atherosclerosis or between Patients with Coronary Heart Disease and Healthy People, and Between Patients with Coronary Atherosclerosis and Patients with Coronary Heart Disease

[0031] 1. Objects and methods

[0032] 1. The source of the specimen

[0033] After obtaining the consent of the patients, the peripheral venous blood plasma of 480 patients with coronary atherosclerosis, 867 patients with coronary heart disease and 350 healthy people in Jiangsu Provincial People's Hospital from September 2010 to June 2015 was collected. Confirmed by coronary angiography. The age and sex of healthy people were matched with patients with coronary atherosclerosis and coronary heart disease. All patients with coronary atherosclerosis, coronary heart disease and healthy people have normal heart, lung, liver, kidney and hematopoietic functions.

[0034] The time of blood col...

Embodiment 2

[0058] Example 2: Constructing a ROC curve to compare the ability of 9 plasma differential metabolites to diagnose and distinguish coronary atherosclerosis patients from healthy people, coronary heart disease patients from healthy people, and coronary atherosclerosis patients from coronary heart disease patients

[0059] Receiver operating curve (ROC) method was used for verification, and the ability to diagnose coronary atherosclerosis was judged by the expression levels of differential metabolites in the plasma of patients with coronary atherosclerosis and healthy people; The expression levels of differential metabolites in human plasma can be used to judge its ability to diagnose coronary heart disease; the expression levels of differential metabolites in the plasma of patients with coronary atherosclerosis and coronary heart disease can be used to diagnose and distinguish between coronary atherosclerosis and coronary heart disease. capacity for coronary heart disease. The ...

Embodiment 3

[0081] Example 3: Application in Screening for the Treatment or Relief of Drugs for Coronary Atherosclerosis or Coronary Heart Disease

[0082] Detect the blood plasma before and after drug treatment of patients with coronary atherosclerosis (155 cases) or coronary heart disease (226 cases), the results show that: with the increase of the course of drug treatment, the patient's condition is gradually relieved, the present invention The plasma levels of the 9 metabolic markers provided gradually tended to the levels of healthy people, and there was no significant difference between the plasma levels of healthy people after complete cure (P>0.05). This result is consistent with the detection results of coronary angiography. Therefore, the metabolic markers provided by the present invention can be used to screen drugs for treating or alleviating human coronary atherosclerosis or coronary heart disease.

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Abstract

The invention discloses a metabolism marker used for diagnosing and distinguishing coronary atherosclerosis and coronary heart disease. The metabolism marker comprises one or more of 1-palmityl-sn-glycerin-phosphatidylcholine, 1-octadec n-butane enoyl-sn-glycerin-3-phosphatidylcholine, 1-linoleic acyl-sn-glycerin-3-phosphatidylcholine, 1-stearoyl-sn- glycerin-3-phosphatidylcholine, 1-linoleic acyl-2-hydroxyl-sn- glycerin-3-phosphatidylcholine, 1-linoleic acyl-sn-glycerin-3-phosphatidylcholine, 1-oleoyl-sn-glycerin-3-phosphatidylcholine, hexadecanamide and 1-palm oil acyl-sn-glycerin-3- phosphatidylcholine. The metabolism marker can accurately diagnose the coronary atherosclerosis or the coronary heart disease, can also be used for diagnosing and distinguishing the coronary atherosclerosis and the coronary heart disease, and is high in accuracy, sensitivity and specificity.

Description

technical field [0001] The invention belongs to the field of biochemistry and relates to disease diagnosis markers, in particular to a group of metabolic markers for diagnosing coronary atherosclerosis or coronary heart disease, or for diagnosing and distinguishing coronary atherosclerosis and coronary heart disease. Background technique [0002] Coronary heart disease, also known as ischemic heart disease, involves atherosclerosis in the arteries supplying myocardial blood, that is, coronary atherosclerotic lesions cause vascular lumen narrowing or plaque formation or even rupture and complete blockage, resulting in myocardial ischemia and hypoxia. Or necrosis leads to cardiac ischemic disease, which leads to a series of serious cardiovascular events such as clinical angina pectoris and myocardial infarction. Coronary heart disease is the main killer of human health. It has the characteristics of high incidence rate, high disability rate, high recurrence rate, high mortalit...

Claims

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Application Information

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IPC IPC(8): G01N30/02
CPCG01N30/02G01N2030/025G01N2030/027G01N2800/323G01N2800/324
Inventor 范勇赵艺静齐炼文刘丽伟朱伟李萍陈彦
Owner CHINA PHARM UNIV
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