A kind of water-soluble astaxanthin derivative and preparation method thereof
A technology of astaxanthin and derivatives, applied in food science, animal feed, additional food elements, etc., to achieve the effect of improving the application range, simple process, and expanding the application range
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Image
Examples
preparation example Construction
[0024] The astaxanthin succinate diester-PEG derivative of the present invention and its preparation method, the specific steps are as follows:
[0025] Raw material: use astaxanthin powder or astaxanthin solution dissolved in a specific organic solvent as the raw material, the structural formula is as formula (III);
[0026]
[0027] 1) Add succinic anhydride to the raw materials, the molar ratio of astaxanthin to succinic anhydride is 1:10~1:20, heating, temperature control at 30℃~100℃, reaction time 0.5h~20h; add after reaction The water was stirred and the precipitate was collected by centrifugation to obtain the hydroxyl esterified product (II). Since succinic anhydride is a cyclic acid anhydride, its carboxyl groups are connected, so its reaction product with hydroxyl exists in the form of dibasic acid monoester and introduces another carboxylic acid group. After the reaction, water was added to the reaction system to precipitate the produced astaxanthin succinic acid dieste...
Embodiment 1
[0031] Example 1 Preparation of astaxanthin succinate diester-PEG400 derivative
[0032] Weigh 1g of astaxanthin powder, add 3 times the molar amount of succinic anhydride, heat to 50°C, and react for 2h; after the reaction is completed, slowly add water to the reaction system and stir. When precipitation occurs, centrifuge to collect the precipitate to obtain the hydroxy ester The resulting hydroxyl esterified product, dichloromethane, was added 15 times the molar amount of polyethylene glycol 500, and reacted for 2 hours at 50°C. After the reaction was completed, the dichloromethane in the system was removed, and the precipitate was collected to obtain shrimp Penicillin succinic acid diester—PEG400 derivative, the obtained derivative was separated and characterized by TLC, and the results are as follows figure 2 As shown in 2, will figure 2 Scraper purification and saponification of the reaction components in the saponification process, using 0.05mol / L KOH / methanol solution to...
Embodiment 2
[0033] Example 2 Preparation of astaxanthin succinate diester-PEG1000 derivative
[0034] Weigh 10 mL of a dioxane solution containing 1 g of astaxanthin, add 4 times the molar amount of succinic anhydride, heat to 60°C, and react for 1.5 hours; after the reaction is completed, slowly add water to the reaction system and stir until precipitation occurs. The precipitate was collected by centrifugation to obtain the hydroxyl esterification product; the obtained hydroxyl esterification product was dissolved in acetone solution, and 10 times the molar amount of polyethylene glycol 1000 was added. The reaction was carried out at 65°C for 1 hour. After the reaction was completed, the system was removed Acetone solution, collect the precipitate to obtain the astaxanthin succinate diester—PEG1000 derivative. The obtained derivative is separated and characterized by TLC such as TLC figure 2 As shown in 3, the reaction components in 3 are subjected to scraper purification and saponificatio...
PUM
| Property | Measurement | Unit |
|---|---|---|
| degree of polymerization | aaaaa | aaaaa |
Abstract
Description
Claims
Application Information
Login to View More