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Method for preparing smell-reduced bezoar detoxicating capsules

A technology of prescription and rhubarb, applied in the direction of capsule delivery, pharmaceutical formula, medical preparations containing active ingredients, etc., to achieve the effect of good stability, excellent release, and high content of active ingredients

Active Publication Date: 2016-06-15
广东隆信制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

On the basis of maintaining the original curative effect, the safety problem of arsenic poisoning caused by realgar in Niuhuangjiedu Tablets was solved

Method used

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  • Method for preparing smell-reduced bezoar detoxicating capsules
  • Method for preparing smell-reduced bezoar detoxicating capsules
  • Method for preparing smell-reduced bezoar detoxicating capsules

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Embodiment 1: vacuum concentration process test

[0038] The raw materials of gypsum, bellflower, licorice and baicalin are purified. According to the prescription ratio, 160g of purified gypsum, 80g of platycodon grandiflorum, 40g of licorice, and 120g of baicalin were accurately weighed respectively, and placed in a round bottom flask. According to the ratio of material to liquid 1:10, 4L of purified water was added, and the temperature was kept at 100°C. After decocting in a boiling water bath for 2 hours, filter and collect the filtrate. Add 4L of purified water to the filter residue at a material-to-liquid ratio of 1:10, decoct in a microboiling water bath at a constant temperature of 100°C for 2 hours, filter, and combine the filtrates after two extractions to obtain a mixed extract. The content of baicalin in the above extract was detected as 1.112 mg / mL by referring to the method for the determination of content under the item of Scutellaria baicalensis in medi...

Embodiment 2

[0055] Embodiment 2: vacuum drying process test

[0056] The raw materials of gypsum, bellflower, licorice and baicalin are purified. According to the prescription ratio, 160g of purified gypsum, 80g of platycodon grandiflorum, 40g of licorice, and 120g of baicalin were accurately weighed respectively, and placed in a round bottom flask. According to the ratio of material to liquid 1:10, 4L of purified water was added, and the temperature was kept at 100°C. After decocting in a boiling water bath for 2 hours, filter and collect the filtrate. Add 4L of purified water to the filter residue according to the ratio of material to liquid 1:10, decoct in a constant temperature 100°C micro-boiling water bath for 2 hours, filter, and combine the filtrates after two extractions. The filtrate is concentrated under reduced pressure under vacuum, the concentration temperature is set at 80°C, the vacuum degree is -0.07MPa, and concentrated to an extract with a relative density of about 1.0...

Embodiment 3

[0067] Embodiment 3: the preparation of reducing flavor Niuhuangjiedu capsule

[0068] The composition of the prescription is as follows: (1000 capsules)

[0069]

[0070] The capsule preparation method is as follows:

[0071] (1) Preparation of Rhubarb and Borneolum medicinal powder:

[0072] Rhubarb medicinal materials are cleaned, cut and dried. The dried medicinal material is pulverized and passed through an 80-mesh sieve to obtain rhubarb medicinal material powder, which is set aside. Take the crushed borneol and pass through an 80-mesh sieve to obtain the borneol medicinal powder, which is set aside.

[0073] (2) Preparation of dry cream powder:

[0074] The raw materials of gypsum, bellflower, licorice and baicalin are purified. Precisely weigh 200g of gypsum, 100g of Platycodon grandiflorum, 50g of licorice, and 150g of Scutellaria baicalensis, and put them into the extraction tank. Add water for extraction twice: add 8 times water for the first time, boil at ...

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Abstract

The invention relates to the field of pharmaceutical preparations and particularly relates to a method for preparing smell-reduced bezoar detoxicating capsules. The method for preparing smell-reduced bezoar detoxicating capsules comprises the following steps: pretreating the raw materials; fetching the cleaned gypsum, platycodon grandiflorum, liquorice and scutellaria baicalensis of formula dosage, adding water and decocting and then collecting the filtrate; performing vacuum concentration to obtain an extract; performing vacuum drying and grinding into dry paste powder; uniformly mixing the dry paste powder with the ground rheum officinale, calculus bovis factitius powder and dextrin of formula dosage; performing wet granulation and drying; uniformly mixing with the ground borneol of formula dosage; and filling the capsules. By adopting the preparation method provided by the invention, up to 320000 capsules can be produced by each batch in enlarged production conditions, and industrial mass production is easy to implement. The prepared smell-reduced bezoar detoxicating capsules have the advantages of conformity to quality standard, high content of active ingredients, good stability, quick disintegration, easiness in absorption and high release rate.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to a method for preparing flavor-reduced Niuhuang Jiedu capsules. Background technique [0002] Niuhuang Jiedu Tablet is a common heat-clearing and detoxifying medicine at home, and it is also a traditional Chinese patent medicine. It is composed of bezoar, realgar, gypsum, rhubarb, scutellaria, bellflower, borneol, and licorice. It has the effect of clearing away heat and detoxifying. , swollen and painful gums, sore tongue, red eyes and swollen and painful embolisms. Recent studies have found that long-term use of Niuhuang Jiedu Tablets has toxic side effects on the nervous system, digestive system, urinary system, blood, breathing, and skin. The main toxic substance in Niuhuang Jiedu Tablets is realgar, and its content is quite large. Its main component is arsenic trisulfide, also known as arsenic. Arsenic is not only toxic to the liver, kidneys, blood system, nervous...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/48A61K36/708A61P11/04A61P29/00A61P1/02A61K31/045A61K35/413A61K33/06
CPCA61K9/4866A61K31/045A61K33/06A61K35/413A61K36/346A61K36/484A61K36/539A61K36/708A61K2236/51A61K2300/00
Inventor 贾放许雅文陈华兆谢绍礼刘海芹
Owner 广东隆信制药有限公司
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