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New use of Qing'e pill in depression and anxiety prevention

A Qing'e Pill, an anti-depressant technology, applied in the direction of medical preparations containing active ingredients, pill delivery, plant raw materials, etc., to achieve behavioral improvement, treatment and improvement of depression and anxiety diseases

Inactive Publication Date: 2016-06-22
SHANGHAI UNIV OF T C M
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The present invention relates to the antidepressant and anti-anxiety effects and efficacy of Qing'e Pills, and no relevant reports have been seen yet

Method used

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  • New use of Qing'e pill in depression and anxiety prevention
  • New use of Qing'e pill in depression and anxiety prevention
  • New use of Qing'e pill in depression and anxiety prevention

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0015] Experimental Example 1 Improvement of the rat olfactory bulb damage model caused by the Qing'e pill of the present invention

[0016] (1) Experimental drugs and instruments

[0017] Drug: Qing'e Pill, batch number 20120509, produced by Shanghai Leiyunshang Pharmaceutical Co., Ltd. Fluoxetine hydrochloride (also known as Prozac), batch number 2076A, produced by Fatheon France. Venlafaxine, lot number 1308025, manufactured by Pfizer Iret and Pharmaceuticals. Isoflurane, r-aminobutyric acid (GABA), glutamic acid (Glu), serotonin (5-HT) 5-HT, epinephrine (Epi), dopamine (DA) DA, norepinephrine (NE ) NE, 5-hydroxyindoleacetic acid (5-HIAA), 3,4-dihydroxybenzylamine (internal standard) The above are all products of Sigma Company. Instruments: "Dr. Rat" Animal Behavior Analysis: Elevated Plus Maze (RD1108-EPM-M), Forced Swimming Experiment Analysis System Model (RD1119-FST-M), Tail Suspension Experiment Analysis System Model (RD1118-TST-M), Open Field Analysis System (RD11...

specific Embodiment 2

[0087] The use of Qing'e Pill in the preparation of an antidepressant and anti-anxiety composition is characterized in that: the Qing'e formula consists of 480 grams of Eucommia (fried with salt), 240 grams of psoralen (fried with salt), 150 grams of walnut kernels (fried with salt), Composed of 120 grams of garlic.

[0088] For the above four flavors, steam the garlic, dry it, stir-fry Eucommia ulmoides with salt, stir-fry psoralen with salt, pulverize it into fine powder, sieve, smash the fried walnut kernels, grind with the above powder, sieve and mix well. For every 100g of powder, use 30g of refined honey to add an appropriate amount of water to make pills, and dry them to make water honeydew pills; or add 70g of refined honey to make large honeydew pills.

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Abstract

The invention discloses a use of a Qing'e pill in the preparation of depression and anxiety prevention compositions. The Qing'e pill can be orally taken to increase the total mine field activity path of experiment animals, shortens the tail suspension immobility time, prolongs the entrance elevated plus maze open arm time, shortens the forced swimming immobility time, and has a good depression prevention effect. The Qing'e pill can increase the content of 5-hydroxytryptamine (5-HT), norepinephrine (NE) and gamma-aminobutyric acid (gamma-GABA) in a hippocampal region and reduce the content of glutamic acid (Glu). The gamma-GABA content increase and Glu content reduction effects of the Qing'e pill show that the Qing'e pill can regulate neurotransmitter Glu and gamma-GABA metabolism effects of a central nervous system neurotransmitter, reduce the ratio of Glu / gamma-GABA, weakens the transmission of the GABA neurotransmitter and regulate the responsiveness of a receptor catecholamine, so the Qing'e pill plays a role in depression and anxiety prevention. The Qing'e pill increases the level of 5-HT in the central nervous system and plays a role in the depression and anxiety prevention through inhibiting the activity of monoamine oxidase.

Description

technical field [0001] The invention relates to a new use of Qing'e Pill, in particular to a new use of Qing'e Pill for treating or relieving depression and anxiety. technical background [0002] Depression is characterized by persistent low mood and cognitive dysfunction as the main clinical features, including agitation, anhedonia, sleep disturbance, guilt, and repeated suicidal thoughts. There are 340 million people with depression worldwide. The current incidence of depression in China is about 4%. According to the statistics of the World Health Organization, depression has become the fourth largest disease in the world, and it is estimated that by 2020, it may become the second largest disease after coronary heart disease. Depression not only brings mental loss to the patient, but also causes a heavy economic burden to the patient. The total economic burden caused by depression in China reached 62.2 billion yuan, and the annual economic loss caused by depression in t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8962A61K9/20A61P25/24A61P25/22
Inventor 王峥涛胡芳弟张紫佳吴晓俊陈文霞
Owner SHANGHAI UNIV OF T C M
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