Tetrandrine liquid crystal nanoparticle ophthalmic preparation and preparation method thereof

Abstract

The invention discloses a tetrandrine liquid crystal nanoparticle preparation for eyes and a preparation method thereof. The method includes the steps of firstly, adding lipid material, stabilizer and tetrandrine to solvent absolute ethyl alcohol to be heated and dissolved, and conducting decompression rotary steaming to thoroughly remove ethyl alcohol to obtain a uniform oil phase; secondly, adding penetration enhancer and positive ion material to distilled water to be stirred and completely dissolved to obtain a water phase; thirdly, adding the water phase to the oil phase to be shorn, dispersed and cooled to the room temperature to obtain an initial emulsion; fourthly, conducting ultrasound treatment on the initial emulsion to obtain the tetrandrine liquid crystal nanoparticle preparation for eyes. The preparation has huge film surface area, strong medicine carrying capacity, good biological compatibility, high biological adhesiveness and high long-term stability, the number of dosage times can be decreased, and the dependence of patients on medicine is improved. The preparation has the effects on packaging and protecting medicine, increasing dissolvability, improving stability and promoting medicine absorption.

Description

technical field [0001] The invention relates to the field of medicine, in particular to an ophthalmic preparation of tetrandrine liquid crystal nanoparticles and a preparation method thereof. Background technique [0002] Cataract is the clouding of the lens in the eye, from transparent to opaque, which prevents light from entering the eye and affects vision. The initial turbidity has little effect on vision, and then gradually aggravates, significantly affecting vision and even blindness. Cataract is the leading cause of blindness in the world. There are about 20 million people in the world who are blind due to cataract, and another 100 million cataract patients need surgery to restore vision. In most African and Asian countries, cataract accounts for at least half of the blind. Modern pharmacological studies have shown that tetrandrine is a natural non-selective calcium ion channel blocker, which has strong anti-inflammatory, anti-oxidation, anti-fibrosis, lower intraocu...

AI Technical Summary

Problems solved by technology

[0003] With the development of biopharmaceuticals and the continuous deepening of eye pharmacokinetics research, a large number of research results have shown that traditional ophthalmic preparations such as eye drops, eye dressings, eye washes, eye ointments, etc., have a large loss of drug dose. , poor visual acuity, low bioavailability, etc.

Especially for eye diseases that require long-term treatment, it is difficult to achieve long-term effect even if it is used repeatedly, and the use of high-concentration drugs may also cause eye irritation and systemic toxicity.

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