Laminarin and extraction and separation method thereof

A technology of kelp polysaccharide and separation method, which is applied in the directions of pharmaceutical formulations, organic active ingredients, medical preparations containing active ingredients, etc., can solve problems such as unseen and rare single polysaccharide components, and achieve the effect of uniform molecular weight distribution
CN105777930AInactive Publication Date: 2016-07-20FUJIAN HEALTH COLLEGE
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
FUJIAN HEALTH COLLEGE
Publication Date
2016-07-20
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention provides laminarin and an extraction and separation method thereof. The method comprises the following steps: extracting a laminarin crude extract having a yield of 3.6 percent, which is superior to that of a traditional water extraction method, by adopting a high-temperature high-pressure water extraction method; performing two-step separation by DEAE-anion exchange chromatography and Sephacryl S-300 gel chromatography to obtain a kelp purified polysaccharide PS-3-1 having a molecular weight of 132 KDa. The prepared kelp purified polysaccharide has free radical scavenging activity, has a scavenging rate for hydroxyl radicals and superoxide anion being over 70 percent, and can be developed into a free radical scavenging drug. Furthermore, the purified polysaccharide has a reproduction inhibiting activity on vascular smooth muscle cells, has a reproduction inhibition rate of over 75 percent, and can be used for preparing a vascular smooth muscle cell reproduction inhibitor medicine.
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Description

technical field

[0001] The invention relates to the field of extracting active ingredients from seaweed, in particular to a laminarin polysaccharide and an extraction and separation method thereof. Background technique

[0002] kelp( Laminaria japonica ) is distributed in the eastern coastal area of ​​my country and is an economical seaweed with the same source of medicine and food. The medicinal use of kelp has a long history, and its medicinal effects are recorded in many classic pharmacopoeias handed down from generation to generation. Polysaccharide is one of the main active components of kelp. Modern pharmaceutical research results show that kelp polysaccharide has biopharmacological activities such as lowering blood fat, anticoagulation, anti-atherosclerosis, and anti-oxidation. It is one of the hot spots in the research of active components of kelp.

[0003] Hot water extraction is a commonly used method for extracting active polysaccharides from kelp, which has the...

Claims

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