Preparation of 11β-hydroxy-1,4-diene-3,20-dione steroids by joint fermentation of Absidia and Arthrobacter

A combined fermentation and compound technology, applied in fermentation, microbial-based methods, microorganisms, etc., can solve difficult problems such as large enzyme activity
CN105779555BActive Publication Date: 2021-02-02TIANJIN JINYAO GRP
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
TIANJIN JINYAO GRP
Publication Date
2021-02-02

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Abstract

The present invention uses 4-ene-3,20-diketone steroid compound as starting material, and utilizes Agsidiaceae and Arthrobacter to jointly ferment one-step preparation of 11βhydroxy-1,4-diene-3,20-diketone steroid compound.
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Description

technical field

[0001] The invention relates to a production method of steroidal drugs, in particular to one-step preparation of 11β-hydroxyl-1,4-diene-3,20-dione steroidal compounds by joint fermentation of Absidia and Arthrobacter. Background technique

[0002] Steroid drugs are an important class of drugs, with anti-inflammatory, anti-immune, contraceptive, anti-cancer, endocrine regulation and other functions, widely used in rheumatism, cardiovascular disease, collagen disease, lymphatic leukemia, human organ transplantation, Treatment of bacterial encephalitis, skin diseases, endocrine disorders, senile diseases, hormone-dependent tumors and other diseases.

[0003] In the production of steroid hormone drugs, multiple groups of the steroid nucleus need to be modified by chemical methods and microorganisms, among which C 11 β hydroxylation and C 1,2 The introduction of double bonds by dehydrogenation is an important steroid transformation reaction, which is of great si...

Claims

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