Nor solid-phase logic gate based on gold nanocluster-polyelectrolyte complex

Abstract

The invention discloses an NOR solid-phase logic gate based on a gold nanocluster-polyelectrolyte compound. On the basis that Fe<2+> and Fe<3+> can induce fluorescence of bovine serum albumin-3-mercaptopropionic acid-gold nanocluster-polyelectrolyte solid-phase compound to be quenched under the condition of coexistence of an acetate buffer solution with the pH being 4.6, an NOR type solid-phase logic gate system is built by using the Fe<2+> and the Fe<3+> as input signals and using the gold nanocluster-polyelectrolyte compound as a signal converter. The logic gate system has the advantages that the operation is simple and convenient (any modification and marking processes are not needed); the transplanting performance is good; the relocatability is realized; the signal reading diversification is realized, and the like. Good application prospects are realized in the fields of clinic diagnosis, chemical sensing, environment monitoring and the like.

Description

technical field [0001] The invention relates to a NOR solid-phase logic gate based on BSA / 3-MPA-gold nano cluster-polyelectrolyte complex and a construction method thereof, belonging to the field of nanotechnology. Background technique [0002] In the past few decades, chemical Boolean logic gates have attracted extensive attention and have been applied in many fields such as clinical diagnosis, chemical sensing, and environmental monitoring. At present, different types of logic gates, such as AND, OR, IMPLICATION, NAND, NOR, and INHIBIT, can be constructed by using different materials (such as nucleic acids, enzymes, organic molecules, and nanomaterials). However, most of the logic operation systems have the following disadvantages: (1) involve complex modification or labeling process, and the cost is high; (2) they are not resettable; (3) they are poor in portability and difficult to attach to solid surfaces; (4) ) cannot process multiple input signals at the same time an...

AI Technical Summary

Problems solved by technology

However, most of the logic operation systems have the following disadvantages: (1) involve complex modification or labeling process, and the cost is high; (2) they are not resettable; (3) they are poor in portability and difficult to attach to solid surfaces; (4) ) cannot handle multiple input signals at the same time and the integration between logic gates is very difficult

Although many fluorescent dyes have been reported to perform logic operations, the problems of high cost, poor photostability, prone to autoxidation, and high toxicity limit their further applications.

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