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Ciprofloxacin medicine composition and application thereof to biological medicine

A technology of ciprofloxacin and its composition, which is applied in the field of pharmaceutical composition and its application in biomedicine, can solve the problems that have not yet been reported on the correlation of ciprofloxacin with diabetic cardiomyopathy, and achieve the effect of improving the effect

Inactive Publication Date: 2016-07-27
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] So far, there is no report on the correlation between ciprofloxacin and its pharmaceutical composition and diabetic cardiomyopathy

Method used

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  • Ciprofloxacin medicine composition and application thereof to biological medicine
  • Ciprofloxacin medicine composition and application thereof to biological medicine
  • Ciprofloxacin medicine composition and application thereof to biological medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Example 1: Compound (I) Separation Preparation and Structure Confirmation

[0022] Sources of reagents: ethanol, petroleum ether, ethyl acetate, n-butanol, and dichloromethane were of analytical grade, purchased from Shanghai Lingfeng Chemical Reagent Co., Ltd. Methanol, of analytical grade, were purchased from Jiangsu Hanbang Chemical Reagent Co., Ltd.

[0023] Separation method: (a) Grind the dried rhizome (2kg) of Rhizoma Chuanxiong, extract with 65% ethanol under heat reflux (20L×3 times), combine the extracts, concentrate until there is no alcohol smell (4L), and then use petroleum ether (4L× 3 times), ethyl acetate (4L × 3 times) and water-saturated n-butanol (4L × 3 times) were extracted to obtain petroleum ether extract, ethyl acetate extract and n-butanol extract respectively; (b) step (a) The n-butanol extract was removed with AB-8 macroporous resin, first eluted with 10% ethanol for 12 column volumes, then with 70% ethanol for 15 column volumes, and collected...

Embodiment 2

[0027] Embodiment 2: pharmacological action

[0028] 1. Materials and methods

[0029] 1.1 Animals

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Abstract

The invention discloses a ciprofloxacin medicine composition and application thereof to biological medicine. The ciprofloxacin medicine composition provided by the invention contains ciprofloxacin and a natural product compound (I), wherein the natural product compound (I) is obtained through being separated from dry rhizomes of ligusticum wallichii, and has a novel structure; ciprofloxacin and the compound (I) have a protection effect on the heart muscle of a rat model with diabetes B cardiomyopathy; after the combined use of the ciprofloxacin and the compound (I), the protection effect is better; the medicine can be developed into medicine for treating diabetes cardiomyopathy. Compared with the prior art, the ciprofloxacin medicine composition has prominent practical characteristics and an obvious progress.

Description

technical field [0001] The invention belongs to the field of biomedicine and relates to a new application of ciprofloxacin, in particular to a pharmaceutical composition of ciprofloxacin and its application in biomedicine. Background technique [0002] Ciprofloxacin is a synthetic third-generation quinolone antibacterial drug with broad-spectrum antibacterial activity and good bactericidal effect. The antibacterial activity against almost all bacteria is 2 to 4 times stronger than that of norfloxacin and enoxacin. Enterobacter, Pseudomonas aeruginosa, Haemophilus influenzae, Neisseria gonorrhoeae, Streptococcus, Legionella, Staphylococcus aureus have antibacterial effect. [0003] Diabetic cardiomyopathy (diabetic cardiomyopathy, DC) is a type of specific disease of diabetic heart disease (diabetic heart disease, DHD), closely related to the high incidence of heart failure and high mortality in diabetic patients. The onset of DC is hidden, and the early clinical symptoms ar...

Claims

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Application Information

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IPC IPC(8): A61K31/496A61K31/365A61P3/10A61P9/00C07D493/04
CPCA61K31/496A61K31/365A61K36/236C07D493/04
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