Use of Shenqi Jiangtang Granules in the Preparation of Drugs for Diabetic Heart Disease

A technology of Shenqi Jiangtang granules and diabetic heart disease, which is applied in the field of medicinal use of Shenqi Jiangtang granules in the preparation of medicines for preventing or treating diabetic heart disease, and can solve the problem of biological activity or clinical application of diabetic heart disease. Research and other issues, to achieve the effect of significant clinical efficacy and broad application prospects

Active Publication Date: 2017-10-24
LUNAN PHARMA GROUP CORPORATION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] So far, there is no research on the biological activity or clinical application of Shenqi Jiangtang Granules in the treatment of diabetic heart disease

Method used

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  • Use of Shenqi Jiangtang Granules in the Preparation of Drugs for Diabetic Heart Disease
  • Use of Shenqi Jiangtang Granules in the Preparation of Drugs for Diabetic Heart Disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Example 1 Effect of Shenqi Jiangtang Granules on Rat Model of Myocardial Infarction

[0016] The pathophysiological changes and abnormalities of myocardial morphology induced by isoproterenol (ISO) are similar to those of human myocardial infarction. Therefore, isoproterenol-induced myocardial infarction is widely used to study pathophysiological disorders and morphological abnormalities caused by myocardial infarction diseases, so as to evaluate the effect of drugs. The activity of LDH and CK-MB in plasma indirectly reflects the integrity of myocardial cell membrane and changes in the degree of myocardial injury. Leakage leads to elevated levels of LDH and CK-MB in plasma.

[0017] 1 Materials and methods

[0018] 1.1 Experimental animals

[0019] 50 healthy male SD rats, weighing 180g-220g, SPF grade.

[0020] 1.2 Preparation of model

[0021] Rats were intraperitoneally injected with ISO 15mg / kg for 2 consecutive days to create an animal model of myocardial isch...

Embodiment 2

[0033]Example 2 Effect of Shenqi Jiangtang Granules on Myocardial Infarction Model in Diabetic Rats

[0034] 1 Materials and methods

[0035] 1.1 Experimental animals

[0036] 50 male GK rats, weighing 180g-220g; 10 male Wistar rats, SPF grade.

[0037] 1.2 Preparation of model

[0038] Except the Wistar rats in the normal group were fed with common feed, the successful GK rats of diabetes (DM) model were fed with basal feed for 2 weeks, and then fed with high-fat feed for 8 weeks (the high-fat and high-calorie feed consisted of basal feed, refined Lard, cholesterol powder, and sodium cholate powder are mixed in proportions of 87.5%, 10%, 2%, and 0.5%) to replicate the type 2 diabetes model. The successful type 2 diabetes model rats were taken, and after 60 consecutive days, isoproterenol was subcutaneously injected to cause acute myocardial infarction in the rats, and the rat model of diabetic myocardial infarction was replicated.

[0039] 1.3 Animal administration method...

Embodiment 3

[0050] Example 3 Clinical Observation Data of Shenqi Jiangtang Granules in Treating Diabetic Heart Disease

[0051] 1.1 Clinical data: A total of 60 patients with diabetic heart disease were observed, including 30 male patients and 30 female patients. Aged 51-70 years old, average age 58.5 years old.

[0052] 1.2 The diagnostic criteria are:

[0053] (1) There is conclusive evidence of diabetes.

[0054] (2) The ST segment of the electrocardiogram is horizontal or downward sloping ≥ 0.05mV, the T wave is flat, biphasic or inverted.

[0055] (3) Angina pectoris, myocardial infarction or heart failure occurred in the medical history.

[0056] (4) Severe arrhythmia (excluding sinus tachycardia, mild sinus bradycardia, sinus arrhythmia, low voltage and incomplete right bundle branch block).

[0057] (5) X-rays, electrocardiograms, echocardiograms, and vector cardiograms suggest that the heart is enlarged.

[0058] (6) Cardiac mechanical graph (multi-conductor physiological re...

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PUM

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Abstract

The invention relates to application of ginseng and milkvetch root blood sugar reducing particles to preparation of medicine for preventing or treating diabetes type heart diseases and belongs to the field of medicine. The ginseng and milkvetch root blood sugar reducing particles can remarkably reduce the activity of myocardial infarction model rat plasma LDH and CK-MB. The animal experiment shows that the ginseng and milkvetch root blood sugar reducing particles have a remarkable treatment effect on diabetes myocardial infarction. It is shown that a remarkable treatment effect is achieved for the diabetes type heart diseases, side effects are low, and wide medical application prospects are achieved in the clinical application process.

Description

technical field [0001] The invention belongs to the field of medicine, and relates to the medical use of Shenqi Jiangtang granule, in particular to the medical use of Shenqi Jiangtang granule in preparing medicines for preventing or treating diabetic heart disease. Background technique [0002] Diabetes mellitus (DM) is a common endocrine and metabolic disease characterized by chronically elevated blood glucose levels due to absolute or relative insulin secretion insufficiency. In recent years, the incidence and prevalence of DM have been increasing year by year worldwide, and it has become a worldwide health issue that seriously threatens human health and quality of life. DM is not only manifested as long-term chronic elevated blood sugar, but also accompanied by various complications. Among them, cardiovascular complications have become the complications with the highest morbidity and mortality rates and the greatest harm among DM complications. [0003] Diabetic heart d...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8968A61K9/16A61P3/10A61P9/00A61P9/10A61K31/704
CPCA61K9/16A61K31/704A61K36/076A61K36/258A61K36/428A61K36/481A61K36/57A61K36/73A61K36/79A61K36/804A61K36/815A61K36/884A61K36/8945A61K36/8968A61K2300/00
Inventor 张则平张贵民李冰冰
Owner LUNAN PHARMA GROUP CORPORATION
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