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Microfluid self-driven paper base micro-fluidic chip and preparation method and application thereof

A microfluidic chip, self-driven technology, applied in chemical instruments and methods, laboratory containers, analysis by making materials undergo chemical reactions, etc., can solve the problem of low processing precision and cannot meet the requirements of complex microfluidic systems and other problems to achieve the effect of simplifying auxiliary equipment and solving the lack of precision

Active Publication Date: 2016-08-10
ZHEJIANG UNIV OF TECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Aiming at the problem that the current paper-based microfluidic control chip cannot meet the complex microfluidic control system and has low processing precision, the present invention proposes a microfluidic self-driven paper-based chip with high processing precision and can meet the complex microfluidic control system Microfluidic chip, preparation method and application thereof

Method used

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  • Microfluid self-driven paper base micro-fluidic chip and preparation method and application thereof

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Embodiment 1

[0031] Embodiment 1 The preparation method of the microfluidic self-driven paper-based microfluidic chip described in the present invention comprises the following steps:

[0032] 1) Preparation of superhydrophobic titanium dioxide coating solution: mix 0.1g titanium dioxide powder with 10mL absolute ethanol, and then ultrasonicate at 100Hz for 30min to form a 0.01g / mL titanium dioxide suspension, then add 0.2mL octadecyltrimethoxy Silane, continue to ultrasonically mix under the condition of 100Hz, and then react at room temperature for 12h to obtain a superhydrophobic titanium dioxide coating solution; the volume ratio of the octadecyltrimethoxysilane to the titanium dioxide suspension is 0.02:1;

[0033] 2) Preparation of superhydrophobic filter paper: Soak a filter paper sheet with a diameter of 9 cm in the above-mentioned superhydrophobic titanium dioxide coating solution for 5 minutes, take it out, and dry it naturally at room temperature; repeat the operation 3 times to ...

Embodiment 2

[0036] Example 2 The microfluidic chip prepared according to the preparation method described in Example 1, comprising a filter paper 1, a hydrophilic-hydrophobic layer 2 coated on the surface of the filter paper, and the hydrophilic-hydrophobic layer 2 is provided with at least one gradient moistening layer. The hydrophilic flow channel 21 on the wet surface; one end of the hydrophilic flow channel 21 is used as the sample loading area 22, and the other end is used as the detection area 23; the hydrophilic flow channel 21 is divided into multiple areas from the sample loading area 22 to the detection area 23 , a number of hydrophobic patterns 24 are evenly distributed in each region, and the corresponding position of each hydrophobic pattern 24 corresponding to the substrate is a superhydrophobic region, and the region outside the hydrophobic pattern is a superhydrophilic region; along the direction from the sample application region to the detection region, the The number of ...

Embodiment 3

[0039] Embodiment 3 According to the application of the microfluidic chip described in embodiment 2 in the detection of hydrogen peroxide, the described application method is carried out according to the following steps:

[0040] (1) will 8x10 -4 M, 4x10 -4 M, 1x10 -4 M, 0.1x10 -4 Four different concentrations of potassium iodide are loaded in the detection area, and 3% hydrogen peroxide is dropped into the sampling area of ​​the tested sample. The hydrogen peroxide droplets can quickly and automatically pass through the flow channel and reach the detected area. The potassium iodide in the detection area is oxidized by hydrogen peroxide. Color change; hydrogen peroxide droplets can quickly and automatically pass through the flow channel and reach the detected area. Potassium iodide is reduced to colored iodine by hydrogen peroxide. Different concentrations of potassium iodide show different color intensities after being reduced;

[0041] (2) Color grayscale processing proce...

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Abstract

The invention discloses a microfluid self-driven paper base micro-fluidic chip and a preparation method and application thereof .The preparation method comprises the steps that titanium dioxide particles are subjected to silanization treatment to obtain super-hydrophobic coating liquid, filter paper is soaked in the coating liquid, natural drying is performed at room temperature, and due to the fact that super-hydrophobic nano particles are adsorbed to filter paper filter, a super-hydrophobic filter paper piece of a micro-nano composite structure is obtained; the geometric dimension of the micro-fluidic chip is designed on a mask plate, regional selective exposure is carried out on the micro-fluidic chip through deep ultraviolet light (UV) under the assistance of the mask plate, and therefore the designed pattern of the micro-fluidic chip is copied to the filter paper; the micro-fluidic chip comprises the filter paper and a hydrophilic-hydrophobic layer coating the surface layer of the filter layer; the hydrophilic-hydrophobic layer is provided with at least one hydrophilic flow channel, gradient-changing hydrophilic patterns are designed in the hydrophilic flow channel, and wetting gradient is formed in the flow channel .The microfluid self-driven paper base micro-fluidic chip has the advantages that operation is easy, the manufacturing cost is low, the flow channel with the wetting gradient achieves self drive of microfluid, and the microfluid driving cost is greatly reduced .

Description

technical field [0001] The invention relates to a microfluidic self-driven paper-based microfluidic chip, a preparation method and its application, especially the application in the detection of hydrogen peroxide. Background technique [0002] In 2007, Whitesides first proposed the concept of "microfluidic paper-based analytical devices (μPADs), that is, through various micro-processing techniques, a fluid channel network and related analytical devices are constructed on filter paper to establish a "paper-based analytical device." Miniature laboratory" (lab-on-paper). Compared with traditional microfluidic chips, paper-based microfluidic chips have many significant advantages, such as easy fabrication, low cost, small size and light weight, easy transportation and storage, strong operability, good biocompatibility, and strong functionality. , Post-processing is simple, etc. The paper-based microfluidic chip developed by using paper and its application have become a new fie...

Claims

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Application Information

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IPC IPC(8): B01L3/00G01N21/78
CPCG01N21/78B01L3/502707B01L3/50273B01L2200/12B01L2200/10
Inventor 吴化平刘爱萍张征丁浩柴国钟朱凯曹彬彬吴兵兵
Owner ZHEJIANG UNIV OF TECH
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