Sodium alginate nanofiber surgical dressing containing traditional Chinese medicine antibiotic component berberine and preparation method thereof

A technology of sodium alginate and antibacterial ingredients, applied in medical science, bandages, absorbent pads, etc., can solve problems such as harm to human organs, germ variation, and difficulties in electrospinning of pure sodium alginate, and achieve high-efficiency antibacterial properties and good antibacterial properties , the effect of non-toxic content

Inactive Publication Date: 2016-08-17
TIANJIN TEDA JINSHAN PACKING MFR
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Both proteoglycans (glucosaminoglycan (GAG)) and fibrin, the main components of the natural extracellular matrix in human tissue, have nanostructured components; studies have shown that nanostructured medical materials facilitate cell adhesion and proliferation, and are more functional than micron-scale Therefore, nanofibers have high utilization value in the field of medical dressings; at present, the main method for preparing nanofibers is electrospinning; but because sodium alginate is an anionic polyelectrolyte, its molecular chain is rigid in aqueous solution and have worm-like extensions, pure alginate electrospinning is very difficult
[0004] Wound infection is a key factor affecting wound healing, and it is also an important cause of repeated wounds and even death of patients; therefore, as a good medical dressing, it should have good antibacterial properties; in order to obtain antibacterial properties, traditional medical dressings are generally used in medical dressings. Add a certain amount of antibiotics, or metal ions with antibacterial properties such as nano-silver; however, if the antibiotics are used for a long time, the bacteria will mutate and develop drug resistance, and most of the metal particles are heavy metals. Potentially harmful to human organs

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] (1) Preparation of sodium alginate solution: Sodium alginate was dissolved in deionized water and stirred at room temperature for 2 hours to prepare a sodium alginate solution with a mass fraction of 3 wt%.

[0015] (2) Preparation of polyvinyl alcohol solution: a certain amount of polyvinyl alcohol was dissolved in deionized water and stirred at 90°C for 4 hours to obtain a polyvinyl alcohol solution with a mass fraction of 10 wt%.

[0016] (3) Preparation of electrospinning solution: mix 3wt% sodium alginate solution and 10wt% polyvinyl alcohol solution at a ratio of 4:6 and add 0.5wt%% TX-100 and 0.5wt% % NaCl and stirred for 2 hours to mix evenly, then added sodium alginate and 3wt% polyvinyl alcohol mass of berberine, an antibacterial ingredient in traditional Chinese medicine, stirred for 6 hours and statically defoamed to obtain an electrospinning solution.

[0017] (4) Preparation of nanofiber membrane: inject the electrospinning solution into the needle tube of...

Embodiment 2

[0019] (1) Preparation of sodium alginate solution: Sodium alginate was dissolved in deionized water and stirred at room temperature for 2 hours to prepare a sodium alginate solution with a mass fraction of 3 wt%.

[0020] (2) Preparation of polyvinyl alcohol solution: a certain amount of polyvinyl alcohol was dissolved in deionized water and stirred at 90°C for 4 hours to obtain a polyvinyl alcohol solution with a mass fraction of 10 wt%.

[0021] (3) Preparation of electrospinning solution: Mix 3wt% sodium alginate solution and 10wt% polyvinyl alcohol solution at a ratio of 5:5 and add TX-100 with a mass fraction of 1.5wt%% and 0.5wt% % NaCl was stirred for 2 hours and mixed evenly, then sodium alginate and 4wt% of polyvinyl alcohol were added, and the traditional Chinese medicine antibacterial ingredient berberine was stirred for 6 hours and statically defoamed to obtain an electrospinning solution.

[0022] (4) Preparation of nanofiber membrane: inject the electrospinning ...

Embodiment 3

[0024] (1) Preparation of sodium alginate solution: Sodium alginate was dissolved in deionized water and stirred at room temperature for 2 hours to prepare a sodium alginate solution with a mass fraction of 3 wt%.

[0025] (2) Preparation of polyvinyl alcohol solution: a certain amount of polyvinyl alcohol was dissolved in deionized water and stirred at 90°C for 4 hours to obtain a polyvinyl alcohol solution with a mass fraction of 10 wt%.

[0026] (3) Preparation of electrospinning solution: Mix 3wt% sodium alginate solution and 10wt% polyvinyl alcohol solution at a ratio of 5:5 and add TX-100 with a mass fraction of 1.5wt%% and 0.5wt% % NaCl was stirred for 2 hours to mix evenly, and then sodium alginate and 5wt% polyvinyl alcohol mass of berberine, an antibacterial ingredient in traditional Chinese medicine, were added and stirred for 6 hours, and then statically defoamed to obtain an electrospinning solution.

[0027] (4) Preparation of nanofiber membrane: inject the elect...

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PUM

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Abstract

The invention discloses a sodium alginate nanofiber surgical dressing containing a traditional Chinese medicine antibiotic component berberine. The sodium alginate nanofiber surgical dressing is prepared by sodium alginate, polyving akohol and the traditional Chinese medicine antibiotic component berberine by an electrostatic spinning method; wherein the proportion of a sodium alginate solution to a polyving akohol solution in an electrostatic spinning solution is 4:6-5:5, and content of berberine accounts for 3-6wt% of that of sodium alginate and polyving akohol. Due to no addition of harmful substances such as a strong non-polar solution during a preparation method of the surgical dressing, the used berberine is safe and harmless, bacteria cannot generate drug resistance, the sodium alginate nanofiber surgical dressing containing the traditional Chinese medicine antibiotic component berberine has the advantages of safe and reliable usage and high efficiency bacterinertness, and has escherichia coli antibacterial rate being 92.9-97.1%.

Description

technical field [0001] The invention belongs to the field of polymer materials, and in particular relates to a sodium alginate nanofiber medical dressing containing antibacterial ingredients of traditional Chinese medicine and a preparation method thereof. Background technique [0002] Sodium alginate is a natural polysaccharide mainly from algae plants, mainly composed of 1,4-β-D-mannuronic acid (M unit) and α-L-guluronic acid (G unit), and The protein polysaccharide components in human extracellular matrix are similar; sodium alginate also has excellent characteristics such as wide source, good biocompatibility, controllable biodegradability and non-toxicity, and will not cause antigenic reaction; these characteristics make it It has great application potential in the field of medical dressings. [0003] Both proteoglycans (glucosaminoglycan (GAG)) and fibrin, the main components of the natural extracellular matrix in human tissue, have nanostructured components; studies ...

Claims

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Application Information

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IPC IPC(8): A61L15/44A61L15/28A61L15/24
Inventor 王春红李洪昌李锡伯张桂燕
Owner TIANJIN TEDA JINSHAN PACKING MFR
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