A kind of thioether compound containing pyrimidine, thiadiazole ring and amide structure and application thereof

A thiadiazole ring and compound technology, applied in the field of thioether compounds, can solve the problems of structure and biological activity research that have not been reported in literature and the like, and achieve the effects of simple preparation and good antibacterial activity
CN105859692BInactive Publication Date: 2018-02-27ZHEJIANG UNIV OF TECH +1
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
ZHEJIANG UNIV OF TECH
Publication Date
2018-02-27
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to thioether compounds containing pyrimidine, thiadiazole ring and amide structures and an application thereof; the bactericidal activity of the compounds on colletotrichum orbiculare, botrytis cinerea and rhizoctonia solani are measured, and the general screening concentration is 50 mg / L; measurement results indicate that the compounds (I) having nonsubstituted H in a benzene ring show a certain inhibitory activity on all the tested strains; the compounds Ia (Rn=p-chloro), Id (Rn=o-methyl), Ie (Rn=m-methyl) and If (Rn=p-methyl) have all the inhibition rates on colletrichum orbiculare of more than or equal to 50%, wherein the inhibition rate of the Ie is 77.31%; the compounds Id (Rn=o-methyl), Ie (Rn=m-methyl) and If (Rn=p-methyl) have all the inhibition rates on botrytis cinerea of more than or equal to 50%, wherein the inhibition rate of the Ie is more than 60%; the compounds Id (Rn=o-methyl) and Ie (Rn=m-methyl) have the inhibition rates on rhizoctonia solani of more than or equal to 40%.
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Description

technical field

[0001] The invention relates to thioether compounds containing pyrimidine, thiadiazole ring and amide structure and application thereof. Background technique

[0002] Compounds containing a pyrimidine ring have a wide range of biological activities, such as insecticidal (Chem. Res. Chin. Univ., 2002, 18(4): 481), herbicidal (Pestic. Biochem. Physiol., 2001, 70(2): 86), bactericidal (Tetrahedron, 2000, 56(27): 4739) and other activities play an important role in the creation of new pesticides. Thioether structure compounds are also widely used in the field of pesticides and medicines, such as insecticide (US 4206235, 1980-06-03), anti-tumor (Chin. J. Struct. Chem., 2003, 22: 411), anti- Virus (Eur. J. Med. Chem., 2003, 38:811) and other activities. In addition, amide compounds also have a wide range of biological activities, such as herbicide (Organic Chemistry, 2011, 3(31): 317~323), bactericide (JP 7285942, 1995-10-31), acaricide (JP, 2005060255, 2005 -03...

Claims

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