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Gel paste for treating injured muscles and bones and preparation method thereof

A technique for muscle and bone injuries and gel ointment, applied to medical preparations containing active ingredients, anti-inflammatory agents, bone diseases, etc., can solve the problems of incomplete drug release, inconvenient use, poor quality controllability, etc., and achieve pain relief And anti-inflammatory effect, improve compliance, good drug release performance

Inactive Publication Date: 2016-09-14
CHONGQING ACAD OF CHINESE MATERIA MEDICA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, most prescription medicines are made of fine powder, which has problems such as incomplete drug release, poor quality controllability, and inconvenient use.

Method used

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  • Gel paste for treating injured muscles and bones and preparation method thereof
  • Gel paste for treating injured muscles and bones and preparation method thereof
  • Gel paste for treating injured muscles and bones and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Embodiment 1 The preparation method of the pharmaceutical composition for treating muscle and bone injuries of the present invention

[0040] a. Take the following raw materials:

[0041] 72g Panax notoginseng, 53g frankincense, 62g myrrh, 52g safflower, 78g dried blood, 12g calcined natural copper, 17g antler, 52g dog ridge, 50g acanthopanax, 52g Dipsacus, 6g borneol;

[0042] b. Mix frankincense, myrrh, safflower, dog ridge, Wujiapi, Dipsacus, and Panax notoginseng, soak for 2 hours, and use 8 times the amount, 6 times the amount, and 6 times the amount of water to heat and reflux for three times, each time Extract for 1 hour; dry blood, velvet antler, and natural copper powder; add 95% ethanol to dissolve borneol, and mix well;

[0043] c. Combine the water extract, powder and borneol dissolving solution in step b to obtain.

Embodiment 2

[0044] Embodiment 2 The preparation method of the pharmaceutical composition of the present invention for the treatment of muscle and bone injuries

[0045] a. Take the following raw materials:

[0046] 75g Panax notoginseng, 50g frankincense, 60g myrrh, 50g safflower, 75g dried blood, 10g calcined natural copper, 15g velvet antler, 50g dog spine, 50g acanthopanax, 50g Dipsacus, 5g borneol;

[0047] b. Mix frankincense, myrrh, safflower, dog ridge, Wujiapi, Dipsacus, and Panax notoginseng, soak for 2 hours, and use 8 times the amount, 6 times the amount, and 6 times the amount of water to heat and reflux for three times, each time Extract for 1 hour; dry blood, velvet antler, and natural copper powder; add 95% ethanol to dissolve borneol, and mix well;

[0048] c. Combine the water extract, powder and borneol dissolving solution in step b to obtain.

Embodiment 3

[0049] The preparation of embodiment 3 gel ointment of the present invention

[0050] a, take each crude drug according to embodiment 2 and extract;

[0051] b. Take 236.8g of Carbomer 940, add 6.0g of glycerin, stir evenly, add 10.5g of water, stir evenly, swell for 10h, and make water phase A;

[0052] c. Separately weigh 297.6g of Viscomate NP-700, 256g of aluminum glycolate, 80 parts of kaolin, 15g of deer antler, 10g of calcined natural copper, and 75g of dried blood, mix well, add glycerin, mix well, and make glycerin phase B;

[0053] d, weigh citric acid, add water to dissolve, make water phase C;

[0054] e, Weigh borneol and add ethanol (95%) to dissolve, make phase D;

[0055] f. Weigh 78.4g of PVPK90 and 1.5g of gelatin, add water and water bath (60°C) to swell for 30min, and make phase E;

[0056] g. After phase A and phase B are placed in a water bath (60°C) for 10 minutes, add phase A to phase B and stir evenly, then add phase C, raw material drug liquid, and p...

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Abstract

The invention provides a method for preparing a pharmaceutical composition for treating injured muscles and bones, wherein the method comprises the following steps: a, weighing the raw medicinal materials by weight: 72-78 parts of sangusis draconis, 72-78 parts of pseudo-ginseng, 47-53 parts of frankincense, 56-62 parts of myrrh, 46-52 parts of safflower, 8-12 parts of calcined natural copper, 14-17 parts of pilos antler, 48-52 parts of rhizoma cibotii, 48-50 parts of cortex acanthopanacis, 48-52 parts of radix dipsaci and 3-6 parts of borneol; b, adding water into the frankincense, myrrh, safflower, rhizoma cibotii, cortex acanthopanacis, radix dipsaci and pseudo-ginseng, boiling and extracting or adding ethanol and extracting; and grinding the sangusis draconis, pilos antler and calcined natural copper into powder; adding a 95% ethanol to borneol, dissolving, and evenly mixing; and c, merging the water or ethanol extract of the step B, the powder and the borneol dissolved liquid, to obtain the product. The prepared gel paste improves patient compliance, has relatively good drug release properties, and can have the drug continuously released.

Description

technical field [0001] The invention relates to a gel ointment for treating muscle and bone injuries. Background technique [0002] Injured tendons and broken bones is a common and frequently-occurring disease, often occurring in daily life, often accompanied by redness, swelling, congestion, pain, dysfunction and other symptoms. The treatment for this type of disease generally has a long course of treatment and slow recovery. External application of drugs to treat fractures and bone injuries has the characteristics of short course of treatment and convenient use, and is also one of the most commonly used methods for fracture treatment in traditional medicine. [0003] Fracture healing is a continuous process. Generally speaking, it can be divided into three periods. The first phase is called the hematoma organization phase. Within 6-8 hours after the fracture, the hematoma begins to form blood clots, capillaries proliferate, various fibrous cells invade, the hematoma be...

Claims

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Application Information

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IPC IPC(8): A61K36/889A61K36/896A61K9/06A61P29/00A61P19/08A61K33/26A61K35/32A61K31/045
Inventor 杨荣平王云红张传辉蒋瑶贾成友秦伟瀚赵凤平
Owner CHONGQING ACAD OF CHINESE MATERIA MEDICA
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