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Chinese traditional medicine water extract for treating diabetic nephropathy as well as preparation method and application thereof

A technology for diabetic nephropathy and extracts, applied in the field of traditional Chinese medicine extracts, can solve problems such as lack of specific means for the treatment of diabetic nephropathy, and achieve the effects of reducing urinary protein excretion rate, content and urea content.

Inactive Publication Date: 2016-09-21
PEKING UNIV FIRST HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The current treatment of diabetic nephropathy lacks effective specific means

Method used

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  • Chinese traditional medicine water extract for treating diabetic nephropathy as well as preparation method and application thereof
  • Chinese traditional medicine water extract for treating diabetic nephropathy as well as preparation method and application thereof
  • Chinese traditional medicine water extract for treating diabetic nephropathy as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Embodiment 1, the extraction of Chinese medicine extract

[0029] Weigh the following prescription:

[0030] Dijincao 120g, Salvia 160g, Raw Astragalus 120g, Anemarrhena 80g, Coptis 48g.

[0031] After mixing the traditional Chinese medicines, add them to 8 times the mass of water, soak for 60 minutes, then decoct and extract twice for 1 hour each time, filter, combine the filtrates, concentrate, and evaporate to dryness, which is the Chinese medicine extract of the present invention.

[0032] The Chinese medicine extract prepared in this example is in the form of extract, 182g in total, so 1g of the Chinese medicine extract is equivalent to 2.90g of the Chinese medicine composition.

Embodiment 2

[0033] Embodiment 2, the influence of Chinese medicine extract of the present invention on blood sugar and renal function

[0034] 1. Animals

[0035] 40 male spontaneous type 2 diabetes model KK-Ay mice, 8w old, Beijing Huafukang Biotechnology Co., Ltd., license number: SCXK (Beijing) 2014-0004; 10 healthy male C57BL / 6J mice, 8w old, Beijing Weitong Lihua Experimental Animal Technology Co., Ltd., license number: SCXK (Beijing) 2012-0001. KK-Ay mice were fed with high-fat diet, Beijing Huafukang Biotechnology Co., Ltd., license number: SCXK (Beijing) 2014-0008; C57BL / 6J mice were fed with normal diet. All animals had free access to water, and were adaptively fed for 1 week at room temperature (22±1)°C in an SPF environment with a 12-h photoperiod. Take blood from the tip of the tail to measure the random blood glucose of KK-Ay mice ≥11.1mmol·L -1 Or fasting blood glucose (FBG) ≥ 7.0mmol·L -1 That is, as a model of diabetes.

[0036] 2. Dosage of mice in each group

[003...

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Abstract

The invention discloses Chinese traditional medicine water extract for treating diabetic nephropathy as well as a preparation method and application thereof. The preparation method comprises the following steps: extracting a Chinese traditional medicine composition with water; filtering to obtain filtrate; and concentrating and drying the filtrate to obtain Chinese traditional medicine extract, wherein the Chinese traditional medicine composition is composed of humifuse euphorbia herb, salvia miltiorrhiza, raw radix astragalis, rhizoma anemarrhenae and coptis chinensis and the mass ratio of the humifuse euphorbia herb to the salvia miltiorrhiza to the raw radix astragalis to the rhizoma anemarrhenae to the coptis chinensis is (1.32-5.34) to (1.76-7.12) to (0.88-6) to (0.88-3.56) to 1. The Chinese traditional medicine extract disclosed by the invention is obtained by carrying out alcohol extraction on the Chinese traditional medicine composition (composed of the humifuse euphorbia herb, the salvia miltiorrhiza, the raw radix astragalis, the rhizoma anemarrhenae and the coptis chinensis) and the method is simple; the Chinese traditional medicine extract disclosed by the invention can be used for reducing the concentration of blood glucose, reducing the content of urine microalbumin, reducing the content of urea in urine and reducing the specific value of the content of the urine microalbumin and urine creatinine in urine, so that the Chinese traditional medicine extract can be used for preventing and / or treating the diabetic nephropathy.

Description

technical field [0001] The invention relates to a Chinese medicinal water extract for treating diabetic nephropathy, a preparation method and application thereof, and belongs to the field of traditional Chinese medicinal extracts. Background technique [0002] Diabetic nephropathy is a serious microvascular complication of diabetes, the main cause of end-stage renal failure, and one of the main causes of death and disability in diabetes. At present, there is no effective specific means for the treatment of diabetic nephropathy. Traditional Chinese medicine has accumulated rich experience in the field of treatment of diabetic nephropathy, so it is expected to provide a traditional Chinese medicine extract that can reduce the excretion rate of urinary protein in patients with diabetic nephropathy, delay the decline of renal function in patients, and improve the quality of life of patients. Contents of the invention [0003] The object of the present invention is to provide ...

Claims

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Application Information

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IPC IPC(8): A61K36/8964A61P3/10A61P13/12
CPCA61K36/47A61K36/481A61K36/537A61K36/718A61K36/8964A61K2236/331A61K2300/00
Inventor 王学美黎巍威洪金妮富宏屠鹏飞姜勇曾祥腾高云佳
Owner PEKING UNIV FIRST HOSPITAL
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