Method for preparing D-pantoyl lactone by fermentation

Abstract

The invention provides a method for preparing D-pantoyl lactone by fermentation. The method comprises the following steps: culturing fusarium oxysporum in a culture medium; (2) mixing the cultured fusarium oxysporum with a substrate and hydrolyzing to obtain D-pantoic acid; (3) carrying out lactonization on the D-pantoic acid in the step (2) to obtain the D-pantoyl lactone, wherein the culture medium is prepared from 1 percent to 10 percent of glycerol, 0.2 percent to 2 percent of peptone, 0.2 percent to 2 percent of yeast extract, 0.5 percent to 5 percent of maize slurry, 0.05 percent to 0.2 percent of spirulina polysaccharide, 0.1 percent to 1 percent of glycine and the balance of water.

Description

technical field

[0001] The invention relates to the field of biochemical industry, and more specifically relates to a method for fermenting and preparing D-pantolactone. Background technique

[0002] Pantothenic acid, also known as pantothenic acid, vitamin B 5 , widely exists in the biological world, is the main raw material for the synthesis of coenzyme A in animals, and its main function is to participate in the metabolism of sugar, fat and protein. A deficiency in pantothenic acid in the body can cause muscle aches or cramps, adrenal insufficiency and hypofunction, poor concentration, numb hands and feet, constipation, lack of energy, exhaustion after light exercise, anxiety, nervousness, and teeth grinding. Pantothenic acid is widely used in the fields of medicine, feed and food because of its unique biochemical functions. Its active ingredient is D-configuration D-pantothenic acid, but because pantothenic acid is unstable, its industrial application usually uses deri...