Chitosan bleeding stopping and pain relieving powder and preparation method thereof

The technology of chitosan and analgesic powder is applied in the field of chitosan hemostatic and analgesic powder and its preparation field, which can solve the problems of insignificant analgesic effect, complicated organic reagents and high overall cost, improve the hemostatic and analgesic effect and simplify the treatment process. , increase the effect of pain relief

Inactive Publication Date: 2016-10-12
HENAN TUOREN BEST MEDICAL DEVICE CO LTD
View PDF3 Cites 6 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The emulsification and cross-linking method is often used in the preparation process, and the use of organic reagents is complicated. For the later sample processing process, the process is complicated and easy to cause environmental pollution.
The overall cost is high and expensive, but the hemostatic effect is similar, and the analgesic effect is not obvious or has no such effect

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Dissolve 2 g of sodium alginate and 0.5 g of carboxymethyl chitosan into 60 mL and 50 mL of distilled water, respectively. Add the carboxymethyl chitosan solution into the sodium alginate solution, and stir and mix thoroughly. Then add 40 mL of 1.0 g of calcium chloride solution, stir well, cross-link to form a hydrogel system, let it stand for precipitation, and discard the supernatant. Wash 3 times with distilled water until the pH is 5.0-7.0, dry in vacuum, grind, sieve, and make powder. Add appropriate amount of lidocaine hydrochloride 0.1g and thrombin 0.4mg to the powdery solid, mix well, and grind into powder , irradiated and sterilized, and packaged as a hemostatic and pain-relieving powder.

[0018] In rat femoral artery and liver hemorrhage models, the hemostatic and analgesic powder produced was significantly better than Yunnan Baiyao and other similar products. The mouse tail flick test proved that the analgesic effect is good.

Embodiment 2

[0020] Dissolve 5 g of sodium alginate and 1 g of carboxymethyl chitosan into 150 mL and 100 mL of distilled water, respectively. Add the carboxymethyl chitosan solution into the sodium alginate solution, and stir and mix thoroughly. Then add 80mL of 2.5g calcium chloride solution, stir well, cross-link to form a hydrogel system, let it stand for precipitation, and discard the supernatant. Wash with distilled water three times until the pH is 5.0-7.0, dry in vacuum, grind, sieve, and powder. An appropriate amount of lidocaine hydrochloride (0.1%) and 1 mg of thrombin are added to the powdery solid, mixed evenly, irradiated and sterilized and packaged to become hemostatic and pain-relieving powder.

[0021] In rat femoral artery and liver hemorrhage models, the hemostatic and analgesic powder produced was significantly better than Yunnan Baiyao and other similar products. The mouse tail flick test proved that the analgesic effect is good.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
particle diameteraaaaaaaaaa
Login to view more

Abstract

The invention relates to a chitosan hemostatic and pain-relieving powder and a preparation method thereof. The chitosan hemostatic and pain-relieving powder is prepared by mixing carboxymethyl chitosan, sodium alginate, thrombin and lidocaine hydrochloride. The ratio is: 0.1-10 parts of carboxymethyl chitosan, 0.1-10 parts of sodium alginate, 0.0004 parts of thrombin, 0.1-2 parts of lidocaine hydrochloride, cross-linked with calcium chloride, washed, dried, and ground into powder , has the advantages of simple and green preparation method, low production cost, high water absorption swelling rate, convenient use, and good hemostatic and analgesic effects.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and in particular relates to a chitosan hemostatic and pain-relieving powder and a preparation method thereof. Background technique [0002] Hemorrhage is the first cause of death in war injuries and the second cause of death in trauma. Hemorrhage is also the main cause of death in the operating room of trauma patients. Rapid and effective control of hemorrhage can significantly reduce the death caused by excessive bleeding; Timely and rapid analgesia can significantly reduce the pain caused by pain to injured patients. Hemostasis can reduce blood loss during surgery, keep the surgical field clear, prevent important tissue damage, ensure surgical safety and postoperative wound healing, reduce infection, shorten operation time, It is of great significance to the prognosis of patients; pain is a protective reaction produced by the body after being subjected to noxious stimuli, and is o...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/00A61L24/08A61L24/10
CPCA61L24/0015A61L24/08A61L24/108A61L2300/204A61L2300/254A61L2300/402A61L2300/418C08L5/08C08L5/04C08L89/00
Inventor 崔景强徐鹏乐牛利卫张洪亮
Owner HENAN TUOREN BEST MEDICAL DEVICE CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap