Catalyst process-based aminolevulinic acid preparation method
A technology of aminolevulinic acid and catalyst method, which is applied in the preparation of organic compounds, chemical instruments and methods, and cyanide reaction preparation, etc., can solve the problems of complicated process steps, high precision requirements, poor product stability, etc. The process method is simple, the product purity is high, and the production cycle is short.
Inactive Publication Date: 2016-10-12
北京华清科创科技开发有限公司
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Problems solved by technology
These manufacturers generally use succinic anhydride as the starting material, and go through 5 to 7 steps of very complicated procedures, and each reaction step must go through refining processes such as chromatography, distillation, and recrystallization. The process steps are complicated and the operation process requires high precision. Higher, the product yield is less than 10%, and the cost remains high
[0003] In addition, when these manufacturers produce aminolevulinic acid, most of them use toxic substances such as cyanide and chromate, which cause serious environmental pollution, and the increase in environmental protection costs further increases their production costs.
In the biological fermentation method, although there are no toxic by-products, and the steps are completed in a single step, the yield is less than 1%, the purification is difficult, the initial investment is high, and the deviation of product concentration and effect is relatively large, and the product stability is poor. , the quality cannot be guaranteed
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[0027] Preparation examples
[0028] The present invention prepares aminolevulinic acid according to the following steps:
[0029] (1) Synthesis of aminolevulinic acid (ALA): A cholesterol of molecular formula I and aminoketoester of molecular formula II undergo a rapid oxidation-reduction reaction under the catalysis of a catalyst-nano activated carbon to produce most of the shallow product ALA and a small amount Aminolevulinic acid derivatives, the ratio of ALA to aminolevulinic acid derivatives is (9-34):6, the reaction is carried out at 50-100℃ in the dark, and the pH of the reactants is controlled within the range of 7-8. The specific reaction The formula is as follows:
[0030]
[0031] The specific structure of R1 in formula II is shown in Table 1;
[0032] The dosage ratio (mass ratio) of molecular formula I and molecular formula II is shown in Table 2;
[0033] The amount of aminolevulinic acid derivative and ALA produced by the reaction is shown in Table 3;
[0034] See Table...
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The invention relates to the field of organic chemical preparation, and discloses a method for preparing aminolevulinic acid based on a catalyst method. The invention comprises the following steps: synthesizing aminolevulinic acid (ALA): the substance of molecular formula I reacts with the substance of molecular formula II under the catalysis of activated carbon to generate ALA; filtering: the product obtained in step (1) is cooled and then filtered; salt formation and impurity removal: Add hydrochloric acid to the filtrate, mix well and centrifuge, evaporate and concentrate the supernatant; purification: add the concentrate to acetone, mix well, and dry to obtain aminolevulinic acid. The invention has the advantages of simple process, low cost, short production cycle, energy saving and environmental protection, high product yield and high purity.
Description
Technical field [0001] The invention relates to the field of organic chemistry preparation, in particular to a method for preparing aminolevulinic acid based on a catalyst method. Background technique [0002] Aminolevulinic acid (ALA) sold on the international market is mainly produced by two methods: chemical synthesis and biological fermentation. At present, aminolevulinic acid on the market is mainly produced by TCI, Merck, Sigma and other pharmaceutical companies through chemical synthesis. These manufacturers generally use succinic anhydride as the starting material and go through 5 to 7 very complicated procedures, and each reaction step has to go through refining processes such as chromatography, distillation, and recrystallization. The process steps are complicated and the operation process accuracy is required. Higher, the product yield is less than 10%, and the cost remains high. [0003] In addition, when these manufacturers produce aminolevulinic acid, most of them u...
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Login to View More IPC IPC(8): C07C229/22C07C227/18C07C227/16C07C227/40
CPCC07C227/18C07C227/16C07C227/40
Inventor 罗发洪李琴
Owner 北京华清科创科技开发有限公司