Platinum nano wire modified microelectrode array and preparation method thereof

Abstract

The invention provides a platinum nano wire modified microelectrode array, and a platinum nano wire modification layer is arranged on the electrode surface of the microelectrode array. The microelectrode array takes platinum nano wires as surface modification layer, which is tightly bonded with the microelectrode substrate, and electrode failure due to disconnection can be prevented. The surface area of a modified microelectrode is greatly increased, electrochemistry impedance is greatly reduced, and the electrode charge injection capacity and charge storage capability are substantially increased. The power consumption of an implanted system can be reduced, and the electrical stimulation effect is improved. The modification layer has good biological compatibility, so that the application of the platinum nano wire modified microelectrode array in the biomedical field is increased. The invention further provides a preparation method of the platinum nano wire modified microelectrode array.

Description

technical field [0001] The invention relates to the technical field of microelectrode surface modification, in particular to a platinum nanowire-modified microelectrode array and a preparation method thereof. Background technique [0002] As one of the most important implantable microdevices, nerve stimulation / recording electrodes are used to stimulate nerve tissue or record nerve electrical signals (ECG, EEG, cortical electrical signals, etc.), and are widely used in brain-computer interface, neurophysiology, It is a very important research and diagnostic tool in life science fields such as brain science research. [0003] In order to reduce the trauma of implantation, provide more clinical stimulation modes and improve the resolution of electrical stimulation or recording, nerve stimulation electrodes / recording are developing in the direction of miniaturization and arraying—microelectrode arrays. However, the reduction in electrode size brings with it the problem of incre...

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Problems solved by technology

[0004] Specifically, the methods for surface modification of microelectrode arrays are generally as follows: 1. A layer of platinum black (Anal. Chem. 1987, 59, 217-218) is modified on the surface of the electrode. At least one order of magnitude smaller, but its mechanical stability is very poor, and its modification layer contains toxic substances such as lead, making it unsuitable for applications in the biomedical field; 2. A layer of platinum ash is modified on the electrode surface (US Patent 6974533, 2005), this coating has good mechanical stability and is non-toxic, but its surface roughness is not large enough, so that its surface modification in ultra-high resolution electrodes is limited; 3, the iridium oxide (Eng. Med.Biol.Soc.2004,4153-4156) or conductive polymer (J.Biomed.Mater.Res.2001,56,261-272) modified microelectrode has excellent electrochemical performance (such as high charge injection ability) , but these materials have poor adhesion and are easily detached from the electrode surface during stimulation

[0005] In addition, it is worth mentioning that the above methods are all electrochemical modification methods, and corresponding electrochemical equipment is required for modification. At the same time, this method has high requirements on the environment, and is relatively time-consuming and expensive.

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