A kind of nicotinamide production method

A production method, the technology of nicotinamide, which is applied in the field of nicotinamide production, can solve problems such as the difficulty of solvent recycling, the increase of equipment production load, and the azeotropy of alcohol and water, so as to reduce the probability of agglomeration or agglomeration and reduce the emission rate , The effect of reducing the amount of waste liquid discharge

Inactive Publication Date: 2019-04-09
GUIZHOU RES INST OF CHEM IND
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, most of the nicotinamide products obtained by the nicotinamide production process in the prior art are in the form of needle-like crystals or powder, which makes it easy to agglomerate or agglomerate after exposure to air, which affects the appearance of the product
[0004] In the prior art, most of the production methods for nicotinamide are mixed with alcohol and water to obtain a solvent, which is then used to promote the hydrolysis of 3-cyanopyridine, so that the yield and purity of nicotinamide products are relatively high ; Such as the production method of high-purity nicotinamide with the patent application number CN201410672124 and the preparation method of the nicotinamide with the patent number CN201010192136, which all use ethanol or C1-C4 alcohol to process, and carry out temperature rise to remove alcohol at the end At this time, in the process of removing the solvent by raising the temperature, the loss of alcohol is uncontrollable, and alcohol and water are prone to azeotrope, which makes it difficult to recycle the solvent. It will increase the production load of the equipment, making the cost of nicotinamide production higher

Method used

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  • A kind of nicotinamide production method
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  • A kind of nicotinamide production method

Examples

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Effect test

Embodiment 1

[0021] A production method of nicotinamide, which is prepared by using water, 3-cyanopyridine, and manganese dioxide in a weight ratio of 50:40:2, putting them into a reaction tank, controlling the temperature at 95°C, and stirring for 8 hours. Therefore, the stirring speed is to control the solution so that bumping does not occur.

Embodiment 2

[0023] A method for producing nicotinamide, which uses water, 3-cyanopyridine, and manganese dioxide in a weight ratio of 60:50:5, puts them into a reaction tank, controls the temperature at 95-110°C, and stirs the hydrolysis reaction After 10 hours, it is obtained through the steps of hot filtration, decolorization, concentration, filtration, recrystallization, refiltration, dissolution, granulation, and drying. During the stirring process, it is advisable to control the solution from bumping.

Embodiment 3

[0025] A method for producing nicotinamide, which uses water, 3-cyanopyridine, and manganese dioxide in a weight ratio of 55:45:3, puts them into a reaction tank, controls the temperature at 95-110°C, and stirs and hydrolyzes for 9 hours , and then obtained through the steps of hot filtration, decolorization, concentration, filtration, recrystallization, refiltration, dissolution, granulation, and drying. During the stirring process, it is advisable to control the solution from bumping. The hot filtration is to filter it immediately after the hydrolysis reaction is completed, and adopt two suction filtration treatments, and return the solid to the hydrolysis step; the decolorization is to pass the filtrate after the hot filtration through the decolorization treatment in the activated carbon decolorizer ; The concentration is to distill 20 parts by weight of water from the decolorized material, and then it is cooled and crystallized until the amount of crystals no longer increas...

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Abstract

The invention relates to the technical field of fine chemical engineering, in particular to a nicotinamide production method. The method comprises the steps that in the hydrolytic process, water is adopted as a solvent, manganese dioxide is adopted as a catalyst, 3-cyanopyridine is subjected to heating and hydrolysis reaction, in the hydrolysis reaction process, alcohol is not needed to serve as a solvent, the production cost of nicotinamide is reduced, the yield of nicotinamide is high and can reach 85% or above, the purity of the product is determined through a high performance liquid chromatography method, the purity can reach 99.93% or above, the cost of recycling the solvent and the catalyst manganese dioxide is effectively reduced, the waste rate of the raw materials is decreased, and the emission rate of liquid waste is decreased.

Description

technical field [0001] The invention relates to the technical field of fine chemicals, in particular to a method for producing nicotinamide. Background technique [0002] The common name of nicotinamide is VB3, and its chemical name is 3-pyridinecarboxamide. It is a white needle-like crystal or powder with a melting point of 129-131°C and is soluble in ethanol and glycerin. Niacinamide is a component of coenzyme I and coenzyme II. When lacking, it can affect the normal respiration and metabolism of cells and cause pellagra. Therefore, nicotinamide is widely used in food and feed additives, pharmaceuticals and raw materials, biochemical agents, color development agents, electroplating brighteners and other fields. [0003] The production of nicotinamide is mainly based on the main synthesis method of 3-cyanopyridine through microbial hydrolysis or metal oxide catalyzed hydrolysis. At present, the yield of nicotinamide produced in China is relatively high, which can reach mo...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D213/82
CPCY02P20/584
Inventor 龙来早邹金鑫马福波刘亚明苏占军
Owner GUIZHOU RES INST OF CHEM IND
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