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Eye implantation type ketorolac tromethamine-carrying sustained release preparation and preparation method thereof

A type of technology for carrying tromethamine and tromethamine ketorolac, applied in the field of medicine, can solve the problems of toxic and side effects of eye tissue, long course of uveitis, short drug half-life, etc., and achieve controlled drug release. The effect of time, drug sustained release time and good biocompatibility

Inactive Publication Date: 2016-11-16
BEIJING TONGREN HOSPITAL AFFILIATED TO CAPITAL MEDICAL UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the half-life of the drug in the eye is relatively short, and the course of uveitis is long, so frequent injections of the drug are necessary to maintain the therapeutic concentration in the eye
Frequent injections are not only difficult for patients to accept, but also easily cause various complications such as vitreous hemorrhage, retinal detachment, and endophthalmitis
In addition, direct injection administration will cause large fluctuations in the concentration of the drug in the eye, even beyond the therapeutic window, resulting in toxic side effects on ocular tissues

Method used

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  • Eye implantation type ketorolac tromethamine-carrying sustained release preparation and preparation method thereof
  • Eye implantation type ketorolac tromethamine-carrying sustained release preparation and preparation method thereof
  • Eye implantation type ketorolac tromethamine-carrying sustained release preparation and preparation method thereof

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Embodiment Construction

[0027] The present invention is further described in conjunction with the following examples.

[0028] The preparation method of a kind of intraocular implant type ketorolac tromethamine sustained-release preparation provided by the embodiment of the present invention, such as figure 1 and figure 2 Shown, comprise the following steps: (1) prepare ketorolac tromethamine microspheres: adopt such as figure 1 In the spray drying process shown, the mixed emulsion of ketorolac tromethamine and polycaprolactone is mixed uniformly to ensure that ketorolac tromethamine is evenly dispersed in the solution of polycaprolactone; The mixture of trometamol and polycaprolactone is placed in a high-temperature dryer, and is atomized into tiny droplets through the spray head of the sprayer. When these small droplets come into contact with hot air, the water that dissolves the wall material is heated and evaporates rapidly. , so that the wall material is solidified, thereby wrapping the core ...

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Abstract

The present invention relates to the field of biomedicine, in particular to a preparation method of intraocular implantable ketorolac tromethamine sustained-release preparation, comprising the following steps: (1) preparing ketorolac tromethamine microspheres: The mixed emulsion of ketorolac tromethamine and polycaprolactone is prepared by spray drying process, and the mixed emulsion of ketorolac tromethamine and polycaprolactone is placed in a high-temperature dryer, and passed through the spray head Atomized into tiny droplets, the droplets are ketorolac tromethamine microspheres; (2) film casting: the ketorolac tromethamine microspheres prepared in step (1) Disperse in the medium, then add polycaprolactone to the medium to form a medium-polycaprolactone mixed solution, and finally solidify the medium-polycaprolactone mixed solution dropwise to form a film, and obtain ketorolac ambutene Triol sustained release formulation. This new type of sustained-release preparation has broad application prospects and economic and social benefits in the ophthalmic drug delivery route.

Description

technical field [0001] The present invention relates to the field of medicine, in particular to an intraocular implanted ketorolac tromethamine sustained-release preparation and a preparation method thereof. The sustained-release preparation is a non-steroidal anti-inflammatory drug ketorolac tromethamine A complex sustained-release preparation is formed with a degradable polymer material, and the sustained-release preparation is prepared by a spray-drying process. Background technique [0002] Non-steroidal anti-inflammatory drugs (non-steroidal anti-inflammatory drugs, NSAIDS) have been used in clinical practice for nearly a hundred years. Since glucocorticoids were widely used in clinical practice, the application of such drugs was once reduced. However, because glucocorticoids can cause dependence, the drug cannot be stopped immediately in the short term, and long-term use can cause many serious adverse reactions, so the research on NSAIDS has been re-emphasized. [000...

Claims

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Application Information

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IPC IPC(8): A61K9/70A61K31/407A61K47/34A61K47/42A61P27/02A61P29/00
CPCA61K9/0002A61K9/0051A61K9/7007A61K31/407A61K47/34A61K47/42
Inventor 毛迎燕刘武王宁利杜丽华
Owner BEIJING TONGREN HOSPITAL AFFILIATED TO CAPITAL MEDICAL UNIV
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