Eye implantation type ketorolac tromethamine-carrying sustained release preparation and preparation method thereof
A type of technology for carrying tromethamine and tromethamine ketorolac, applied in the field of medicine, can solve the problems of toxic and side effects of eye tissue, long course of uveitis, short drug half-life, etc., and achieve controlled drug release. The effect of time, drug sustained release time and good biocompatibility
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[0027] The present invention is further described in conjunction with the following examples.
[0028] The preparation method of a kind of intraocular implant type ketorolac tromethamine sustained-release preparation provided by the embodiment of the present invention, such as figure 1 and figure 2 Shown, comprise the following steps: (1) prepare ketorolac tromethamine microspheres: adopt such as figure 1 In the spray drying process shown, the mixed emulsion of ketorolac tromethamine and polycaprolactone is mixed uniformly to ensure that ketorolac tromethamine is evenly dispersed in the solution of polycaprolactone; The mixture of trometamol and polycaprolactone is placed in a high-temperature dryer, and is atomized into tiny droplets through the spray head of the sprayer. When these small droplets come into contact with hot air, the water that dissolves the wall material is heated and evaporates rapidly. , so that the wall material is solidified, thereby wrapping the core ...
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