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Collagen sponge dressing with medical base cloth

A collagen sponge and base cloth technology, which is applied in the field of medical materials, can solve the problems of poor biocompatibility and comfort of dressings, reduced air permeability of medical base cloth, and unfavorable exudate discharge, etc., and achieves reduced damage and shrinkage. Low rate, good protection and the effect of isolating external infections

Inactive Publication Date: 2016-11-16
SUZHOU JINGZHUO BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the dressing composed of collagen sponge and medical base cloth is to paste the collagen sponge on the medical base cloth material coated with natural rubber paste or medical hot melt adhesive. These medical adhesives make the dressing biocompatible and comfortable. Sexual deterioration, easy to cause allergies
Moreover, the air permeability of the medical base cloth is reduced after being coated with medical glue, which is not conducive to the discharge of exudate for wounds with more exudate, so there is still a need for improvement.

Method used

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  • Collagen sponge dressing with medical base cloth
  • Collagen sponge dressing with medical base cloth
  • Collagen sponge dressing with medical base cloth

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] (1) Dilute the collagen solution to a collagen content of 0.4%.

[0038] (2) Cut the medical absorbent cotton gauze with a yarn count density of 21×32 and a textile density of 110×100 into the size of the mold, spread the cut medical absorbent cotton gauze on the bottom of the mold, calculate the area of ​​the medical absorbent cotton gauze, and calculate the area of ​​the medical absorbent cotton gauze as 150g / m 2 Add purified water in proportion to make the medical absorbent cotton gauze close to the bottom of the mold.

[0039] (3) Freeze-drying: Pour 0.4% collagen solution into a mold covered with medical absorbent cotton gauze, pre-freeze at -80°C for 4 hours, dry at -25°C for 24 hours once, and dry at 10°C for 8 hours. That is, a collagen sponge with a size of 50mm×50mm×2mm was obtained.

[0040](4) Cross-linking: put the freeze-dried collagen sponge containing the medical base cloth into a vacuum drying oven, and vacuum-dry at 100° C. for 24 hours to perform t...

Embodiment 2

[0042] (1) Dilute the collagen aqueous solution to a collagen content of 0.8%.

[0043] (2) Cut the medical absorbent cotton gauze with a yarn count density of 32×32 and a textile density of 120×120 into the size of the mold, spread the cut medical absorbent cotton gauze on the bottom of the mold, calculate the area of ​​the medical absorbent cotton gauze, and calculate the area of ​​the medical absorbent cotton gauze according to 200g / m 2 Add water for injection according to the ratio, so that the medical absorbent cotton gauze is close to the bottom of the mold.

[0044] (3) Freeze-drying: Pour 0.8% collagen solution into a mold covered with medical absorbent cotton gauze, pre-freeze at -80°C for 5h, dry at -25°C for 30h once, and dry at 10°C for 10h to obtain a size of 50mm×50mm×3mm collagen sponge.

[0045] (4) Cross-linking: put the freeze-dried collagen sponge containing the medical base cloth into a vacuum drying oven, and vacuum-dry at 100° C. for 36 hours to carry ...

Embodiment 3

[0047] (1) Dilute the aqueous collagen solution to a collagen content of 1.2%.

[0048] (2) Cut the medical absorbent cotton gauze with a yarn count density of 40×40 and a textile density of 100×120 into the size of the mold, spread the cut medical absorbent cotton gauze on the bottom of the mold, and calculate the area of ​​the medical absorbent cotton gauze as 300g / m 2 Add purified water in proportion to make the medical absorbent cotton gauze close to the bottom of the mold.

[0049] (3) Freeze-drying: Pour 1.2% collagen solution into a mold covered with medical absorbent cotton gauze, pre-freeze at -80°C for 6 hours, dry at -25°C for 35 hours once, and dry at 10°C for 12 hours to obtain a size of 50mm ×50mm×5mm collagen sponge.

[0050] (4) Cross-linking: put the freeze-dried collagen sponge containing the medical base cloth into a vacuum drying oven, and dry at 100° C. for 48 hours to carry out thermal cross-linking.

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Abstract

The invention discloses a collagen sponge dressing with a medical base cloth. The collagen sponge dressing is prepared from the medical base cloth and a collagen solution through freeze drying and thermal crosslinking. The medical base cloth and the collagen solution form a collagen sponge after being frozen and dried, and no other ingredient is contained between the medical base cloth and the collagen sponge. The collagen sponge dressing with the medical base cloth has good hydroscopicity, air permeability and mechanical property, is good in attachment performance, low in shrinking percentage, convenient to fix when used and convenient to remove after being used, contains no matter, has good biocompatibility, is applicable to various skin wounds, and has the effects of protecting and promoting wound repair.

Description

technical field [0001] The invention relates to a medical material for protecting and promoting wound repair, in particular to a collagen sponge dressing containing a medical base cloth. Background technique [0002] As one of the main components of extracellular matrix, collagen has low immunogenicity and good biocompatibility, and is widely used in wound repair process. The sponge dressing made of collagen can absorb wound exudate, has good air permeability and comfort, protects the wound and promotes wound repair at the same time, and is an ideal wound dressing. However, there are still some problems in practical application, such as insufficient mechanical strength, its inherent shape and structure will be changed after absorbing liquid and swelling, which is not conducive to fixation, and the isolation effect is limited. Therefore, at present, the method of compounding collagen sponge with other synthetic polymers or natural polymer materials is often used to improve t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/32A61L15/40A61L15/42
CPCA61L15/325A61L15/40A61L15/425A61L2300/25A61L2300/412A61L2300/608
Inventor 刘富俊孙海胜孙莉嫚李好雨杨秀甫杨中科杨安顺胡正洋蒋小龙何龙金玉叶东
Owner SUZHOU JINGZHUO BIOTECH