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Wettability-guided preparation method of microcapsules and application of microcapsules

A technology of microcapsules and infiltration, applied in the field of preparation of microcapsules, can solve the problems of complex devices, difficult to construct, difficult to modify, etc., and achieves the effects of good control, simplified process and improved repeatability

Active Publication Date: 2016-11-23
SOUTHEAST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, most of the existing microfluidic methods for preparing multiple emulsions require the use of specialized devices, which are usually either complex and difficult to construct or difficult to modify, such as multi-stage assembled capillary devices or devices prepared by photolithography, etc.

Method used

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  • Wettability-guided preparation method of microcapsules and application of microcapsules
  • Wettability-guided preparation method of microcapsules and application of microcapsules
  • Wettability-guided preparation method of microcapsules and application of microcapsules

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Example 1 Preparation of single-component ethoxylated trimethylolpropane triacrylate (ETPTA) microcapsules:

[0036] 1. Generation of ETPTA double emulsion: with figure 1 The device shown in the schematic diagram is similar, but the injection tube is a capillary tube with seven holes, and the injection tube is treated with a 2vol.%-10vol.% acetone solution of octadecyltrimethoxysilane; Assemble the microfluidic device with cover glass, sampling needle and quick-drying adhesive, the whole device is as follows: Figure 4Shown; The core solution is an aqueous solution containing 2wt% F108, and the shell solution is an ETPTA solution containing 1Wt% photoinitiator (HMPP). The continuous phase is methyl silicone oil KF-96 (0.65CS);

[0037] 2. The microfluidic device wraps the chip and all ETPTA pipes and syringes with black tape or tin foil to prevent the device from being blocked during UV curing; connect the syringe containing the three-phase solution to the correspond...

Embodiment 2

[0039] Example 2 Preparation of polyethylene glycol diacrylate (PEGDA) microcapsules loaded with oil-soluble dyes of three colors:

[0040] 1. Generation of PEGDA double emulsion: as figure 1 As shown, the injection tube is a capillary tube with seven holes, and the microfluidic device is assembled by using slide glass, cover glass, sampling needle and quick-drying glue. The inner core solutions (A, B, C) are silicone oil solutions of red, yellow, and blue oil-soluble dyes, respectively, and the shell solution is PEGDA hydrogel polymerization precursor solution containing 1wt% photoinitiator. The continuous phase is subunit silicone oil KF-96 (0.65CS). Connect the syringes filled with the biphasic solution to the corresponding glass capillary channels on the microfluidic chip.

[0041] . The microfluidic device wraps the chip and all PEGDA-through pipes and syringes with black tape or tinfoil to prevent the device from clogging during UV curing. Connect the syringes fille...

Embodiment 3

[0043] Example 3 Preparation of ethoxylated trimethylolpropane triacrylate (ETPTA) microcapsules carrying colloidal crystals with three different reflection peaks:

[0044] 1. Generation of ETPTA double emulsion: as figure 1 As shown, the injection tube is a capillary tube with seven holes, and the injection tube is hydrophobically treated with a 2 vol.%-10 vol.% acetone solution of octadecyltrimethoxysilane. Assemble the microfluidic device using glass slides, coverslips, sampling needles, and quick-drying adhesives. The inner core solution (A, B, C) is an aqueous solution of three kinds of silica nanoparticles with different particle sizes (10 vol.%, and contains 2wt% F108 as a surfactant), and the shell solution is a solution containing 1wt% light Initiator (HMPP) in ETPTA solution. The continuous phase is methyl silicone oil KF-96 (0.65CS).

[0045] . The microfluidic device is wrapped with black tape or tinfoil to wrap the chip and all the pipes and syringes through ...

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Abstract

The invention discloses a wettability-guided preparation method of microcapsules and application of the microcapsules. The wettability-guided preparation method is characterized in that the microcapsules are obtained by controlling the wettability of a microfluidic channel through a one-step method. The microfluidic channel part is formed by coaxially arranging and assembling one porous capillary tube and one single-hole round tube in one square tube, i.e., a tip of the porous capillary tube is inserted into the single-hole round tube, and meanwhile, central axes of the two tubes are mutually superposed. Oil-soluble microcapsules can be prepared by hydrophobic modification of the porous capillary tube; water-soluble microcapsules can be prepared by hydrophilic modification of the porous capillary tube. The obtained microcapsules have a core-shell structure; in addition, a core of each microcapsule can simultaneously contain different components. The microcapsules can be applied to the technical fields of cell culture, drug encapsulation and the like.

Description

[0001] The invention belongs to the field of biomaterials, and in particular relates to a method for preparing an infiltration-guided microcapsule, which can be applied in technical fields such as cell culture and drug loading. Background technique [0002] Multiple emulsions are nested systems of emulsions. Due to its excellent characteristics of being able to contain and protect some active substances, it has been widely used in many fields such as cell culture, drug delivery, food additives, cosmetics, chemical separation, and controllable micro-reactions. Multiple emulsions are usually prepared by sequential shear-induced emulsification. For example, in order to prepare a double emulsion, the primary structure single emulsion droplets are first prepared, and then the whole emulsion containing small-sized droplets is used as the dispersed phase for the second emulsification to prepare a double emulsion. The double emulsion droplets prepared by this method usually have high...

Claims

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Application Information

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IPC IPC(8): B01J13/02C12N11/08C12N11/10A61K9/50A61K47/14A61K47/34A61K47/36A61K47/32
CPCA61K9/5015A61K9/5026A61K9/5031A61K9/5036A61K9/5089B01J13/025C12N11/08C12N11/10
Inventor 赵远锦商珞然刘玮程瑶顾忠泽
Owner SOUTHEAST UNIV
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