L-palmitoyl ascorbate/paclitaxel composition lipidosome

A technology of ascorbate and ascorbyl palmitate, which is applied in the field of liposome preparation of compound palmitoyl ascorbate and paclitaxel, can solve difficult drug encapsulation, large liposome particle size, inability to achieve sustained release, targeted Dosing and other issues
CN106166146AInactive Publication Date: 2016-11-30陈西敬
2 Cites 0 Cited by

Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
陈西敬
Publication Date
2016-11-30
Estimated Expiration
Not applicable · inactive patent

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

The invention discloses a composition lipidosome preparation used for parenteral administration tumor treatment. The composition lipidosome preparation comprises following ingredients: paclitaxel, L-palmitoyl ascorbate, a phospholipid substance, and a cholesterol analogue. According to a preparation method, L-palmitoyl ascorbate and paclitaxel are combined, the particle size of the obtained lipidosome is uniform, encapsulation efficiency is high, and drug releasing properties are excellent. It is found via in vivo and in vitro experiments that anti-tumor effect of paclitaxel is improved obviously; drug effect of paclitaxel can be achieved at a relatively low dosage; drug administration is realized via intravenous administration, artery administration, intramuscular administration, subcutaneous administration, intraperitoneal administration, and the like; and especially, clinical application availability and safety of paclitaxel are improved via interventional administration methods such as intravenous injection or intratumor injection.
Need to check novelty before this filing date? Find Prior Art

Description

technical field

[0001] The invention relates to a composition liposome preparation for injecting drugs for treating tumors, in particular to a method for preparing a composition liposome of compound palmitoyl ascorbate and paclitaxel. Background technique

[0002] Paclitaxel (Paclitaxel, PTX, chemical structure see Figure 8 ) is a diterpenoid compound originally isolated from the bark of the plant Yew brevifolia, and is one of the most effective natural anticancer drugs found so far. Paclitaxel has a significant effect on advanced ovarian cancer, breast cancer, melanoma, lung cancer, head and neck squamous cell carcinoma, cervical cancer, esophageal cancer, lymphoma, and brain tumor, and has a high cure rate for refractory ovarian cancer and metastatic breast cancer. It has good prospects for the treatment of prostate cancer, gastrointestinal cancer, small cell and non-small cell lung cancer. Paclitaxel is a white crystalline powder, and its chemical properties are relativ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More