Method for rapidly detecting drugs in saliva
A saliva and drug technology, applied in the field of drug detection in saliva, can solve the problems of long detection cycle and high detection environment requirements, and achieve the effects of high cost performance, improved detection sensitivity and good reliability.
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Embodiment 1
[0030] Air background detection:
[0031] Send the blank sampling piece without adding any sample into the thermal desorption sample injector of the ion mobility spectrometry detector. The temperature of the thermal desorption sampler was 180°C. The sample gas obtained by thermal analysis is brought into the ionization region of the ion mobility spectrometer by the carrier gas (air, with the analysis temperature of the sampler at 180°C), and the flow rate of the carrier gas is 400 sccm; the sample is ionized into positive and negative ions in the ionization region. The opened ion gate enters the drift zone formed by a uniform electric field, and is separated and detected in the drift zone to obtain the background detection signal of the instrument. figure 2 The ion mobility spectrum of air background detected by positive ion mode ion mobility spectrometry is given. It can be seen from the figure that the positive ion mode reagent ion peak (RIP) appears at about 4.36ms.
Embodiment 2
[0033] Saliva background testing:
[0034] Utilize the method provided by the invention to utilize ion mobility spectrometry to detect the process of blank saliva sample as follows: get saliva sample, add sodium bicarbonate aqueous solution (2*10 -9mol / L) to adjust the pH value at 9, then measure 50 μL of the above-mentioned saliva solution at the sampling place of the sampling piece, and add an equal volume of auxiliary chemical additive ethanol to the saliva sample at the same time, and then send the sampling piece into the ion mobility spectrometry detector for heating Analyze inside the injector. The temperature of the thermal desorption sampler was 180°C. The sample gas obtained by thermal analysis is brought into the ionization region of the ion mobility spectrometer by the carrier gas (air, with the analysis temperature of the sampler at 180°C), and the flow rate of the carrier gas is 400 sccm; the sample is ionized into positive and negative ions in the ionization reg...
Embodiment 3
[0036] Detection of Drugs in Saliva Samples:
[0037] The process of utilizing ion mobility spectrometry to detect ketamine (K powder) in saliva is as follows:
[0038] (1) Drug standard analysis test: ketamine (K powder), opium are dissolved in 95% ethanol solvent respectively, are made into the solution of 100-500ppm respectively; Two kinds of solutions are carried out ion mobility spectrometry analysis and detection respectively, obtain detection signal respectively, Use the obtained detection signal to establish a library of drug standard ion mobility spectrometry detection results; specifically: take 1 μL of the above-mentioned K powder solution and drop it on the corresponding sampling place on the sampling chip of the ion mobility spectrometry detector, and then send the sampling chip into the In the ion mobility spectrometry thermal analysis injector, detection and analysis are performed in the positive ion mode of the ion mobility spectrometer; the above opium solutio...
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