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Method for rapidly detecting drugs in saliva

A saliva and drug technology, applied in the field of drug detection in saliva, can solve the problems of long detection cycle and high detection environment requirements, and achieve the effects of high cost performance, improved detection sensitivity and good reliability.

Active Publication Date: 2016-12-07
DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

These methods have their own limitations, such as relatively high requirements for the detection environment, relatively long detection cycle, etc.

Method used

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  • Method for rapidly detecting drugs in saliva
  • Method for rapidly detecting drugs in saliva
  • Method for rapidly detecting drugs in saliva

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Air background detection:

[0031] Send the blank sampling piece without adding any sample into the thermal desorption sample injector of the ion mobility spectrometry detector. The temperature of the thermal desorption sampler was 180°C. The sample gas obtained by thermal analysis is brought into the ionization region of the ion mobility spectrometer by the carrier gas (air, with the analysis temperature of the sampler at 180°C), and the flow rate of the carrier gas is 400 sccm; the sample is ionized into positive and negative ions in the ionization region. The opened ion gate enters the drift zone formed by a uniform electric field, and is separated and detected in the drift zone to obtain the background detection signal of the instrument. figure 2 The ion mobility spectrum of air background detected by positive ion mode ion mobility spectrometry is given. It can be seen from the figure that the positive ion mode reagent ion peak (RIP) appears at about 4.36ms.

Embodiment 2

[0033] Saliva background testing:

[0034] Utilize the method provided by the invention to utilize ion mobility spectrometry to detect the process of blank saliva sample as follows: get saliva sample, add sodium bicarbonate aqueous solution (2*10 -9mol / L) to adjust the pH value at 9, then measure 50 μL of the above-mentioned saliva solution at the sampling place of the sampling piece, and add an equal volume of auxiliary chemical additive ethanol to the saliva sample at the same time, and then send the sampling piece into the ion mobility spectrometry detector for heating Analyze inside the injector. The temperature of the thermal desorption sampler was 180°C. The sample gas obtained by thermal analysis is brought into the ionization region of the ion mobility spectrometer by the carrier gas (air, with the analysis temperature of the sampler at 180°C), and the flow rate of the carrier gas is 400 sccm; the sample is ionized into positive and negative ions in the ionization reg...

Embodiment 3

[0036] Detection of Drugs in Saliva Samples:

[0037] The process of utilizing ion mobility spectrometry to detect ketamine (K powder) in saliva is as follows:

[0038] (1) Drug standard analysis test: ketamine (K powder), opium are dissolved in 95% ethanol solvent respectively, are made into the solution of 100-500ppm respectively; Two kinds of solutions are carried out ion mobility spectrometry analysis and detection respectively, obtain detection signal respectively, Use the obtained detection signal to establish a library of drug standard ion mobility spectrometry detection results; specifically: take 1 μL of the above-mentioned K powder solution and drop it on the corresponding sampling place on the sampling chip of the ion mobility spectrometry detector, and then send the sampling chip into the In the ion mobility spectrometry thermal analysis injector, detection and analysis are performed in the positive ion mode of the ion mobility spectrometer; the above opium solutio...

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Abstract

The invention discloses a method for rapidly detecting drugs in saliva. The method comprises the steps of fetching a saliva sample, adding an alkali solution into the saliva sample so as to adjust the pH value of the saliva sample, then, measuring the saliva liquor at a sampling site of a sample introduction sheet, then, adding a certain volume of auxiliary chemical additive into the saliva sample, and feeding the sample introduction sheet to a pyrolysis sample introduction device of an ion mobility spectrometry detector. Analysis and detection are carried out after pyrolysis, and analysis and detection results are output. The measuring detection limit can reach the magnitude not larger than 1ng (concentration not larger than 0.1ppm). The analysis time for an individual sample is shorter than 5S, and software automatically outputs the detection result. According to the method, the measuring method is simple, convenient, rapid and efficient and is good in reliability. In view of oral drug taking and drug abusing cases, the ion mobility spectrometry detector can be used for completely achieving rapid examination through detecting drug ingredients in the saliva by using the method disclosed by the invention. On the basis of applied research requirements in the aspect of forensic sciences, software control instruments can implement an alarm mode according to drug mobility time.

Description

technical field [0001] The invention discloses a fast and sensitive method for detecting narcotics in saliva. The ion mobility spectrometry is used as a basic detection technology, and a positive and negative ion mode is adopted to establish a qualitative method for rapid detection of narcotics in saliva by ion mobility spectrometry. In recent years, drugs have become more and more harmful to human life, and have seriously threatened the normal life of human beings. Therefore, the detection of drugs is very important, especially the confirmation of the criminal facts of drug users. The measuring method is simple, fast, efficient and reliable. For oral drug and drug abuse cases, ion mobility spectrometry can realize rapid screening by detecting drug components in saliva. Background technique [0002] Saliva is a colorless and thin liquid, commonly known as saliva. Although it was called "Jinjinyuye" in ancient times, it has always given people a sense of uncleanness in mode...

Claims

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Application Information

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IPC IPC(8): G01N27/62
Inventor 王新李京华王爱博李海洋
Owner DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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