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Cosmetic cream containing ceramide 2 and sub-micron carnosine lipid particles and preparation method of cosmetic cream

A ceramide, submicron technology, applied in cosmetic preparations, cosmetics, medical preparations containing active ingredients, etc., can solve the problems of limitation and poor skin penetration ability, and achieve improved anti-aging, good biocompatibility, improved The effect of wrinkle volume and depth

Inactive Publication Date: 2017-01-04
OSMUN BIOLOGICAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, as a water-soluble dipeptide, its skin penetration ability is poor, so its application in anti-aging cosmetics is limited

Method used

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  • Cosmetic cream containing ceramide 2 and sub-micron carnosine lipid particles and preparation method of cosmetic cream
  • Cosmetic cream containing ceramide 2 and sub-micron carnosine lipid particles and preparation method of cosmetic cream

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Weigh 5g caprylic / capric triglyceride, 18g octyldodecanol, 2g glyceryl stearate, 2g olive oil PEG-7 esters, 5g polysorbate-60, 3g sorbitan laurate, 15g PEG-30 dipolyhydroxystearate and 5g butanediol were stirred at 65°C and 200 rpm to form a homogeneous solution; then 2g of ceramide 2 was added, and the stirring was continued for about 10 min, then an aqueous solution dissolved in 2g of carnosine was added, Stir at 250 rpm for 8 min, add 0.5 g of phenoxyethanol after proper cooling, continue stirring for 5 min, and cool to obtain solid colloidal ceramide 2 & carnosine submicron lipid particles. The particle size is about 103 nm as measured by a laser particle size analyzer.

Embodiment 2

[0046] Weigh 5g glyceryl stearate, 5g butyl octanyl salicylate, 22g octyldodecanol, 5g ceteth-25, 5g sorbitan olive oil ester, 5g polysorbate-80 , 10g PEG-30 dipolyhydroxystearate, 4g dipropylene glycol and 2g polyglyceryl-3 diisostearate were stirred into a homogeneous solution at 70°C, 1.5g ceramide 2 was added, and the stirring speed was 300 rpm, stirring time is 8 min; add pre-dissolved 3g carnosine and 32g water, stir at 200 rpm for 10 min, add 0.5g phenoxyethanol and ethylhexylglycerin mixture after proper cooling. Cool naturally to obtain off-white ceramide 2 & carnosine submicron liposome solids. The particle size is about 125 nm as measured by a laser particle size analyzer.

Embodiment 3

[0048]Weigh 3g Caprylic / Capric Triglyceride, 2g Glyceryl Monostearate, 2g Butyl Octyl Salicylate, 23g Octyldodecanol, 8g Steareth-21, 5g PEG-30 Dipolyhydroxystearate, 2g Coco Glucoside / Coco Alcohol, 7g Behenyl Alcohol / Polyglyceryl-10 Pentastearate / Sodium Stearoyl Lactyl Lactate Blend, 3g Butylene Glycol, 3g Polysorbate Alcohol ester-80 and 2g sorbitan oleate were stirred at 80 ℃ to form a uniform mixed solution, 2g of ceramide 2 was added, the stirring speed was 300 rpm, and the stirring time was 5 min; then 34g of completely pre-dissolved deionized Water, 3g carnosine and 0.5g methylparaben were stirred at 200 rpm for 8 min, after proper cooling, 0.5g phenoxyethanol was added, and naturally cooled to obtain ceramide 2 & carnosine submicron lipid particles. The particle size of the ceramide 2 & carnosine submicron lipid particle solid is about 89 nm as measured by a laser particle size analyzer.

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Abstract

The invention relates to the technical field of carrier systems in cosmetic preparation technologies, in particular to cosmetic cream containing ceramide 2 and sub-micron carnosine lipid particles and a preparation method of the cosmetic cream. The cosmetic cream containing the ceramide 2 and sub-micron carnosine lipid particles contains the ceramide 2 and sub-micron carnosine lipid particles, and the ceramide 2 and sub-micron carnosine lipid particles are prepared from active ingredients including ceramide 2 and carnosine, lipids, an emulsifier, a co-emulsifier, a stabilizing agent, a preservative and water and are light yellow and semi-transparent in appearance. The cosmetic cream containing the ceramide 2 and sub-micron carnosine lipid particles has the obvious anti-oxidation effect on the skin and has the anti-aging effects of significantly reducing the volume and depth of wrinkles and improving the skin surface texture.

Description

technical field [0001] The present invention relates to the technical field of the carrier system in cosmetics preparation technology, more specifically to a kind of cosmetic cream containing ceramide 2 & carnosine submicron lipid particles and its preparation method. Background technique [0002] Ceramides, also known as sphingolipids, are a class of active ingredients composed of sphingosine long-chain bases and a fatty acid, and play an important role in the fields of skin care and hair care. Studies have shown that ceramides act as a strong barrier on the skin surface, preventing moisture loss and external stimulation, moisturizing and moisturizing the skin. When the skin is dry, desquamated, and cracked, and its barrier function is significantly reduced, supplementing the skin with ceramide can quickly restore moisturizing and barrier function. Different sphingosine bases and fatty acids can be combined to form different ceramides. As one of them, in addition to helpi...

Claims

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Application Information

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IPC IPC(8): A61K8/68A61K8/64A61K8/02A61Q19/08
CPCA61K8/68A61K8/0241A61K8/64A61K2800/41A61Q19/08
Inventor 邓学阳马萍霍刚周示玉
Owner OSMUN BIOLOGICAL
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