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Gastric-juice-soluble capsule shell and preparation method thereof

A capsule shell and stomach-dissolving technology, which is applied in the field of stomach-soluble capsule shell and its preparation, can solve the problems of being easily degraded by enzymes, and achieve the effects of easy purification, easy-to-obtain raw materials, and good cell compatibility

Inactive Publication Date: 2017-01-04
NANTONG TEXTILE & SILK IND TECH RES INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0009] Sericin contains amino acids with strong polar side groups such as hydroxyl, carboxyl and amino groups, accounting for about 70% of the total. Therefore, sericin is a water-soluble globular protein with a structure similar to gelatin, and has good film-forming properties. Gellable, but easily degraded by enzymes

Method used

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  • Gastric-juice-soluble capsule shell and preparation method thereof

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preparation example Construction

[0027] A method for preparing a stomach-soluble capsule shell, comprising the following steps: Step 1: preparing a sericin solution; Step 2: preparing a silk fibroin solution; Step 3: preparing an aqueous solution of proline and ethylene glycol; Step 4: preparing a mixed Solution; step five: preparing finished product;

[0028] in:

[0029] Step 1: Using silkworm cocoon shells or silkworm raw silk as raw materials, add deionized water to boil the cocoons in a boiling water bath, centrifuge and take the supernatant to obtain a sericin solution, measure its mass percentage concentration, and refrigerate in the refrigerator for later use;

[0030] Step 2: Use silkworm cocoon shells or silkworm raw silk as raw materials, degumming to remove sericin, drying, dissolving with lithium bromide, dialyzing in deionized water for 2 to 5 days at 4°C to obtain a silk fibroin solution, and measuring its mass percentage Concentration, refrigerated in the refrigerator for later use;

[0031]...

Embodiment 1

[0038] Step 1, boil the cleaned silkworm cocoons and deionized water in a ratio of 1:10 in a high temperature and high pressure sterilizing pot for 20 minutes, filter the cocoon shells to obtain a sericin solution;

[0039] Step 2: Degumming silkworm cocoons with sodium bicarbonate-sodium carbonate buffered aqueous solution, washing and drying the silkworm cocoons to obtain degummed silk. According to the degummed silk: lithium bromide solution (9.3mol / L) = 1:20 to dissolve the degummed silk, the mixed solution is dialyzed with deionized water at 4°C for 3~4 days to obtain the silk fibroin solution;

[0040] Step 3: Take ethylene glycol and proline, and configure it into an aqueous solution of proline and ethylene glycol for subsequent use;

[0041] Step 4: Mix the solutions of silk fibroin, sericin, ethylene glycol and proline into the mold according to the mass ratio of 2:88:8:2;

[0042] Step 5: Put the mixed solution in an oven at 75°C for 1 hour, and then place it in a c...

Embodiment 2

[0045] Step 1, steaming the cleaned silkworm cocoon and deionized water in a high temperature and high pressure sterilizing pot for 1 hour at a ratio of 1:20, filtering the cocoon shell to obtain a sericin solution;

[0046] Step 2: Degumming silkworm cocoons with sodium bicarbonate-sodium carbonate buffered aqueous solution, washing and drying the silkworm cocoons to obtain degummed silk. According to the degummed silk: lithium bromide solution (9.3mol / L) = 1:10 to dissolve the degummed silk, the mixed solution is dialyzed with deionized water at 4°C for 3~4 days to obtain the silk fibroin solution;

[0047]Step 3: Take ethylene glycol and proline, and configure it into an aqueous solution of proline and ethylene glycol for subsequent use;

[0048] Step 4: Mix the solutions of silk fibroin, sericin, ethylene glycol and proline into the mold according to the mass ratio of 13:77:9:1;

[0049] Step 5: Put the mixed solution in an oven at 75°C for 2 hours, and then put it into a...

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Abstract

The invention relates to a gastric-juice-soluble capsule shell and a preparation method thereof. The gastric-juice-soluble capsule shell is prepared from, by mass, 60-80% of sericin, 0-15% of silk fibroin, 0-25% of ethanediol and 0-25% of proline. Natural fibroin with good biocompatibility serves as the raw material, micromolecules are added to improve the crystallization property of the material, and the material can be used for replacing gelatin to serve as a capsule shell material to solve many problems existing in the method of preparing a capsule shell from gelatin. Cell proliferation experiments prove that the obtained gastric-juice-soluble capsule shell material can support good growth of cells, has good compatibility with cells and is harmless to the human body. Fibroin is cheap and easy to purify, does not carry common pathogens of mammals and is suitable for pharmaceutical adjuvants, and the raw material is easy to obtain.

Description

technical field [0001] The invention relates to the field of pharmaceutical excipients, in particular to a stomach-soluble capsule shell and a preparation method thereof. Background technique [0002] Capsule, as a drug coating material, can not only cover up the smell of the drug, but also improve the stability of the drug, and has a certain degree of purpose protection for the drug. According to the target site loaded with drug therapy, the capsule shell can vary in the degree of tolerance in various parts of the human body, and the disintegration site and disintegration time are different. [0003] The material widely used in the production of hollow hard capsules is gelatin. Gelatin is obtained by boiling the bones and skins of cattle, sheep, pigs, etc. As the main raw material of capsules, gelatin has many unique properties, such as gelling, film-forming, emulsifying, and cohesive properties of gelatin. These properties are the advantages of gelatin as a capsule mate...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/48A61K47/42
CPCA61K9/4825
Inventor 卢神州吴峰陈大旗付华卢欣暘
Owner NANTONG TEXTILE & SILK IND TECH RES INST
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