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Oral care composition

An oral care and composition technology, applied in the field of oral care, can solve problems such as retention, toxic and side effects, and achieve the effects of improving stability and accelerating proliferation

Inactive Publication Date: 2017-01-04
LAFANG CHINA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the study of liposome transdermal administration shows that: liposomes with a particle size greater than 1000nm mainly stay in the stratum corneum; liposomes with a particle size of 600nm-1000nm can penetrate into the epidermis and dermis; Liposomes will directly enter the body's circulatory system, causing toxic side effects

Method used

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preparation example Construction

[0025] Preparation method of the best embodiment:

[0026] Add recombinant epidermal cell growth factor, tetrahydropyrimidine, gel (polyethylene glycol 4000, gelatin, sodium carboxymethyl cellulose, carbomer 980) to glycerin at room temperature and stir (after 30 minutes in the carbomer system (Need to add triethanolamine to neutralize) to form a transparent gel, add water and continue to stir for 2 hours and then stand for use.

[0027] The hydrogel, lecithin, cholesterol, ceramide, and sphingomyelin are dissolved in an organic solvent to prepare a lipid solution.

[0028] The liposome solution is directly sprayed and suspended on the proppant in the middle of the fluidized bed through a fluidized bed, and the organic solvent is volatilized to obtain the recombinant epidermal cell growth factor / tetrahydropyrimidine hydrogel liposome.

[0029] The organic solvents described in this embodiment include dichloromethane, chloroform, ether and ethanol.

[0030] The proppant described in thi...

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Abstract

The invention discloses an oral care composition. The oral care composition is composed of multi-phase unilamelar liposome mediated recombination epidermal growth factors and ectoine biosynthesis mixed water gel, wherein the liposome accounts for 80-99.8% the weight of the composition, and the average grain diameter is 600-1600 nanometers; the recombination epidermal growth factors account for 0.1-10.0% the weight of the composition, the concentration is 100-2000 mg / kg, the molecular weight is 5900-6500 Da, the sedimentation coefficient is 1.20-1.30 S, the isoelectric point is pH 4.5-4.9, and the recombination epidermal growth factors are freeze-dried powder. The ectoine biosynthesis mixed water gel accounts for 0.1-10.0% the mass of the composition, the purity is 99-100%, and the ectoine biosynthesis mixed water gel is powdery. The oral care composition has the synergistic interaction effect on prevention and treatment of oral inflammations and anabrosis.

Description

Technical field [0001] The invention relates to the field of oral care, in particular to a mixed hydrogel composition of a multiphase single-compartment liposome encapsulating a recombinant epidermal growth factor and tetrahydropyrimidine. Background technique [0002] Epidermai Growth Factor, abbreviated as EGF; is a biologically active peptide composed of 53 amino acids that is widely present in human skin cells, body fluids, kidneys and brain tissues. It is a biologically functional organism Active substance has a strong biological effect. In the human body, a very small amount of epidermal growth factor can play a great biological role, which can promote the proliferation and growth of skin tissue cells, so that new and young cells can quickly replace aging and dead cells. Supplementing skin cells with epidermal growth factor on a regular basis can continue to promote cell synthesis, maintain the vigorous metabolism of epidermal cells, and promote skin and mucosal wound heal...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/18A61K9/127A61P1/02A61K31/505
CPCA61K9/006A61K9/127A61K31/505A61K38/1808A61K47/24A61K47/38A61K47/42A61K2300/00
Inventor 田俊
Owner LAFANG CHINA CO LTD
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